Impact of reactivations in multisystem Langerhans cell histiocytosis

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The clinical impact of reactivations in multisystem Langerhans cell histiocytosis has been studied by Minkov et al from the International LCH Study Group. In a retrospective analysis of 335 patients, the probability of reactivation within 5 years of disease resolution was 46%. The locations of the different recurrences are reported, many of which were skeletal. The mortality associated with the first reactivation was 2.2%. In the majority, a second remission was achieved and the probability of a second reactivation within 5 years was 44%. The risk of permanent consequences was greater in patients with reactivations compared with those without reactivations. The authors discuss the need for further prospective trials.

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