The Journal of Pediatrics
Volume 154, Issue 1 , Pages 132-134 , January 2009

Significant Vitamin D Deficiency in Youth with Type 1 Diabetes Mellitus

  • Britta M. Svoren, MD

      Affiliations

    • Pediatric, Adolescent, and Young Adult Section, Genetics and Epidemiology Section, Joslin Diabetes Center, Boston, MA
    • Division of Endocrinology, Department of Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA
    • Corresponding Author InformationReprint requests: Britta Svoren, MD, Pediatric, Adolescent, and Young Adult Section, Joslin Diabetes Center, One Joslin Pl, Boston, MA 02215
    • ,
  • Lisa K. Volkening, MA

      Affiliations

    • Pediatric, Adolescent, and Young Adult Section, Genetics and Epidemiology Section, Joslin Diabetes Center, Boston, MA
    • ,
  • Jamie R. Wood, MD

      Affiliations

    • Pediatric, Adolescent, and Young Adult Section, Genetics and Epidemiology Section, Joslin Diabetes Center, Boston, MA
    • Division of Endocrinology, Department of Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA
    • ,
  • Lori M.B. Laffel, MD, MPH

      Affiliations

    • Pediatric, Adolescent, and Young Adult Section, Genetics and Epidemiology Section, Joslin Diabetes Center, Boston, MA
    • Division of Endocrinology, Department of Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA

Received 27 March 2008 ,Revised 6 May 2008 ,Accepted 14 July 2008.

References 

  1. Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc. 2006;81:353–373
  2. El Hajj FG, Nabulsi M, Choucair M, Salamoun M, Hajj SC, Kizirian A, et al. Hypovitaminosis D in healthy schoolchildren. Pediatrics. 2001;107:E53
  3. Tangpricha V, Pearce EN, Chen TC, Holick MF. Vitamin D insufficiency among free-living healthy young adults. Am J Med. 2002;112:659–662
  4. Tuominen JT, Impivaara O, Puukka P, Ronnemaa T. Bone mineral density in patients with type 1 and type 2 diabetes. Diabetes Care. 1999;22:1196–1200
  5. Miazgowski T, Czekalski S. A 2-year follow-up study on bone mineral density and markers of bone turnover in patients with long-standing insulin-dependent diabetes mellitus. Osteoporos Int. 1998;8:399–403
  6. Holmberg AH, Johnell O, Nilsson PM, Nilsson J, Berglund G, Akesson K. Risk factors for fragility fracture in middle age (A prospective population-based study of 33,000 men and women). Osteoporos Int. 2006;17:1065–1077
  7. Paul RG, Bailey AJ. Glycation of collagen: the basis of its central role in the late complications of ageing and diabetes. Int J Biochem Cell Biol. 1996;28:1297–1310
  8. Ward DT, Yau SK, Mee AP, Mawer EB, Miller CA, Garland HO, et al. Functional, molecular, and biochemical characterization of streptozotocin-induced diabetes. J Am Soc Nephrol. 2001;12:779–790
  9. Manolagas SC, Jilka RL. Bone marrow, cytokines, and bone remodeling (Emerging insights into the pathophysiology of osteoporosis). N Engl J Med. 1995;332:305–311
  10. McNair P, Christensen MS, Christiansen C, Madsbad S, Transbol I. Is diabetic osteoporosis due to microangiopathy?. Lancet. 1981;1:1271
  11. Schwartz AV. Diabetes mellitus: does it affect bone?. Calcif Tissue Int. 2003;73:515–519
  12. Pozzilli P, Manfrini S, Crino A, Picardi A, Leomanni C, Cherubini V, et al. Low levels of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 in patients with newly diagnosed type 1 diabetes. Horm Metab Res. 2005;37:680–683
  13. Littorin B, Blom P, Scholin A, Arnqvist HJ, Blohme G, Bolinder J, et al. Lower levels of plasma 25-hydroxyvitamin D among young adults at diagnosis of autoimmune type 1 diabetes compared with control subjects: results from the nationwide Diabetes Incidence Study in Sweden (DISS). Diabetologia. 2006;49:2847–2852
  14. Greer RM, Rogers MA, Bowling FG, Buntain HM, Harris M, Leong GM, et al. Australian children and adolescents with type 1 diabetes have low vitamin D levels. Med J Aust. 2007;187:59–60
  15. Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R. Estimates of optimal vitamin D status. Osteoporos Int. 2005;16:713–716
  16. Weng FL, Shults J, Leonard MB, Stallings VA, Zemel BS. Risk factors for low serum 25-hydroxyvitamin D concentrations in otherwise healthy children and adolescents. Am J Clin Nutr. 2007;86:150–158
  17. Bowman SA. Beverage choices of young females: changes and impact on nutrient intakes. J Am Diet Assoc. 2002;102:1234–1239
  18. Wyshak G. Teenaged girls, carbonated beverage consumption, and bone fractures. Arch Pediatr Adolesc Med. 2000;154:610–613

 Supported by grants from the National Institutes of Health (RO1DK046887 to L.L. and K12DK63696 to B.S.). Support was also received from the Charles H. Hood Foundation and Eli Lilly and Company. The authors declare no affiliations, financial agreements, or other involvements that would constitute a conflict of interest.

PII: S0022-3476(08)00597-0

doi: 10.1016/j.jpeds.2008.07.015

The Journal of Pediatrics
Volume 154, Issue 1 , Pages 132-134 , January 2009

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