The Journal of Pediatrics
Volume 154, Issue 6 , Pages 873-876 , June 2009

The Role of Patent Ductus Arteriosus Ligation in Bronchopulmonary Dysplasia: Reexamining a Randomized Controlled Trial

  • Ronald Clyman, MD

      Affiliations

    • Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, CA
    • Corresponding Author InformationReprint requests: Ronald I. Clyman, MD, Box 0544, HSW 1408, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94143-0544
    • ,
  • George Cassady, MD

      Affiliations

    • Department of Pediatrics, University of Alabama at Birmingham School of Medicine, Birmingham, AL
    • ,
  • James K. Kirklin, MD

      Affiliations

    • Department of Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, AL
    • ,
  • Monica Collins, RN, MAED

      Affiliations

    • Department of Pediatrics, University of Alabama at Birmingham School of Medicine, Birmingham, AL
    • ,
  • Joseph B. Philips III, MD

      Affiliations

    • Department of Pediatrics, University of Alabama at Birmingham School of Medicine, Birmingham, AL

Received 8 August 2008 ,Revised 16 December 2008 ,Accepted 6 January 2009.

References 

  1. Gerhardt T, Bancalari E. Lung compliance in newborns with patent ductus arteriosus before and after surgical ligation. Biol Neonate. 1980;38:96–105
  2. Naulty CM, Horn S, Conry J, Avery GB. Improved lung compliance after ligation of patent ductus arteriosus in hyaline membrane disease. J Pediatr. 1978;93:682–684
  3. Stefano JL, Abbasi S, Pearlman SA, Spear ML, Esterly KL, Bhutani VK. Closure of the ductus arteriosus with indomethacin in ventilated neonates with respiratory distress syndrome (Effects of pulmonary compliance and ventilation). Am Rev Respir Dis. 1991;143:236–239
  4. Yeh TF, Thalji A, Luken L, Lilien L, Carr I, Pildes RS. Improved lung compliance following indomethacin therapy in premature infants with persistent ductus arteriosus. Chest. 1981;80:698–700
  5. Szymankiewicz M, Hodgman JE, Siassi B, Gadzinowski J. Mechanics of breathing after surgical ligation of patent ductus arteriosus in newborns with respiratory distress syndrome. Biol Neonate. 2004;85:32–36
  6. Cotton RB, Stahlman MT, Berder HW, Graham TP, Catterton WZ, Kover I. Randomized trial of early closure of symptomatic patent ductus arteriosus in small preterm infants. J Pediatr. 1978;93:647–651
  7. Al Faleh K, Smyth J, Roberts R, Solimano A, Asztalos E, Schmidt B. Prevention and 18-month outcome of serious pulmonary hemorrhage in extremely low birth weight infants: results from the trial of indomethacin prophylaxis in preterms. Pediatrics. 2008;121:e233–e238
  8. Domanico RS, Waldman JD, Lester LA, McPhillips HA, Catrambone JE, Covert RF. Prophylactic indomethacin reduces the incidence of pulmonary hemorrhage and patent ductus arteriosus in surfactant treated infants < 1250 grams. Pediatr Res. 1994;35:331A
  9. Clyman RI, Chorne N. Patent ductus arteriosus: evidence for and against treatment. J Pediatr. 2007;150:216–219
  10. Clyman RI, Chorne N. PDA treatment: effects on pulmonary hemorrhage and pulmonary morbidity. J Pediatr. 2008;152:447–448
  11. McCurnin D, Seidner S, Chang LY, Waleh N, Ikegami M, Petershack J, et al. Ibuprofen-induced ductus arteriosus closure: physiological, histological and biochemical effects on the premature lung. Pediatrics. 2008;121:945–956
  12. Cassady G, Crouse DT, Kirklin JW, Strange MJ, Jonier CH, Godoy G, et al. A randomized, controlled trial of very early prophylactic ligation of the ductus arteriosus in babies who weighed 1000 g or less at birth. N Engl J Med. 1989;320:1511–1516
  13. Kabra NS, Schmidt B, Roberts RS, Doyle LW, Papile L, Fanaroff A. Neurosensory impairment after surgical closure of patent ductus arteriosus in extremely low birth weight infants: results from the Trial of Indomethacin Prophylaxis in Preterms. J Pediatr. 2007;150:229–234
  14. Chorne N, Leonard C, Piecuch R, Clyman RI. Patent ductus arteriosus and its treatment as risk factors for neonatal and neurodevelopmental morbidity. Pediatrics. 2007;119:1165–1174
  15. Chang LY, McCurnin D, Yoder B, Clyman R. Ductus arteriosus ligation and alveolar growth in preterm baboons with a patent ductus arteriosus. Pediatr Res. 2008;63:299–302
  16. Gersony WM, Peckham GJ, Ellison RC, Miettinen OS, Nadas AS. Effects of indomethacin in premature infants with patent ductus arteriosus: results of a national collaborative study. J Pediatr. 1983;102:895–906
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  20. Walsh MC, Szefler S, Davis J, Allen M, Van Marter L, Abman S, et al. Summary proceedings from the bronchopulmonary dysplasia group. Pediatrics. 2006;117:S52–S56
  21. Vick GW, Satterwhite C, Cassady G, Philips J, Yester MV, Logic JR. Radionuclide angiography in the evaluation of ductal shunts in preterm infants. J Pediatr. 1982;101:264–268
  22. Bell MJ, Ternberg JL, Feigin RD, Keating JP, Marshall R, Barton L, et al. Neonatal necrotizing enterocolitis (Therapeutic decisions based upon clinical staging). Ann Surg. 1978;187:1–7
  23. Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weight < 1500 grams. J Pediatr. 1978;92:529–534
  24. Noori S, Friedlich P, Seri I, Wong P. Changes in myocardial function and hemodynamics after ligation of the ductus arteriosus in preterm infants. J Pediatr. 2007;150:597–602
  25. Moin F, Kennedy KA, Moya FR. Risk factors predicting vasopressor use after patent ductus arteriosus ligation. Am J Perinatol. 2003;20:313–320
  26. Clement WA, El-Hakim H, Phillipos EZ, Cote JJ. Unilateral vocal cord paralysis following patent ductus arteriosus ligation in extremely low-birth-weight infants. Arch Otolaryngol Head Neck Surg. 2008;134:28–33

 This study was supported in part by grants from the U.S. Public Health Service, NHLBI (HL46691, HL56061), and a gift from the Jamie and Bobby Gates Foundation. R.C. is the recipient of a research grant from Ovation Pharmaceuticals, Inc. The authors declare no conflicts of interest.

PII: S0022-3476(09)00006-7

doi: 10.1016/j.jpeds.2009.01.005

The Journal of Pediatrics
Volume 154, Issue 6 , Pages 873-876 , June 2009

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