The Journal of Pediatrics
Volume 154, Issue 5 , Pages 766-768, May 2009

Homozygous α-Thalassemia Treated with Intrauterine Transfusions and Unrelated Donor Hematopoietic Cell Transplantation

  • Joanna S. Yi, MD

      Affiliations

    • Department of Pediatrics, University of Minnesota, Minneapolis, MN
    • ,
  • Christopher L. Moertel, MD

      Affiliations

    • Division of Pediatric Hematology/Oncology Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN
    • Corresponding Author InformationReprint requests: Christopher L. Moertel, MD, Mayo Mail Code 484/420 Delaware St SE, Minneapolis, MN 55455
    • ,
  • K. Scott Baker, MD

      Affiliations

    • Division of Pediatric Hematology/Oncology Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN

Received 12 June 2008; received in revised form 3 October 2008; accepted 17 November 2008.

Recently, intrauterine transfusions and hematopoietic cell transplantation (HCT) have changed homozygous alpha-thalassemia from a frequently fatal disease to a potentially survivable condition. We present a patient with Hemoglobin Bart's disease who was cured after failing to engraft with 1 unrelated HCT, but engrafting after a second unrelated donor HCT.

Abbreviations: ATG, Anti-thymocyte globulin, BMT, Bone marrow transplant, GVHD, Graft versus host disease, Hb, Hemoglobin, HCT, Hematopoietic cell transplantation, HLA, Human leukocyte antigen, TBI, Total body irradiation, TLI, Total lymphoid irradiation

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 The authors declare no conflicts of interest.

PII: S0022-3476(08)01040-8

doi:10.1016/j.jpeds.2008.11.031

The Journal of Pediatrics
Volume 154, Issue 5 , Pages 766-768, May 2009

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