The Journal of Pediatrics
Volume 154, Issue 2 , Pages 248-252 , February 2009

Addition of pH-Impedance Monitoring to Standard pH Monitoring Increases the Yield of Symptom Association Analysis in Infants and Children with Gastroesophageal Reflux

  • Clara M. Loots, MsC

      Affiliations

    • Academic Medical Centre, Amsterdam, The Netherlands
    • Corresponding Author InformationReprint requests: Clara Maria Loots, Motility Center, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    • ,
  • Marc A. Benninga, MD, PhD

      Affiliations

    • Academic Medical Centre, Amsterdam, The Netherlands
    • ,
  • Geoffrey P. Davidson, MBBS, MD, FRACP

      Affiliations

    • Women's and Children's Hospital, Adelaide, Australia
    • Department of Paediatrics, University of Adelaide, Adelaide, Australia
    • ,
  • Taher I. Omari, PhD

      Affiliations

    • Women's and Children's Hospital, Adelaide, Australia
    • Department of Paediatrics, University of Adelaide, Adelaide, Australia

Received 25 May 2008 ,Revised 7 July 2008 ,Accepted 8 August 2008.

References 

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  2. Poets C. Gastroesophageal reflux: a critical review of its role in preterm infants. Pediatrics. 2004;113:e128–e132
  3. Hila A, Agrawal A, Castell DO. Combined multichannel intraluminal impedance and pH esophageal testing compared to pH alone for diagnosing both acid and weakly acidic gastroesophageal reflux. Clin Gastroenterol Hepatol. 2007;5:172–177
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  9. Tutuian R, Castell DO. Review article: complete gastro-oesophageal monitoring combined pH and impedance. Aliment Pharmacol Ther. 2006;24:27–37
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  11. Woodley F, Mousa H. Acid gastroesophageal reflux reports in infants: a comparison of esophageal pH monitoring and multichannel intraluminal impedance measurements. Dig Dis Sci. 2006;51:1910–1916
  12. Bredenoord A, Weusten BL, Timmer R, Conchillo JM, Smout AJ. Addition of esophageal impedance monitoring to pH monitoring increases the yield of symptom association analysis in patients off PPI therapy. Am J Gastroenterol. 2006;101:453–459
  13. Zerbib F, Roman S, Ropert A, des Varannes SB, Pouderoux P, Chaput U, et al. Esophageal pH-impedance monitoring and symptom analysis in GERD: a study in patients off and on therapy. Am J Gastroenterol. 2006;101:1956–1963
  14. Vandenplan Y, Salvatore S, Vieira MC, Hauser B. Will esophageal impedance replace pH monitoring?. Pediatrics. 2007;119:118–122
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  16. Weusten B, Roelofs JM, Akkermans LM, Van Berge-Henegouwen GP, Smout AJ. The symptom-association probability: an improved method for symptom analysis of 24-hour esophageal pH data. Gastroenterology. 1994;107:1741–1745
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  19. Weusten BL, Roelofs JM, Akkermans LM, Van Berge-Henegouwen GP, Smout AJ. The symptom-association probability: an improved method for symptom analysis of 24-hour esophageal pH data. Gastroenterology. 1994;107:1741–1745
  20. Diaz SAR, Clouse RE, et al. The symptom association probability (SAP) is superior to the symptom index (SI) for attributing symptoms to gastroesophageal reflux: validation using outcome from laparoscopic antireflux surgery (LARS). Gastroenterology. 2002;122:A75
  21. Taghavi SA, Ghasedi M, Saberi-Firoozi M, Alizadeh-Naeeni M, Bagheri-Lankarani K, Kaviani MJ, et al. Symptom association probability and symptom sensitivity index: preferable but still suboptimal predictors of response to high dose omeprazole. Gut. 2005;54:1067–1071
  22. Watson RG, Tham TC, Johnston BT, McDougall NI. Double blind cross-over placebo controlled study of omeprazole in the treatment of patients with reflux symptoms and physiological levels of acid reflux—the “sensitive oesophagus.”. Gut. 1997;40:587–590
  23. Omari TI, Barnett CP, Benninga MA, Lontis R, Goodchild L, Haslam RR, et al. Mechanisms of gastro-oesophageal reflux in preterm and term infants with reflux disease. Gut. 2002;51:475–479
  24. Omari TI, Benninga MA, Sansom L, Butler RN, Dent J, Davidson GP. Effect of baclofen on esophagogastric motility and gastroesophageal reflux in children with gastroesophageal reflux disease: a randomized controlled trial. J Pediatr. 2006;149:468–474
  25. Omari TI, Rommel N, Staunton E, Lontis R, Goodchild L, Haslam RR, et al. Paradoxical impact of body positioning on gastroesophageal reflux and gastric emptying in the premature neonate. J Pediatr. 2004;145:194–200

 Dr Taher Omari is a member of the advisory board for Sandhill Scientific and received research funding by Sandhill Scientific. Sandhill Scientific had no role in the conception and preparation of this article.

PII: S0022-3476(08)00700-2

doi: 10.1016/j.jpeds.2008.08.019

The Journal of Pediatrics
Volume 154, Issue 2 , Pages 248-252 , February 2009

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