Fetal and Neonatal Habituation in Infants of Diabetic Mothers

Gonzalez-Gonzalez, N.L.; Medina, V.; Padron, E.; Domenech, E.; Diaz Gomez, N.M.; Armas, H.; Bartha, J.L.

doi:10.1016/j.jpeds.2008.10.020

« Previous Next »The Journal of Pediatrics
Volume 154, Issue 4 , Pages 492-497, April 2009

Fetal and Neonatal Habituation in Infants of Diabetic Mothers

N.L. Gonzalez-Gonzalez, PhD
- Department of Obstetrics and Gynecology, University Hospital of the Canary Islands, Canary Islands, Spain
- Reprint requests: Prof. Nieves Luisa González González, Avda de la Universidad no. 27. La Laguna, 38208. Tenerife, Canary Islands, Spain
V. Medina, PhD
- Department of Obstetrics and Gynecology, University Hospital of the Canary Islands, Canary Islands, Spain
E. Padron, PhD
- Department of Obstetrics and Gynecology, University Hospital of the Canary Islands, Canary Islands, Spain
E. Domenech, PhD
- Department of Paediatrics, University Hospital of the Canary Islands, Canary Islands, Spain
N.M. Diaz Gomez, PhD
- Nursing School, University of La Laguna, Tenerife, Canary Islands, Spain
H. Armas, PhD
- Department of Paediatrics, University Hospital of the Canary Islands, Canary Islands, Spain
J.L. Bartha, PhD
- Department of Obstetrics and Gynaecology, University Hospital “Puerta del Mar” Cádiz, Spain

Received 2 March 2008; received in revised form 10 September 2008; accepted 13 October 2008. published online 04 December 2008.

Objective

To evaluate whether maternal diabetes alters the habituation ability of fetuses and newborns.

Study design

Two nonrandomized clinical trials were performed. First, we studied prenatal fetuses of women with pregestational diabetes, and control subjects matched for gestational age, and then we studied infants of diabetic mothers (IDM) and control subjects matched for gestational age and mode of delivery. Fetus and newborns were stimulated with vibroacoustic stimulus.

Results

In fetuses of diabetic mothers, the ability to habituate was lower, and the habituation rate was higher than in control subjects to all habituation tests. In the neonatal period, ability to habituate was lower (59% vs 100%; P < .001), and the habituation rate was higher (18 [14-21] vs 4 [1.2-6.8]; P < .001) in the IDM than in the control infants. We found a significant negative correlation between maternal glycosylated hemoglobin in each trimester of pregnancy and habituation ability in IDM.