The Journal of Pediatrics
Volume 154, Issue 5 , Pages 754-758 , May 2009

Immunopathology of Chronic Rhinosinusitis in Young Children

  • Laurent Coffinet, MD

      Affiliations

    • Service ORL, Hopital Central, Nancy, France
    • ,
  • Kenny H. Chan, MD

      Affiliations

    • Department of Otolaryngology–Head and Neck Surgery, University of Colorado at Denver School of Medicine, The Children's Hospital, Denver, CO
    • Corresponding Author InformationReprint requests: Kenny H. Chan, MD, Department of Pediatric Otolaryngology, The Children's Hospital, 13123 East 16th Ave, B455, Aurora, CO 80045
    • ,
  • Mark J. Abzug, MD

      Affiliations

    • Department of Pediatrics (Section of Infectious Diseases), University of Colorado at Denver School of Medicine, The Children's Hospital, Denver, CO
    • ,
  • Eric A.F. Simões, MB, BS, DCH, MD

      Affiliations

    • Department of Pediatrics (Section of Infectious Diseases), University of Colorado at Denver School of Medicine, The Children's Hospital, Denver, CO
    • ,
  • Carlyne Cool, MD

      Affiliations

    • Department of Pathology, University of Colorado at Denver School of Medicine, The Children's Hospital, Denver, CO
    • ,
  • Andrew H. Liu, MD

      Affiliations

    • Department of Pediatrics (Section of Allergy/Immunology), University of Colorado at Denver School of Medicine, The Children's Hospital, Denver, CO
    • National Jewish Health, Denver, CO

Received 18 July 2008 ,Revised 29 September 2008 ,Accepted 17 November 2008.

References 

  1. Baroody FM, Hughes CA, McDowell P, Hruban R, Zinreich SJ, Naclerio RM. Eosinophilia in chronic childhood sinusitis. Arch Otolaryngol. 1995;121:1396–1402
  2. Hamilos DL, Leung DY, Wood R, Meyers A, Stephens JK, Barkans J, et al. Chronic hyperplastic sinusitis: association of tissue eosinophilia with mRNA expression of granulocyte-macrophage colony-stimulating factor and interleukin-3. J Allergy Clin Immunol. 1993;92:29–48
  3. Hamilos DL, Leung DY, Wood R, Cunningham L, Bean DK, Yasruel Z, et al. Evidence for distinct cytokine expression in allergic versus nonallergic chronic sinusitis. J Allergy Clin Immunol. 1995;96:537–544
  4. Harlin SL, Ansel DG, Lane SR, Myers J, Kephart GM, Gleich GJ. A clinical and pathologic study of chronic sinusitis: the role of the eosinophil. J Allergy Clin Immunol. 1988;81:867–875
  5. Chan KH, Abzug MJ, Coffinet L, Simoes EAF, Cool C, Liu AH. Chronic rhinosinusitis in young children differs from adults: a histopathology study. J Pediatr. 2004;144:206–212
  6. Driscoll PV, Naclerio RM, Baroody FM. CD4+ lymphocytes are increased in the sinus mucosa of children with chronic sinusitis. Arch Otolaryngol. 1996;122:1071–1076
  7. Busse WW, Lemanske RF. Asthma. N Engl J Med. 2001;344:350–362
  8. Hamid QA, Minshall EM. Molecular pathology of allergic disease: I: lower airway disease. J Allergy Clin Immunol. 2000;105:20–36
  9. Marguet C, Jouen-Boedes F, Dean TP, Warner JO. Bronchoalveolar cell profiles in children with asthma, infantile wheeze, chronic cough, or cystic fibrosis. Am J Respir Crit Care Med. 1999;159:1533–1540
  10. Krawiec ME, Westcott JY, Chu HW, Balzar S, Trudeau JB, Schwartz LB, et al. Persistent wheezing in very young children is associated with lower respiratory inflammation. Am J Respir Crit Care Med. 2001;163:1338–1343
  11. Le Bourgeois M, Goncalves M, Le Clainche L, Benoist MR, Fournet JC, Scheinmann P, et al. Bronchoalveolar cells in children <3 years old with severe recurrent wheezing. Chest. 2002;122:791–797
  12. Saglani S, Malmström K, Pelkonen AS, Malmberg LP, Lindahl H, Kajosaari M, et al. Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction. Am J Respir Crit Care Med. 2005;171:722–727

 This research was supported in part by grants from the General Clinical Research Centers Program (#MO1 RR00069), National Center for Research Resources, National Institutes of Health (Dr Chan); The Research Institute, The Children's Hospital, Denver, Colorado (Dr Chan); and National Institutes of Health (#K23-HL-04272; Dr Liu). The authors declare no conflict of interest, real or perceived.

PII: S0022-3476(08)01035-4

doi: 10.1016/j.jpeds.2008.11.035

The Journal of Pediatrics
Volume 154, Issue 5 , Pages 754-758 , May 2009

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