The Journal of Pediatrics
Volume 154, Issue 1 , Pages 33-38.e2, January 2009

The Infant Behavioral Assessment and Intervention Program for Very Low Birth Weight Infants at 6 Months Corrected Age

  • Karen Koldewijn, PT

      Affiliations

    • Department of Rehabilitation, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • Corresponding Author InformationReprint requests: Karen Koldewijn, Department of Rehabilitation, Academic Medical Center, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    • ,
  • Marie-Jeanne Wolf, PhD

      Affiliations

    • Department of Rehabilitation, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • Department of Neonatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Aleid van Wassenaer, MD, PhD

      Affiliations

    • Department of Neonatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Dominique Meijssen, MSc

      Affiliations

    • Department of Pediatric Psychology, Tilburg University, Tilburg, The Netherlands
    • ,
  • Loekie van Sonderen, MD

      Affiliations

    • Department of Neonatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Anneloes van Baar, PhD

      Affiliations

    • Department of Pediatric Psychology, Tilburg University, Tilburg, The Netherlands
    • ,
  • Anita Beelen, PhD

      Affiliations

    • Department of Rehabilitation, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Frans Nollet, MD, PhD

      Affiliations

    • Department of Rehabilitation, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Joke Kok, MD, PhD

      Affiliations

    • Department of Neonatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Received 9 January 2008; received in revised form 13 June 2008; accepted 17 July 2008. published online 11 September 2008.

Objective

To determine whether the Infant Behavioral Assessment and Intervention Program (IBAIP), designed to support and enhance infants' self-regulatory competence, improved developmental and neurobehavioral outcomes in very low birth weight (VLBW) infants.

Study design

We randomized 86 infants to 1 intervention before discharge and to 6 to 8 home interventions until 6 months corrected age, and 90 control infants received standard care. Developmental and behavioral outcomes were evaluated at 6 months corrected age with the Bayley Scales of Infant Development-II (BSID-II). Neurobehavioral functioning was evaluated with the Infant Behavioral Assessment (IBA) at baseline and at 6 months corrected age.

Results

Despite randomization, some differences in neonatal characteristics were found between the intervention and control infants. After adjustment, intervention effects of 7.2 points (± standard error 3.1) on the Mental Developmental Index and 6.4 ± 2.4 points on the Psychomotor Developmental Index favored the intervention infants. The Behavioral Rating Scale of the BSID-II (P = .000) and the IBA (more approach [P = .003] and less stress [P = .001] over time) also favored the intervention infants.

Conclusions

The IBAIP improved the mental, motor, and behavioral outcomes of VLBW infants at 6 months corrected age.

Abbreviations: BRS, Behavioral Rating Scale, BSID-II, Bayley Scales of Infant Development, GA, Gestational age, IBA, Infant Behavioral Assessment, IBAIP, Infant Behavioral Assessment and Intervention Program, MDI, Mental Developmental Index, NIDCAP, Newborn Individualized Developmental Care and Assessment Program, PDI, Psychomotor Developmental Index, VLBW, Very low birth weight

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 Supported by grants from the Innovatiefonds Zorgverzekeraars (project 576, supporting the implementation of the intervention program) and Zorg Onderzoek Nederland (project 62200032, supporting the first author, who wrote the first draft of the manuscript). The sponsors had no involvement in study design; collection, analysis, or interpretation of the data; writing of the report; or the decision to submit the manuscript for publication. The authors declare no conflicts of interest.

 The trial is registered with controlled-trials.com (ISRCTN65503576).

PII: S0022-3476(08)00603-3

doi:10.1016/j.jpeds.2008.07.039

The Journal of Pediatrics
Volume 154, Issue 1 , Pages 33-38.e2, January 2009

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