The Journal of Pediatrics
Volume 154, Issue 5 , Pages 688-693, May 2009

Methotrexate in Pediatric Osteosarcoma: Response and Toxicity in Relation to Genetic Polymorphisms and Dihydrofolate Reductase and Reduced Folate Carrier 1 Expression

  • Ana Patiño-García, PhD

      Affiliations

    • Laboratory of Pediatrics, University of Navarra/University Clinic, Pamplona, Spain
    • Corresponding Author InformationReprint requests: Ana Patiño-García, PhD, Laboratory of Pediatrics, University of Navarra/University Clinic, Irunlarrea SN, Los Castaños Building, 31080 Pamplona, Spain
    • ,
  • Marta Zalacaín, PhD

      Affiliations

    • Laboratory of Pediatrics, University of Navarra/University Clinic, Pamplona, Spain
    • ,
  • Lucía Marrodán, BSc

      Affiliations

    • Laboratory of Pediatrics, University of Navarra/University Clinic, Pamplona, Spain
    • ,
  • Mikel San-Julián, MD, PhD

      Affiliations

    • Department of Traumatology and Orthopaedic Surgery, University Clinic of Navarra, Pamplona, Spain
    • ,
  • Luis Sierrasesúmaga, MD, PhD

      Affiliations

    • Laboratory of Pediatrics, University of Navarra/University Clinic, Pamplona, Spain

Received 29 April 2008; received in revised form 17 September 2008; accepted 17 November 2008. published online 22 January 2009.

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 This work was partially supported by a grant from the Department of Education and Culture of the Gobierno de Navarra. The authors declare no conflicts of interest.

PII: S0022-3476(08)01041-X

doi:10.1016/j.jpeds.2008.11.030

The Journal of Pediatrics
Volume 154, Issue 5 , Pages 688-693, May 2009

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