The Journal of Pediatrics
Volume 154, Issue 6 , Pages 888-894 , June 2009

Common Variable Immunodeficiency Disorders in Children: Delayed Diagnosis Despite Typical Clinical Presentation

  • Simon Urschel, MD

      Affiliations

    • Pediatric Immunology and Infectious Diseases, University Children's Hospital, Ludwig Maximilians University, Munich, Germany
    • Pediatric Cardiology and Intensive Care, University College Hospital Grosshadern, Munich, Germany
    • Corresponding Author InformationReprint requests: Dr. Simon Urschel, Pediatric Immunology and Infectious Diseases, Dr. von Haunersches Kinderspital, Ludwig Maximilians University, Lindwurmstr. 4, 80337 Munich, Germany
    • ,
  • Lale Kayikci, MD

      Affiliations

    • Pediatric Immunology and Infectious Diseases, University Children's Hospital, Ludwig Maximilians University, Munich, Germany
    • ,
  • Uwe Wintergerst, MD

      Affiliations

    • Pediatric Immunology and Infectious Diseases, University Children's Hospital, Ludwig Maximilians University, Munich, Germany
    • ,
  • Gundula Notheis, MD

      Affiliations

    • Pediatric Immunology and Infectious Diseases, University Children's Hospital, Ludwig Maximilians University, Munich, Germany
    • ,
  • Annette Jansson, MD

      Affiliations

    • Pediatric Immunology and Infectious Diseases, University Children's Hospital, Ludwig Maximilians University, Munich, Germany
    • ,
  • Bernd H. Belohradsky, MD

      Affiliations

    • Pediatric Immunology and Infectious Diseases, University Children's Hospital, Ludwig Maximilians University, Munich, Germany

Received 29 April 2008 ,Revised 8 October 2008 ,Accepted 5 December 2008.

  • Image Result

    IgG (circles), IgM (triangles), and IgA (diamonds) serum level in each patient at first diagnosis. The line in upper chart shows age-related third percentile of normal IgG values, in the lower chart n

    IgG (circles), IgM (triangles), and IgA (diamonds) serum level in each patient at first diagnosis. The line in upper chart shows age-related third percentile of normal IgG values, in the lower chart normal values for IgM (light line) and IgA (dark line) for each age as published by Uffelmann et al13 with adult values for children aged more than 14 years.

  • Image Result
    Lymphocyte subset distribution in pediatric CVID-patients at first diagnosis: Normal percentage for CD4+ T-cells (41.2 ± 10.9), CD8+ T-cells (26.5 ± 8.5), natural killer cells (7.5 ± 3.6). B-cells wit

    Lymphocyte subset distribution in pediatric CVID-patients at first diagnosis: Normal percentage for CD4+ T-cells (41.2 ± 10.9), CD8+ T-cells (26.5 ± 8.5), natural killer cells (7.5 ± 3.6). B-cells within lower normal range (9.7 ± 6.6). Boxes represent 25th, 50th and 75th percentile, range bars show 10th and 90th percentile, and black circles represent 5th and 95th percentile. Dotted line represents the geometric mean.

 There are no funding or financial affiliations influencing the content of the manuscript or leading to a conflict of interest.

PII: S0022-3476(08)01080-9

doi: 10.1016/j.jpeds.2008.12.020

The Journal of Pediatrics
Volume 154, Issue 6 , Pages 888-894 , June 2009

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