The Journal of Pediatrics
Volume 154, Issue 6 , Pages 877-881.e4 , June 2009

Signs and Symptoms that Precede Wheezing in Children with a Pattern of Moderate-to-Severe Intermittent Wheezing

  • Katherine Rivera-Spoljaric, MD, MSCI

      Affiliations

    • From the Department of Pediatrics, Washington University School of Medicine, St Louis, MO
    • Corresponding Author InformationReprint requests: Katherine Rivera-Spoljaric, MD, MSCI, Washington University School of Medicine, Department of Pediatrics, Campus Box 8116-NWT, St Louis, MO 63110-1077
    • ,
  • Vernon M. Chinchilli, PhD

      Affiliations

    • Department of Public Health Sciences, Penn State College of Medicine, Hershey
    • ,
  • Lindsay J. Camera, BS

      Affiliations

    • Department of Public Health Sciences, Penn State College of Medicine, Hershey
    • ,
  • Robert S. Zeiger, MD, PhD

      Affiliations

    • Department of Pediatrics, Kaiser Permanente, San Diego, CA
    • ,
  • Ian M. Paul, MD, MSc

      Affiliations

    • Department of Pediatrics, Penn State College of Medicine, Hershey
    • ,
  • Brenda R. Phillips, MS

      Affiliations

    • Department of Public Health Sciences, Penn State College of Medicine, Hershey
    • ,
  • Lynn M. Taussig, MD

      Affiliations

    • Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO
    • ,
  • Robert C. Strunk, MD

      Affiliations

    • From the Department of Pediatrics, Washington University School of Medicine, St Louis, MO
    • ,
  • Leonard B. Bacharier, MD

      Affiliations

    • From the Department of Pediatrics, Washington University School of Medicine, St Louis, MO
    • ,
  • Childhood Asthma Research and Education (CARE) Network

Received 8 July 2008 ,Revised 23 September 2008 ,Accepted 10 December 2008.

References 

  1. Bacharier LB, Phillips BR, Bloomberg GR, Zeiger RS, Paul IM, Krawiec M, et al. Severe intermittent wheezing in preschool children: a distinct phenotype. J Allergy Clin Immunol. 2007;119:604–610
  2. Elizur A, Bacharier LB, Strunk RC. Pediatric asthma admissions: chronic severity and acute exacerbations. J Asthma. 2007;44:285–289
  3. National Heart, Lung, and Blood Institute and the National Asthma Education and Prevention Program. Expert Panel Report 3 (EPR 3): Guidelines for the Diagnosis and Management of Asthma, 2007. http://www.nhlbi.nih.gov/guidelines/asthma/asthgdln.htmAccessed 8 July 2008
  4. Cane RS, Ranganathan SC, McKenzie SA. What do parents of wheezy children understand by “wheeze”?. Arch Dis Child. 2000;82:327–332
  5. Cane RS, McKenzie SA. Parents' interpretations of children's respiratory symptoms on video. Arch Dis Child. 2001;84:31–34
  6. Young B, Fitch GE, Dixon-Woods M, Lambert PC, Brooke AM. Parents' accounts of wheeze and asthma related symptoms: a qualitative study. Arch Dis Child. 2002;87:131–134
  7. Yoos HL, Kitzman H, McMullen A, Sidora K. Symptom perception in childhood asthma: how accurate are children and their parents?. J Asthma. 2003;40:27–39
  8. Halterman JS, Yoos HL, Kitzman H, Anson E, Sidora-Arcoleo K, McMullen A. Symptom reporting in childhood asthma: a comparison of assessment methods. Arch Dis Child. 2006;91:766–770
  9. Cunha SS, Newcombe PJ. Parental understanding of wheeze and its impact on asthma prevalence estimates. Eur Respir J. 2007;29:1069–1070
  10. Michel G, Silverman M, Strippoli MP, Zwahlen M, Brooke AM, Grigg J, et al. Parental understanding of wheeze and its impact on asthma prevalence estimates. Eur Respir J. 2006;28:1124–1130
  11. Wilson NM, Silverman M. Treatment of acute, episodic asthma in preschool children using intermittent high-dose inhaled steroids at home. Arch Dis Child. 1990;65:407–410
  12. Connett G, Lenney W. Prevention of viral-induced asthma attacks using inhaled budesonide. Arch Dis Child. 1993;68:85–87
  13. Connett GJ, Warde C, Wooler E, Lenney W. Use of budesonide in severe asthmatics aged 1-3 years. Arch Dis Child. 1993;69:351–355
  14. Garrett J, Williams S, Wong C, Holdaway D. Treatment of acute asthmatic exacerbations with an increased dose of inhaled steroid. Arch Dis Child. 1998;79:12–17
  15. Volovitz B, Bentur L, Finkelstein Y, Mansour Y, Shalitin S, Nussinovitch M, et al. Effectiveness and safety of inhaled corticosteroids in controlling acute asthma attacks in children who were treated in the emergency department: a controlled comparative study with oral prednisolone. J Allergy Clin Immunol. 1998;102:605–609
  16. Svedmyr J, Nyberg E, Thunqvist P, Asbrink-Nilsson E, Hedlin G. Prophylactic intermittent treatment with inhaled corticosteroids of asthma exacerbations due to airway infections in toddlers. Acta Paediatr. 1999;88:42–47
  17. Volovitz B, Nussinovitch M, Finkelstein Y, Harel L, Varsano I. Effectiveness of inhaled corticosteroids in controlling acute asthma exacerbations in children at home. Clin Pediatr. 2001;40:79–86
  18. FitzGerald JM, Becker A, Sears MR, Mink S, Chung K, Lee J. Doubling the dose of budesonide versus maintenance treatment in asthma exacerbations. Thorax. 2004;59:550–556
  19. Harrison TW, Oborne J, Newton S, Tattersfield AE. Doubling the dose of inhaled corticosteroid to prevent asthma exacerbations: randomised controlled trial. Lancet. 2004;24:271–275
  20. Volovitz B. Inhaled budesonide in the management of acute worsenings and exacerbations of asthma: a review of the evidence. Resp Med. 2007;101:685–695

 Supported by grants from the National Heart, Lung, and Blood Institute (5U10HL064287, 5U10HL064288, 5U10HL064295, 5U10HL064307, 5U10HL064305, and 5U10HL064313), General Clinical Research Centers at Washington University School of Medicine (M01 RR00036), and National Jewish Medical and Research Center (M01 RR00051).

 The authors declare no potential conflicts of interest.

PII: S0022-3476(08)01098-6

doi: 10.1016/j.jpeds.2008.12.029

The Journal of Pediatrics
Volume 154, Issue 6 , Pages 877-881.e4 , June 2009

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