The Journal of Pediatrics
Volume 154, Issue 4 , Pages 592-595.e2 , April 2009

Associated Symptoms in the Ten Days Before Diagnosis of Kawasaki Disease

  • Annette L. Baker, MSN, PNP

      Affiliations

    • Children's Hospital Boston and Harvard Medical School, Boston, MA
    • Corresponding Author InformationReprint requests: Annette L. Baker, MSN, PNP, Department of Cardiology, Children's Hospital Boston, 300 Longwood Ave, Boston, MA 02115
    • ,
  • Minmin Lu, MS

      Affiliations

    • New England Research Institutes, Watertown, MA
    • ,
  • L. LuAnn Minich, MD

      Affiliations

    • Primary Children's Medical Center, Salt Lake City, UT
    • ,
  • Andrew M. Atz, MD

      Affiliations

    • Medical University of South Carolina, Charleston, SC
    • ,
  • Gloria L. Klein, MS, RD

      Affiliations

    • New England Research Institutes, Watertown, MA
    • ,
  • Rosalind Korsin, RN

      Affiliations

    • Columbia University Medical Center, New York, NY
    • ,
  • Linda Lambert, MSN

      Affiliations

    • Primary Children's Medical Center, Salt Lake City, UT
    • ,
  • Jennifer S. Li, MD

      Affiliations

    • Duke University Medical Center, Durham, NC
    • ,
  • Wilbert Mason, MD

      Affiliations

    • Children's Hospital of Los Angeles and University of Southern California, Los Angeles, CA
    • ,
  • Elizabeth Radojewski, RN

      Affiliations

    • University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    • ,
  • Victoria L. Vetter, MD

      Affiliations

    • The Children's Hospital of Philadelphia, Philadelphia, PA
    • ,
  • Jane W. Newburger, MD, MPH

      Affiliations

    • Children's Hospital Boston and Harvard Medical School, Boston, MA
    • ,
  • Pediatric Heart Network Investigators

Received 27 May 2008 ,Revised 4 September 2008 ,Accepted 3 October 2008.

References 

  1. Newburger JW, Takahashi M, Gerber MA, Gewitz MH, Tani LY, Burns JC, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Circulation. 2004;110:2747–2771
  2. Kawasaki T. [Acute febrile mucocutaneous lymph node syndrome: clinical observations of 50 cases]. Arerugi. 1967;16:178–222Japanese
  3. Taubert KA, Rowley AH, Shulman ST. Nationwide survey of Kawasaki disease and acute rheumatic fever. J Pediatr. 1991;119:279–282
  4. Kato H, Sugimura T, Akagi T, Sato N, Hashino K, Maeno Y, et al. Long-term consequences of Kawasaki disease: a 10- to 21-year follow-up study of 594 patients. Circulation. 1996;94:1379–1385
  5. Newburger JW, Takahashi M, Burns JC, Beiser AS, Duffy CE, Glode MP, et al. The treatment of Kawasaki syndrome with intravenous gamma globulin. N Engl J Med. 1986;315:341–347
  6. Terai M, Shulman ST. Prevalence of coronary artery abnormalities in Kawasaki disease is highly dependent on gamma globulin dose but independent of salicylate dose. J Pediatr. 1997;131:888–893
  7. Kim T, Choi W, Woo CW, Choi B, Lee J, Lee K, et al. Predictive risk factors for coronary artery abnormalities in Kawasaki disease. Eur J Pediatr. 2007;166:421–425
  8. Minich LL, Sleeper LA, Atz AM, McCrindle BW, Lu M, Colan SD, et al. Delayed diagnosis of Kawasaki disease: what are the risk factors?. Pediatr. 2007;120:e1434–e1440
  9. Newburger JW, Sleeper LA, McCrindle BW, Minich LL, Gersony W, Vetter VL, et al. Randomized trial of pulsed corticosteroid therapy for primary treatment of Kawasaki disease. N Engl J Med. 2007;356:663–675
  10. Research Committee on Kawasaki Disease. Report of subcommittee on standardization of diagnostic criteria and reporting of coronary artery lesions in Kawasaki disease. Tokyo: Ministry of Health and Welfare; 1984;
  11. Benseler SM, McCrindle BW, Silverman ED, Tyrrell PN, Wong J, Yeung RS. Infections and Kawasaki disease: implications for coronary artery outcome. Pediatr. 2005;116:e760–e766
  12. Burns JC, Mason WH, Glode MP, Shulman ST, Melish ME, Meissner C, et al. Clinical and epidemiologic characteristics of patients referred for evaluation of possible Kawasaki disease. J Pediatr. 1991;118:680–686
  13. Hicks RV, Melish ME. Kawasaki syndrome. Pediatr Clin North Am. 1986;33:1151–1175
  14. Melish ME, Hicks RV. Kawasaki syndrome: clinical features (Pathophysiology, etiology and therapy). J Rheumatol Suppl. 1990;24:2–10

 Supported by National Institutes of Health grants U01 HL068285 and RR 02172 (J.N., A.B., R.P.Sundel); U01 HL068270 (M.L., G.K.), U01 HL068292 (L.M., L.L.), U01 HL068281 (A.A.), U01 HL068290 (R.K.), U01 HL068269 (J.L.), U01 HL068288 (E.R.), and U01 HL068279 (V.V.) from the National Institutes of Health, and by the Ciarnanello Family Fund (A.B., J.N.). The authors declare no conflicts of interest, real or perceived.

 Registered with clinicaltrials.gov (no.) NCT00132080.

PII: S0022-3476(08)00870-6

doi: 10.1016/j.jpeds.2008.10.006

The Journal of Pediatrics
Volume 154, Issue 4 , Pages 592-595.e2 , April 2009

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