The Journal of Pediatrics
Volume 154, Issue 3 , Pages 345-350.e1 , March 2009

Increased Risks of Congenital, Neurologic, and Endocrine Disorders Associated with Autism in Preschool Children: Cognitive Ability Differences

  • Chuan-Yu Chen, PhD

      Affiliations

    • Division of Mental Health and Substance Abuse Research, National Health Research Institutes, Zhunan, Taiwan
    • National Yang-Ming University, Institute of Public Health and Department of Social Medicine, Taipei, Taiwan
    • Corresponding Author InformationReprint requests: Chuan-Yu Chen, PhD, National Health Research Institutes, Division of Mental Health and Substance Abuse Research, 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan
    • ,
  • Kuang-Hung Chen, MSc

      Affiliations

    • Division of Mental Health and Substance Abuse Research, National Health Research Institutes, Zhunan, Taiwan
    • ,
  • Chieh-Yu Liu, PhD

      Affiliations

    • Department of Nursing, National Taipei College of Nursing, Taipei, Taiwan
    • ,
  • Su-Ling Huang, MSc

      Affiliations

    • Division of Mental Health and Substance Abuse Research, National Health Research Institutes, Zhunan, Taiwan
    • ,
  • Keh-Ming Lin, MD, MPH

      Affiliations

    • Division of Mental Health and Substance Abuse Research, National Health Research Institutes, Zhunan, Taiwan

Received 19 February 2008 ,Revised 4 June 2008 ,Accepted 24 September 2008.

References 

  1. Mugno D, Ruta L, D'Arrigo VG, Mazzone L. Impairment of quality of life in parents of children and adolescents with pervasive developmental disorder. Health Qual Life Outcomes. 2007;5:22
  2. Zhao X, Leotta A, Kustanovich V, Lajonchere C, Geschwind DH, Law K, et al. A unified genetic theory for sporadic and inherited autism. Proc Natl Acad Sci USA. 2007;104:12831–12836
  3. Kaminsky Z, Wang SC, Petronis A. Complex disease, gender and epigenetics. Ann Med. 2006;38:530–544
  4. Rutter M, Sroufe LA. Developmental psychopathology: Concepts and challenges. Dev Psychopathol. 2000;12:265–296
  5. Bartak L, Rutter M. Differences between mentally retarded and normally intelligent autistic children. J Autism Child Schizophr. 1976;6:109–120
  6. Freeman BJ, Ritvo ER, Schroth PC, Tonick I, Guthrie D, Wake L. Behavioral characteristics of high- and low-IQ autistic children. Am J Psychiatry. 1981;138:25–29
  7. Xue Ming, Brimacombe M, Chaaban J, Zimmerman-Bier B, Wagner GC. Autism spectrum disorders: concurrent clinical disorders. J Child Neurol. 2008;23:6–13
  8. Rutter M, Bailey A, Bolton P, Le Couteur A. Autism and known medical conditions: myth and substance. J Child Psychol Psychiatry. 1994;35:311–322
  9. Wier ML, Yoshida CK, Odouli R, Grether JK, Croen LA. Congenital anomalies associated with autism spectrum disorders. Dev Med Child Neurol. 2006;48:500–507
  10. Vargas DL, Nascimbene C, Krishnan C, Zimmerman AW, Pardo CA. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol. 2005;57:67–81
  11. Murch S. Diet, immunity, and autistic spectrum disorders. J Pediatr. 2005;146:582–584
  12. Wills S, Cabanlit M, Bennett J, Ashwood P, Amaral D, Van de Water J. Autoantibodies in autism spectrum disorders (ASD). Ann N Y Acad Sci. 2007;1107:79–91
  13. Ashwood P, Van de Water J. Is autism an autoimmune disease?. Autoimmun Rev. 2004;3:557–562
  14. Fombonne E, Du Mazaubrun C, Cans C, Grandjean H. Autism and associated medical disorders in a French epidemiological survey. J Am Acad Child Adolesc Psychiatr. 1997;36:1561–1569
  15. Lauritsen MB, Mors O, Mortensen PB, Ewald H. Medical disorders among inpatients with autism in Denmark according to ICD-8: A nationwide register-based study. J Autism Dev Disord. 2002;32:115–119
  16. Sperner-Unterweger B. Immunological aetiology of major psychiatric disorders: evidence and therapeutic implications. Drugs. 2005;65:1493–1520
  17. Chen PC, Chien KL, Chang CW, Su TC, Jeng JS, Lee YT, et al. More hemorrhagic and severe events cause higher hospitalization care cost for childhood stroke in Taiwan. J Pediatr. 2008;152:388–393
  18. Sun HL, Kao YH, Lu TH, Chou MC, Lue KH. Health-care utilization and costs in Taiwanese pediatric patients with asthma. Pediatr Int. 2007;49:48–52
  19. Chen CY, Liu CY, Su WC, Huang SL, Lin KM. Factors associated with the diagnosis of neurodevelopmental disorders: A population-based longitudinal study. Pediatrics. 2007;119:e435–e443
  20. World Health Organization. International classification of diseases, 9th revision, clinical modification. Ann Arbor, MI: Commission on Professional and Hospital Activities; 1978;
  21. Liu CY, Hung YT, Chuang YL, Chen YL, Weng YJ, Lin WS, et al. Incorporating development stratification of Taiwan townships into sampling design of large scale health interview survey. J Health Manag. 2006;4:1–22
  22. Chen CY, Liu CY, Su WC, Huang SL, Lin KM. Urbanicity-related variation in help-seeking and services utilization among preschool-age children with autism in Taiwan. J Autism Dev Disord. 2008;38:489–497
  23. SAS (stat) [program], 9.13 version. Cary, NC: SAS Institute Inc; 2000;
  24. STATA statistical software [program], Release 8.02 version. College Station, TX: Stata Corporation; 2005;
  25. Rosen NJ, Yoshida CK, Croen LA. Infection in the first 2 years of life and autism spectrum disorders. Pediatrics. 2007;119:e61–e69
  26. Croen LA, Grether JK, Yoshida CK, Odouli R, Van de Water J. Maternal autoimmune diseases, asthma and allergies, and childhood autism spectrum disorders: A case-control study. Arch Pediatr Adolesc Med. 2005;159:151–157
  27. Sweeten TL, Bowyer SL, Posey DJ, Halberstadt GM, McDougle CJ. Increased prevalence of familial autoimmunity in probands with pervasive developmental disorders. Pediatrics. 2003;112:e420
  28. Wong V. Study of the relationship between tuberous sclerosis complex and autistic disorder. J Child Neurol. 2006;21:199–204
  29. Freeman SJ, Roberts W, Daneman D. Type 1 diabetes and autism: Is there a link?. Diabetes Care. 2005;28:925–926
  30. Newschaffer C, Cole S. Risk factors for autism-perinatal factors, parental psychiatric history, and socioeconomic status. Am J Epidemiol. 2005;161:926–928
  31. Levisohn PM. The autism-epilepsy connection. Epilepsia. 2007;48(s9):33–35
  32. Bolton PF, Veltman MW, Weisblatt E, Holmes JR, Thomas NS, Youings SA, et al. Chromosome 15q11-13 abnormalities and other medical conditions in individuals with autism spectrum disorders. Psychiatr Genet. 2004;14:131–137
  33. Comi AM, Zimmerman AW, Frye VH, Law PA, Peeden JN. Familial clustering of autoimmune disorders and evaluation of medical risk factors in autism. J Child Neurol. 1999;14:388–394
  34. Deonna T, Roulet E. Autistic spectrum disorder: Evaluating a possible contributing or causal role of epilepsy. Epilepsia. 2006;47(S2):79–82
  35. Asano E, Chugani DC, Muzik O, Behen M, Janisse J, Rothermel R, et al. Autism in tuberous sclerosis complex is related to both cortical and subcortical dysfunction. Neurology. 2001;57:1269–1277
  36. Newschaffer CJ, Croen LA, Daniels J, Giarelli E, Grether JK, Levy SE, et al. The epidemiology of autism spectrum disorders. Annu Rev Public Health. 2007;28:235–258
  37. Bailey A, Phillips W, Rutter M. Autism: towards an integration of clinical, genetic, neuropsychological, and neurobiological perspectives. J Child Psychol Psychiatr. 1996;37:89–126

 This work is completely supported by the National Health Research Institutes, which had no involvement in the study design, data collection, analysis, and interpretation, report writing, or the decision to submit the paper for publication. The authors declare no conflicts of interest.

PII: S0022-3476(08)00817-2

doi: 10.1016/j.jpeds.2008.09.043

The Journal of Pediatrics
Volume 154, Issue 3 , Pages 345-350.e1 , March 2009

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