The Journal of Pediatrics
Volume 154, Issue 1 , Pages 5-7 , January 2009

RBP4: From Retinol Transporter to Biomarker?

  • Sandra Hassink, MD

      Affiliations

    • Alfred I. DuPont Hospital for Children, Department of Pediatrics, Wilmington, Delaware
    • Corresponding Author InformationReprint requests: Sandra Hassink, MD, Alfred I. DuPont Hospital for Children, Department of Pediatrics, 1600 Rockland Rd, Wilmington, DE 19899
    • ,
  • Prabhakaran (Babu) Balagopal, PhD

      Affiliations

    • Nemours Children's Clinic, Jacksonville, Florida

References 

  1. Kanai M, Raz A, Goodman DS. Retinol-binding protein: the transport protein for vitamin A in human plasma. J Clin Invest. 1968;47:2025–2044
  2. Goodman DS. Plasma retinol-binding protein. Ann N Y Acad Sci. 1980;348:378–390
  3. Tsutsumi C, Okuno M, Tannous L, Piantedosi R, Allan M, Goodman DS, et al. Retinoids and retinoid-binding protein expression in rat adipocytes. J Biol Chem. 1992;267:1805–1810
  4. Zovich DC, Orloga A, Okuno M, Kong LW, Talmage DA, Piantedosi R, et al. Differentiation-dependent expression of retinoid-binding proteins in BFC-1[beta] adipocytes. J Biol Chem. 1992;267:13884–13889
  5. Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005;436:356–362
  6. Graham TE, Yang Q, Bluher M, Hammarstedt A, Ciaraldi TP, Henry RR, et al. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med. 2006;354:2552–2563
  7. Munkhtulga L, Nakayama K, Utsumi N, Yanagisawa Y, Gotoh T, Omi T, et al. Identification of a regulatory SNP in the retinol binding protein 4 gene associated with type 2 diabetes in Mongolia. Hum Genet. 2007;120:879–888
  8. Craig RL, Chu WS, Elbein SC. Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate traits. Mol Genet Metab. 2007;90:338–344
  9. van Hoek M, Dehghan A, Zillikens MC, Hofman A, Witteman A, Sijbrands EJG. An RBP4 promoter polymorphism increases risk of type 2 diabetes. Diabetologia. 2008;51:1423–1428
  10. Takebayashi K, Aso Y, Inukai T. The role of retinol binding protein in the pathogenesis of type 2 diabetes. Expert Review Endocrinology Metabolism. 2008;3:1161–1173
  11. Graham T, Wason C, Bl++her M, Kahn B. Shortcomings in methodology complicate measurements of serum retinol binding protein (RBP4) in insulin-resistant human subjects. Diabetologia. 2007;50:814–823
  12. Janke J, Engeli S, Boschmann M, Adams F, Bohnke J, Luft FC, et al. Retinol-binding protein 4 in human obesity. Diabetes. 2006;55:2805–2810
  13. Balagopal P, Graham TE, Kahn BB, Altomare A, Funanage V, George D. Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: association with subclinical inflammation. J Clin Endocrinol Metab. 2007;92:1971–1974
  14. Gavi S, Qurashi S, Stuart LM, Lau R, Melendez MM, Mynarcik DC, et al. Influence of age on the association of retinol-binding protein 4 with metabolic syndrome. Obesity. 2008;16:893–895
  15. Lee DC, Lee JW, Im JA. Association of serum retinol binding protein 4 and insulin resistance in apparently healthy adolescents. Metabolism. 2007;56:327–331
  16. Aeberli I, Biebinger R, Lehmann R, l'Allemand D, Spinas GA, Zimmermann MB. Serum retinol-binding protein 4 concentration and its ratio to serum retinol are associated with obesity and metabolic syndrome components in children. J Clin Endocrinol Metab. 2007;92:4359–4365
  17. Reinehr T, Stoffel-Wagner B, Roth CL. Retinol-binding protein 4 and its relation to insulin resistance in obese children before and after weight loss. J Clin Endocrinol Metab. 2008;93:2287–2293
  18. Goodman E, Graham TE, Dolan LM, Daniels SR, Goodman ER, Kahn BB. The relationship of retinol binding protein 4 to changes in insulin resistance and cardiometabolic risk in overweight black Americans. J Pediatr. 2009;154:67–73
  19. Yao-Borengasser A, Varma V, Bodles AM, Rasouli N, Phanavanh B, Lee MJ, et al. Retinol binding protein 4 expression in humans: relationship to insulin resistance, inflammation, and response to pioglitazone. J Clin Endocrinol Metab. 2007;92:2590–2597

PII: S0022-3476(08)00703-8

doi: 10.1016/j.jpeds.2008.08.024

The Journal of Pediatrics
Volume 154, Issue 1 , Pages 5-7 , January 2009

Article Tools