The Journal of Pediatrics
Volume 154, Issue 2 , Pages 162-163 , February 2009

Infection, Inflammation, and the Downward Spiral of Cystic Fibrosis Lung Disease

  • Richard B. Moss, MD

      Affiliations

    • Corresponding Author InformationReprint requests: Richard B. Moss, MD, The Center for Excellence in Pulmonary Biology, Department of Pediatrics, Stanford University Medical Center, 770 Welch Road Suite 350, Palo Alto CA 94304-5882

References 

  1. Knowles MR, Boucher RC. Mucus clearance as a primary innate defense mechanism for mammalian airways. J Clin Invest. 2002;109:571–577
  2. Worlitzsch D, Tarran R, Ulrich M, Schwab U, Cekici A, Meyer KC, et al. Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients. J Clin Invest. 2002;109:317–325
  3. Boucher RC. Evidence for airway surface dehydration as the initiating event in CF airway disease. J Intern Med. 2007;261:5–16
  4. Rao S, Grigg J. New insights into pulmonary inflammation in cystic fibrosis. Arch Dis Child. 2006;91:786–788
  5. Machen TE. Innate immune response in CF airway epithelia: hyperinflammatory?. Am J Physiol Cell Physiol. 2006;291:C218–C230
  6. Elizur A, Cannon CL, Ferkol TW. Airway inflammation in cystic fibrosis. Chest. 2008;133:489–495
  7. Nichols D, Chmiel J, Berger M. Chronic inflammation in the cystic fibrosis lung: alterations in inter- and intracellular signaling. Clinic Rev Allerg Immunol. 2008;34:146–162
  8. Jacquot J, Tabary O, Clement A. Hyperinflammation in airways of cystic fibrosis patients: what's new?. Expert Rev Mol Diagn. 2008;8:359–363
  9. Sagel SD, Gibson RL, Emerson J, McNamara S, Burns JL, Wagener JS, et al. Impact of Pseudomonas and Staphylococcal infection on inflammation and clinical status in young children with cystic fibrosis. J Pediatr. 2009;154:183–188
  10. Rosenfeld M, Emerson J, Accurso F, Armstrong D, Castile R, Grimwood K, et al. Diagnostic accuracy of oropharyngeal cultures in infants and young children with cystic fibrosis. Pediatr Pulmonol. 1999;28:321–328
  11. Treggiari MM, Rosenfeld M, Retsch-Bogart G, Gibson R, Ramsey B. Approach to eradication of initial Pseudomonas aeruginosa infection in children with cystic fibrosis. Pediatr Pulmonol. 2007;42:751–756
  12. Stone A, Saiman L. Update on the epidemiology and management of Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus, in patients with cystic fibrosis. Curr Opin Pulm Med. 2007;13:515–521
  13. Steinkamp G, Wiedemann B, Rietschel E, Krahl A, Gielen J, Bärmeier H, et al. Prospective evaluation of emerging bacteria in cystic fibrosis. J Cyst Fibros. 2005;4:41–48
  14. Tunney MM, Field TR, Moriarty TF, Patrick S, Doering G, Muhlebach MS, et al. Detection of anaerobic bacteria in high numbers in sputum from patients with cystic fibrosis. Am J Respir Crit Care Med. 2008;177:995–1001
  15. Harris JK, De Groote MA, Sagel SD, Zemanick ET, Kapsner R, Penvari C, et al. Molecular identification of bacteria in bronchoalveolar lavage fluid from children with cystic fibrosis. Proc Natl Acad Sci USA. 2007;104:20529–20533
  16. Bittar F, Richet H, Dubus JC, Reynaud-Gaubert M, Stremler N, Sarles J, et al. Molecular detection of multiple emerging pathogens in sputa from cystic fibrosis patients. PLoS ONE. 2008;3:e2908
  17. Davis SD, Fordham LA, Brody AS, Noah TL, Retsch-Bogart GZ, Qaqish BF, et al. Computed tomography reflects lower airway inflammation and tracks changes in early cystic fibrosis. Am J Respir Crit Care Med. 2007;175:943–950
  18. Syhre M, Scotter JM, Chambers ST. Investigation into the production of 2-Pentylfuran by Aspergillus fumigatus and other respiratory pathogens in vitro and human breath samples. Med Mycol. 2008;46:209–215

PII: S0022-3476(08)00818-4

doi: 10.1016/j.jpeds.2008.09.042

The Journal of Pediatrics
Volume 154, Issue 2 , Pages 162-163 , February 2009

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