The Journal of Pediatrics
Volume 154, Issue 2 , Pages 177-182.e2 , February 2009

Observational Study of Humidified High-Flow Nasal Cannula Compared with Nasal Continuous Positive Airway Pressure

  • Andrea L. Lampland, MD

      Affiliations

    • Infant Diagnostic & Research Center, Children's Hospitals and Clinics of Minnesota, St. Paul, MN
    • Corresponding Author InformationReprint requests: Andrea Lampland, MD, 347 N Smith Ave, Suite 505, St Paul, MN 55102
    • ,
  • Brenda Plumm

      Affiliations

    • Infant Diagnostic & Research Center, Children's Hospitals and Clinics of Minnesota, St. Paul, MN
    • ,
  • Patricia A. Meyers

      Affiliations

    • Infant Diagnostic & Research Center, Children's Hospitals and Clinics of Minnesota, St. Paul, MN
    • ,
  • Cathy T. Worwa

      Affiliations

    • Infant Diagnostic & Research Center, Children's Hospitals and Clinics of Minnesota, St. Paul, MN
    • ,
  • Mark C. Mammel, MD

      Affiliations

    • Infant Diagnostic & Research Center, Children's Hospitals and Clinics of Minnesota, St. Paul, MN
    • Department of Pediatrics, Division of Neonatology, University of Minnesota Medical School, Minneapolis, MN

Received 28 February 2008 ,Revised 25 April 2008 ,Accepted 11 July 2008.

References 

  1. Fanaroff A, Martin J. Neonatal-Perinatal Medicine. 7th ed. St Louis, MO: Mosby-Year Book; 2001;1003
  2. Jobe AH, Kramer BW, Moss TJ, Newnham JP, Ikegami M. Decreased indicators of lung injury with continuous positive expiratory pressure in preterm lambs. Pediatric Res. 2002;52:387–392
  3. Linder W, Vossbeck S, Hummler H, Pohlandt F. Delivery room management of extremely low birth weight infants: spontaneous breathing or intubation?. Pediatrics. 1999;103:961–967
  4. Gittermann MK, Fusch C, Gittermann AR, Regazzoni BM, Moessinger AC. Early nasal continuous positive airway pressure treatment reduces the need for intubation in very low birth weight infants. Eur J Pediatr. 1997;156:384–388
  5. Morley CJ, Davis PG, Doyle LW, Brion LP, Hascoet JM, Carlin JB. Nasal CPAP or intubation at birth for very preterm infants. N Engl J Med. 2008;358:700–708
  6. Locke RG, Wolfson MR, Shaffer TH, Rubenstein SD, Greenspan JS. Inadvertent administration of positive end-expiratory pressure during nasal cannula flow. Pediatrics. 1993;91:135–138
  7. Saslow JG, Aghai ZH, Nakhla TA, Hart JJ, Lawrysh R, Stahl GE, et al. Work of breathing using high-flow nasal cannula in preterm infants. J Perinatol. 2006;26:476–480
  8. Sreenan C, Lemke RP, Hudson-Mason A, Osiovich H. High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure. Pediatrics. 2001;107:1081–1083
  9. Spence KL, Murphy D, Kilian C, McGonigle R, Kilani RA. High-flow nasal cannula as a device to provide continuous positive airway pressure in infants. J Perinatol. 2007;27:772–775
  10. Seddon PC, Davis GM. Validity of esophageal pressure measurements with positive end-expiratory pressure in preterm infants. Pediatr Pulmonol. 2003;36:216–222
  11. Downes JJ, Vidyasagar D, Morrow GM, Boggs TR. Respiratory distress syndrome of newborn infants: new clinical scoring system (RDS score) with acid-base and blood gas correlations. Clin Pediatr. 1970;9:325–331
  12. Ramanathan A, Cayabyab R, Sardesai S, Siassi B, Istvan S, Ramanathan R. High-flow nasal cannula use in preterm and term newborns admitted to neonatal intensive care units: a prospective, observational study [abstract]. Pediatr Acad Soc. 2005;57:3417
  13. Chang GY, Cox CC, Shaffer TH. Nasal cannula, CPAP and Vapotherm: effect of flow on temperature, humidity, pressure and resistance [abstract]. Pediatr Acad Soc. 2005;57:1231
  14. Campbell DM, Shah PS, Shah V, Kelly EN. Nasal continuous positive airway pressure from high-flow cannula versus Infant Flow for preterm infants. J Perinatol. 2006;26:546–549
  15. Shoemaker MT, Pierce MR, Yoder BA, DiGeronimo RJ. High-flow nasal cannula versus nasal CPAP for neonatal respiratory disease: a retrospective study. J Perinatol. 2007;27:85–91
  16. Kubicka ZJ, Limauro J, Darnall RA. Heated, humidified high-flow nasal cannula therapy: yet another way to deliver continuous positive airway pressure?. Pediatrics. 2007;121:82–88
  17. Wilkinson DJ, Andersen CC, Smith K, Holberton J. Pharyngeal pressure with high-flow nasal cannulae in premature infants. J Perinatol. 2008;28:42–47
  18. Gappa M, Jackson E, Pilgrim L, Costeloe K, Stocks J. A new microtransducer catheter for measuring esophageal pressure in infants. Pediatr Pulmonol. 1996;22:117–124
  19. Pedersen JE, Nielsen K. Oropharyngeal and esophageal pressure during mono- and binasal CPAP in neonates. Acta Paediatr. 1994;83:143–149
  20. De Paoli AG, Lau R, Davis PG, Morley CJ. Pharyngeal pressure in preterm infants receiving nasal continuous positive airway pressure. Arch Dis Child Fetal Neonatal Ed. 2005;90:F79–F81

 Financial support for this study was provided by a grant from the Children's Hospitals and Clinics of Minnesota Foundation. The authors declare no conflicts of interest.

 This trial was registered at www.clinicaltrials.gov NCT00356668

PII: S0022-3476(08)00595-7

doi: 10.1016/j.jpeds.2008.07.021

The Journal of Pediatrics
Volume 154, Issue 2 , Pages 177-182.e2 , February 2009

Article Tools

* Image Usage & Resolution