The Journal of Pediatrics
Volume 154, Issue 3 , Pages 401-408.e1 , March 2009

Associations between Multiple Environmental Exposures and Glutathione S-transferase P1 on Persistent Wheezing in a Birth Cohort

  • Kathy T. Schroer, BS

      Affiliations

    • Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
    • Molecular and Developmental Biology, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, OH
    • ,
  • Jocelyn M. Biagini Myers, PhD

      Affiliations

    • Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
    • Environmental Health, University of Cincinnati, Cincinnati, OH
    • ,
  • Patrick H. Ryan, PhD

      Affiliations

    • Environmental Health, University of Cincinnati, Cincinnati, OH
    • ,
  • Grace K. LeMasters, PhD

      Affiliations

    • Environmental Health, University of Cincinnati, Cincinnati, OH
    • ,
  • David I. Bernstein, MD

      Affiliations

    • Internal Medicine, University of Cincinnati, Cincinnati, OH
    • ,
  • Manuel Villareal, MD

      Affiliations

    • Internal Medicine, University of Cincinnati, Cincinnati, OH
    • ,
  • James E. Lockey, MD, MS

      Affiliations

    • Environmental Health, University of Cincinnati, Cincinnati, OH
    • ,
  • Tiina Reponen, PhD

      Affiliations

    • Environmental Health, University of Cincinnati, Cincinnati, OH
    • ,
  • Sergey Grinshpun, PhD

      Affiliations

    • Environmental Health, University of Cincinnati, Cincinnati, OH
    • ,
  • Gurjit K. Khurana Hershey, MD, PhD

      Affiliations

    • Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
    • Department of Pediatrics, University of Cincinnati, Cincinnati, OH
    • Corresponding Author InformationReprint requests: Gurjit K. Khurana Hershey, MD, PhD, Division of Asthma Research, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., MLC 7037, Cincinnati, OH 45229-3039

Received 5 December 2007 ,Revised 26 June 2008 ,Accepted 18 August 2008.

References 

  1. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC (The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee). Lancet. 1998;351:1225–1232
  2. Ryan PH, LeMasters GK, Biswas P, Levin L, Hu S, Lindsey M, et al. A comparison of proximity and land use regression traffic exposure models and wheezing in infants. Environ Health Perspect. 2007;115:278–284
  3. World Health Organization (www.who.int). WHO Regional Office for Europe, 2004; Health aspects of air pollution. Results from the WHO project “Systemic review of health aspects of air pollution in Europe.” Available from: www.euro.who.int/document/E83080.pdf.
  4. Biagini JM, LeMasters GK, Ryan PH, Levin L, Reponen T, Bernstein DI, et al. Environmental risk factors of rhinitis in early infancy. Pediatr Allergy Immunol. 2006;17:278–284
  5. Huang MF, Lin WL, Ma YC. A study of reactive oxygen species in mainstream of cigarette. Indoor Air. 2005;15:135–140
  6. Riedl M, Diaz-Sanchez D. Biology of diesel exhaust effects on respiratory function. J Allergy Clin Immunol. 2005;115:221–228quiz 9
  7. Iossifova YY, Reponen T, Bernstein DI, Levin L, Kalra H, Campo P, et al. House dust (1-3)-beta-D-glucan and wheezing in infants. Allergy. 2007;62:504–513
  8. Gilliland FD, Gauderman WJ, Vora H, Rappaport E, Dubeau L. Effects of glutathione-S-transferase M1, T1, and P1 on childhood lung function growth. Am J Respir Crit Care Med. 2002;166:710–716
  9. Fryer AA, Bianco A, Hepple M, Jones PW, Strange RC, Spiteri MA. Polymorphism at the glutathione S-transferase GSTP1 locus (A new marker for bronchial hyperresponsiveness and asthma). Am J Respir Crit Care Med. 2000;161:1437–1442
  10. Mannervik B, Awasthi YC, Board PG, Hayes JD, Di Ilio C, Ketterer B, et al. Nomenclature for human glutathione transferases. Biochem J. 1992;282(Pt 1):305–306
  11. Pemble SE, Taylor JB. An evolutionary perspective on glutathione transferases inferred from class-theta glutathione transferase cDNA sequences. Biochem J. 1992;287(Pt 3):957–963
  12. Fryer AA, Hume R, Strange RC. The development of glutathione S-transferase and glutathione peroxidase activities in human lung. Biochim Biophys Acta. 1986;883:448–453
  13. Kano T, Sakai M, Muramatsu M. Structure and expression of a human class pi glutathione S-transferase messenger RNA. Cancer Res. 1987;47:5626–5630
  14. Doull IJ, Lawrence S, Watson M, Begishvili T, Beasley RW, Lampe F, et al. Allelic association of gene markers on chromosomes 5q and 11q with atopy and bronchial hyperresponsiveness. Am J Respir Crit Care Med. 1996;153:1280–1284
  15. Ahmad H, Wilson DE, Fritz RR, Singh SV, Medh RD, Nagle GT, et al. Primary and secondary structural analyses of glutathione S-transferase pi from human placenta. Arch Biochem Biophys. 1990;278:398–408
  16. Watson MA, Stewart RK, Smith GB, Massey TE, Bell DA. Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution. Carcinogenesis. 1998;19:275–280
  17. LeMasters GK, Wilson K, Levin L, Biagini J, Ryan P, Lockey JE, et al. High prevalence of aeroallergen sensitization among infants of atopic parents. J Pediatr. 2006;149:505–511
  18. Asher MI, Keil U, Anderson HR, Beasley R, Crane J, Martinez F, et al. International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. Eur Respir J. 1995;8:483–491
  19. Martuzevicius D, Grinshpun SA, Reponen T, Gorny RL, Shukla R, Lockey J, et al. Spatial and temporal variations of PM2.5 concentration and composition throughout an urban area with high freeway density-the Greater Cincinnati study. Atmospheric Environment. 2004;38:1091–1105
  20. Hu S, McDonald R, Martuzevicius D, Biswas P, Turner J, Kelly A, et al. UNMIX calculations of ambient PM2.5 near an interstate highway in the greater Cincinnati area. Atmospheric Environment. 2005;40:378–395
  21. Cho SH, Reponen T, LeMasters G, Levin L, Huang J, Meklin T, et al. Mold damage in homes and wheezing in infants. Ann Allergy Asthma Immunol. 2006;97:539–545
  22. Gilliland FD, Li YF, Gong H, Diaz-Sanchez D. Glutathione-S-Transferase M1 and P1 Prevent Aggravation of Allergic Responses by Secondhand Smoke. Am J Respir Crit Care Med. 2006;
  23. Gilliland FD, Rappaport EB, Berhane K, Islam T, Dubeau L, Gauderman WJ, et al. Effects of glutathione S-transferase P1, M1, and T1 on acute respiratory illness in school children. Am J Respir Crit Care Med. 2002;166:346–351
  24. Vachier I, Damon M, Le Doucen C, de Paulet AC, Chanez P, Michel FB, et al. Increased oxygen species generation in blood monocytes of asthmatic patients. Am Rev Respir Dis. 1992;146:1161–1166
  25. Owen S, Pearson D, Suarez-Mendez V, O'Driscoll R, Woodcock A. Evidence of free-radical activity in asthma. N Engl J Med. 1991;325:586–587
  26. von Mutius E. Environmental factors influencing the development and progression of pediatric asthma. J Allergy Clin Immunol. 2002;109:S525–S532
  27. Jussila J, Komulainen H, Huttunen K, Roponen M, Halinen A, Hyvarinen A, et al. Inflammatory responses in mice after intratracheal instillation of spores of Streptomyces californicus isolated from indoor air of a moldy building. Toxicol Appl Pharmacol. 2001;171:61–69
  28. Jaakkola JJ, Jaakkola N, Ruotsalainen R. Home dampness and molds as determinants of respiratory symptoms and asthma in pre-school children. J Expo Anal Environ Epidemiol. 1993;3(Suppl 1):129–142
  29. Nel AE, Diaz-Sanchez D, Li N. The role of particulate pollutants in pulmonary inflammation and asthma: evidence for the involvement of organic chemicals and oxidative stress. Curr Opin Pulm Med. 2001;7:20–26
  30. Leem JH, Kim JH, Lee KH, Hong Y, Lee KH, Kang D, et al. Asthma attack associated with oxidative stress by exposure to ETS and PAH. J Asthma. 2005;42:463–467
  31. Hayes JD, Pulford DJ. The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol. 1995;30:445–600
  32. De Sario M, Di Domenicantonio R, Corbo G, Forastiere F, Pistelli R, Rusconi F, et al. Characteristics of early transient, persistent, and late onset wheezers at 9 to 11 years of age. J Asthma. 2006;43:633–638

 Supported by NIEHS R01 ES11170 and ES10957. The authors declare no conflicts of interest.

PII: S0022-3476(08)00706-3

doi: 10.1016/j.jpeds.2008.08.040

The Journal of Pediatrics
Volume 154, Issue 3 , Pages 401-408.e1 , March 2009

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