The Journal of Pediatrics
Volume 154, Issue 1 , Pages 67-73.e1 , January 2009

The Relationship of Retinol Binding Protein 4 to Changes in Insulin Resistance and Cardiometabolic Risk in Overweight Black Adolescents

  • Elizabeth Goodman, MD

      Affiliations

    • The Floating Hospital for Children at Tufts Medical Center, Boston, MA
    • Department of Pediatrics and Public Health, Tufts University School of Medicine, Boston, MA
    • Corresponding Author InformationReprint requests: Elizabeth Goodman, MD, Pediatric Clinical Research Center, Floating Hospital for Children at Tufts Medical Center, 800 Washington St, Box 854, Boston, MA 02111
    • ,
  • Timothy E. Graham, MD

      Affiliations

    • Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA
    • ,
  • Lawrence M. Dolan, MD

      Affiliations

    • Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
    • ,
  • Stephen R. Daniels, MD, PhD

      Affiliations

    • Department of Pediatrics, University of Denver School of Medicine, Denver, CO
    • ,
  • Eric R. Goodman, BS

      Affiliations

    • The Floating Hospital for Children at Tufts Medical Center, Boston, MA
    • ,
  • Barbara B. Kahn, MD

      Affiliations

    • Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA

Received 7 April 2008 ,Revised 16 June 2008 ,Accepted 15 July 2008.

References 

  1. DeFronzo RA, Ferrannini E. Insulin resistance (A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease). Diabetes Care. 1991;14:173–194
  2. Goodman DS. Plasma retinol-binding protein. Ann N Y Acad Sci. 1980;348:378–390
  3. Kanai M, Raz A, Goodman DS. Retinol-binding protein: the transport protein for vitamin A in human plasma. J Clin Invest. 1968;47:2025–2044
  4. Tsutsumi C, Okuno M, Tannous L, Piantedosi R, Allan M, Goodman DS, et al. Retinoids and retinoid-binding protein expression in rat adipocytes. J Biol Chem. 1992;267:1805–1810
  5. Kloting N, Graham TE, Berndt J, Kralisch S, Kovacs P, Wason CJ, et al. Serum retinol binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass. Cell Metab. 2007;6:79–87
  6. Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005;436:356–362
  7. Graham TE, Yang Q, Bluher M, Hammarstedt A, Ciaraldi TP, Henry RR, et al. Retinolbinding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med. 2006;354:2552–2563
  8. Balagopal P, Graham TE, Kahn BB, Altomare A, Funanage V, George D. Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: association with subclinical inflammation. J Clin Endocrinol Metab. 2007;92:1971–1974
  9. Lee DC, Lee JW, Im JA. Association of serum retinol binding protein 4 and insulin resistance in apparently healthy adolescents. Metabolism. 2007;56:327–331
  10. Takebayashi K, Suetsugu M, Wakabayashi S, Aso Y, Inukai T. Retinol binding protein-4 levels and clinical features of type 2 diabetes patients. J Clin Endocrinol Metab. 2007;92:2712–2719
  11. Qi Q, Yu Z, Ye X, Zhao F, Huang P, Hu FB, et al. Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people. J Clin Endocrinol Metab. 2007;92:4827–4834
  12. Aeberli I, Biebinger R, Lehmann R, l'Allemand D, Spinas GA, Zimmermann MB. Serum retinol-binding protein 4 concentration and its ratio to serum retinol are associated with obesity and metabolic syndrome components in children. J Clin Endocrinol Metab. 2007;92:4359–4365
  13. Craig RL, Chu WS, Elbein SC. Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate traits. Mol Genet Metab. 2007;90:338–344
  14. Kovacs P, Geyer M, Berndt J, Kloting N, Graham TE, Bottcher Y, et al. Effects of genetic variation in the human retinol binding protein-4 gene (RBP4) on insulin resistance and fat depot specific mRNA expression. Diabetes. 2007;65:3095–3100
  15. The Writing Group for the Search for Diabetes in Youth Study Writing Group. Incidence of diabetes in youth in the United States. JAMA. 2007;297:2716–2724
  16. Goodman E, Daniels SR, Dolan LM. Socioeconomic disparities in insulin resistance: results from the Princeton School District Study. Psychosomat Med. 2007;69:61–67
  17. Folsom AR, Qamhieh HT, Flack JM, Hilner JE, Liu K, Howard BV, et al. Plasma fibrinogen: levels and correlates in young adults (The Coronary Artery Risk Development in Young Adults (CARDIA) Study). Am J Epidemiol. 1993;138:1023–1036
  18. Goodman E, Adler NE, Daniels SR, Morrison JA, Slap GB, Dolan LM. Impact of objective and subjective social status on obesity in a biracial cohort of adolescents. Obes Res. 2003;11:1018–1026
  19. Goodman E, McEwen BS, Huang B, Dolan LM, Adler NE. Social inequalities in biomarkers of cardiovascular risk in adolescence. Psychosomat Med. 2005;67:9–15
  20. Goodman E, Daniels SR, Morrison JA, Huang B, Dolan LM. Contrasting prevalence of and demographic disparities in the World Health Organization and National Cholesterol Education Program Adult Treatment Panel III definitions of metabolic syndrome among adolescents. J Pediatr. 2004;145:445–451
  21. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  22. Gungor N, Saad R, Janosky J, Arslanian S. Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents. J Pediatr. 2004;144:47–55
  23. Keskin M, Kurtoglu S, Kendirci M, Atabek ME, Yazici C. Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics. 2005;115:e500–e503
  24. Uwaifo GI, Fallon EM, Chin J, Elberg J, Parikh SJ, Yanovski JA. Indices of insulin action, disposal, and secretion derived from fasting samples and clamps in normal glucose-tolerant black and white children. Diabetes Care. 2002;25:2081–2087
  25. Graham TE, Wason CJ, Bluher M, Kahn BB. Shortcomings in methodology complicate measurements of serum retinol binding protein (RBP4) in insulin-resistant human subjects. Diabetologia. 2007;50:814–823
  26. SPSS. SPSS Base 10.0 User's Guide. Chicago: SPSS, Inc; 1999;
  27. Lee JM, Okumura MJ, Davis MM, Herman WH, Gurney JG. Prevalence and determinants of insulin resistance among U.S. adolescents: a population-based study. Diabetes Care. 2006;29:2427–2432
  28. Szadkowska A, Pietrzak I, Mianowska B, Bodalska-Lipińska J, Keenan HA, Toporowska-Kowalska E, et al. Insulin sensitivity in type 1 diabetic children and adolescents. Diabet Med. 2008;25:282–288
  29. Jia W, Wu H, Bao Y, Wang C, Lu J, Zhu J, et al. Association of serum retinol-binding protein 4 and visceral adiposity in Chinese subjects with and without type 2 diabetes. J Clin Endocrinol Metab. 2007;92:3224–3229
  30. Haider DG, Schindler K, Prager G, Bohdjalian A, Luger A, Wolzt M, et al. Serum retinol-binding protein 4 is reduced after weight loss in morbidly obese subjects. J Clin Endocrinol Metab. 2007;92:1168–1171
  31. Yao-Borengasser A, Varma V, Bodles AM, Rasouli N, Phanavanh B, Lee MJ, et al. Retinol binding protein 4 expression in humans: relationship to insulin resistance, inflammation, and response to pioglitazone. J Clin Endocrinol Metab. 2007;92:2590–2597
  32. Takashima N, Tomoike H, Iwai N. Retinol-binding protein 4 and insulin resistance. N Engl J Med. 2006;355:1392
  33. Erikstrup C, Mortensen OH, Pedersen BK. Retinol-binding protein 4 and insulin resistance. N Engl J Med. 2006;355:1393–1394

 Supported by NIH grants HD41527, DK59183, DK43051, DK69624, and M01RR 08084. B.B.K. is the recipient of a research grant from Takeda Pharmaceutical Company, consultant to Wyeth and Boehringer Ingelheim and on the speakers' bureau for Merck. S.R.D. is a consultant to Abbott and Schering-Plough. B.B.K. and T.E.G. are inventors on patent applications related to RBP4.

PII: S0022-3476(08)00598-2

doi: 10.1016/j.jpeds.2008.07.018

The Journal of Pediatrics
Volume 154, Issue 1 , Pages 67-73.e1 , January 2009

Article Tools

* Image Usage & Resolution