The Journal of Pediatrics
Volume 154, Issue 3 , Pages 332-337.e2 , March 2009

Risk Factors for Extreme Events in Infants Hospitalized for Apparent Life-threatening Events

Received 17 June 2008 ,Revised 23 July 2008 ,Accepted 28 August 2008.

References 

  1. National Institutes of Health Consensus Development Conference on Infantile Apnea and Home Monitoring, Sept 29 to Oct 1, 1986. Pediatrics. 1987;79:292–299
  2. Kahn A European Society for the Study and Prevention of Infant Death. Recommended clinical evaluation of infants with an apparent life-threatening event (Consensus document of the European Society for the Study and Prevention of Infant Death, 2003). Eur J Pediatr. 2004;163:108–115
  3. McGovern MC, Smith MBH. Causes of apparent life threatening events in infants: a systematic review. Arch Dis Child. 2004;89:1043–1048
  4. Cote A, Hum C, Brouillette RT, Themens M. Frequency and timing of recurrent events in infants using home cardiorespiratory monitors. J Pediatr. 1998;132:783–789
  5. Ramanathan R, Corwin MJ, Hunt CE, Lister G, Tinsley LR, Baird T, et al. Cardiorespiratory events recorded on home monitors—Comparison of healthy infants with those at increased risk for SIDS. JAMA. 2001;285:2199–2207
  6. Stebbens VA, Poets CF, Alexander JR, Arrowsmith WA, Southall DP. Oxygen-saturation and breathing patterns in infancy.1 (Full term infants in the 2nd month of life). Arch Dis Child. 1991;66:569–573
  7. Poets CF, Stebbens VA, Southall DP. Arterial oxygen-saturation and breathing movements during the 1st year of life. J Dev Physiol. 1991;15:341–345
  8. Poets CF, Stebbens VA, Lang JA, Obrien LM, Boon AW, Southall DP. Arterial oxygen saturation in healthy term neonates. Eur J Pediatr. 1996;155:219–223
  9. Hunt CE, Hufford DR, Bourguignon C, Oess MA. Home documented monitoring of cardiorespiratory pattern and oxygen saturation in healthy infants. Pediatr Res. 1996;39:216–222
  10. Hunt CE, Corwin MJ, Lister G, Weese-Mayer DE, Neuman MR, Tinsley L, et al. Longitudinal assessment of hemoglobin oxygen saturation in healthy infants during the first 6 months. J Pediatr. 1999;135:580–586
  11. Darnall RA, Ariagno RL, Kinney HC. The late preterm infant and the control of breathing, sleep, and brainstem development: a review. Clin Perinatol. 2006;33:883–914
  12. Gaultier C, Gallego J. Development of respiratory control: evolving concepts and perspectives. Respir Physiol Neurobiol. 2005;149:3–15
  13. Thach BT. Some aspects of clinical relevance in the maturation of respiratory control in infants. J Appl Physiol. 2008;104:1828–1834
  14. Horne RS, Parslow PM, Harding R. Respiratory control and arousal in sleeping infants. Paediatr Respir Rev. 2004;5:190–198
  15. Horne RS, Parslow PM, Harding R. Postnatal development of ventilatory and arousal responses to hypoxia in human infants. Respir Physiol Neurobiol. 2005;149:257–271
  16. Thach BT. Maturation and transformation of reflexes that protect the laryngeal airway from liquid aspiration from fetal to adult life. Am J Med. 2001;111(Suppl 8A):69-77S
  17. Reix P, St-Hilaire M, Praud JP. Laryngeal sensitivity in the neonatal period: from bench to bedside. Pediatr Pulmonol. 2007;42:674–682
  18. Praud JP, Reix P. Upper airways and neonatal respiration. Respir Physiol Neurobiol. 2005;149:131–141
  19. Hoppenbrouwers T, Hodgman JE, Harper RM, Sterman MB. Respiration during the first six months of life in normal infants: IV (Gender differences). Early Hum Dev. 1980;4:167–177
  20. Thoman EB, Freese MP, Becker PT, Acebo C, Morin VN, Tynan WD. Sex differences in the ontogeny of sleep apnea during the first year of life. Physiol Behav. 1978;20:699–707
  21. Leuschen MP, Willett LD, Bolam DL, Nelson RM. Plasma beta-endorphin in neonates: effect of prematurity, gender, and respiratory status. J Clin Endocrinol Metab. 1991;73:1062–1066
  22. Bruhn FW, Mokrohisky ST, McIntosh K. Apnea associated with respiratory syncytial virus infection in young infants. J Pediatr. 1977;90:382–386
  23. Church NR, Anas NG, Hall CB, Brooks JG. Respiratory syncytial virus-related apnea in infants (Demographics and outcome). Am J Dis Child. 1984;138:247–250
  24. Kneyber MC, Brandenburg AH, de Groot R, Joosten KF, Rothbarth PH, Moll HA. Risk factors for respiratory syncytial virus associated apnoea. Eur J Pediatr. 1998;157:331–335
  25. Wilwerth BM, Harper MB, Greenes DS. Identifying hospitalized infants who have bronchiolitis and are at high risk for apnea. Ann Emerg Med. 2006;48:441–447
  26. Lindgren C, Grogaard J. Reflex apnea response and inflammatory mediators in infants with respiratory tract infection. Acta Paediatr. 1996;85:798–803
  27. Lindgren C. Respiratory control during upper airway infection (Mechanism for prolonged reflex apnoea and sudden infant death with special reference to infant sleep position). FEMS Immunol Med Microbiol. 1999;25:97–102
  28. Poets CF, Stebbens VA, Alexander JR, Arrowsmith WA, Salfield SAW, Southall DP. Hypoxemia in infants with respiratory tract infections. Acta Paediatr. 1992;81:536–541
  29. Gélinas J-F, Davis GM, Arlegui C, Côté A. Prolonged, documented home-monitoring of oxygenation in infants and children. Pediatr Pulmonol. 2008;43:288–296
  30. Claudius I, Keens T. Do all infants with apparent life-threatening events need to be admitted?. Pediatrics. 2007;119:679–683
  31. Goldberg S, Schwartz S, Picard E. Do all infants with apparent life-threatening events need to be admitted?. Pediatrics. 2007;120:448
  32. Davies F, Gupta R. Apparent life threatening events in infants presenting to an emergency department. Emerg Med J. 2002;19:11–16
  33. De Piero AD, Teach SJ, Chamberlain JM. ED evaluation of infants after an apparent life-threatening event. Am J Emerg Med. 2004;22:83–86
  34. Southall DP, Levitt GA, Richards JM, Jones RA, Kong C, Frandon PA, et al. Undetected episodes of prolonged apnea and severe bradycardia in preterm infants. Pediatrics. 1983;72:541–551
  35. Poets CF, Stebbens VA, Richard D, Southall DP. Prolonged episodes of hypoxemia in preterm infants undetectable by cardiorespiratory monitors. Pediatrics. 1995;95:860–863
  36. Gray C, Davies F, Molyneux E. Apparent life-threatening events presenting to a pediatric emergency department. Pediatr Emerg Care. 1999;15:195–199

 Supported in part by the Réseau en santé respiratoire (Respiratory Health Network) of the Fonds de la recherché en santé du Québec. The authors declare no conflicts of interest, real or perceived.Dr Al-Kindy is presently at the Child Health Department, Sultan Qaboos University Hospital, Sultanate of Oman.

PII: S0022-3476(08)00762-2

doi: 10.1016/j.jpeds.2008.08.051

The Journal of Pediatrics
Volume 154, Issue 3 , Pages 332-337.e2 , March 2009