The Journal of Pediatrics
Volume 154, Issue 1 , Pages 39-43.e3 , January 2009

Blood Cytokines during the Perinatal Period in Very Preterm Infants: Relationship of Inflammatory Response and Bronchopulmonary Dysplasia

  • Reija Paananen, PhD

      Affiliations

    • Department of Pediatrics, University of Oulu, Oulu, Finland
  • ,
  • Anna-Karin Husa, MSc

      Affiliations

    • Department of Pediatrics, University of Oulu, Oulu, Finland
  • ,
  • Reetta Vuolteenaho, PhD

      Affiliations

    • Department of Pediatrics, University of Oulu, Oulu, Finland
  • ,
  • Riitta Herva, MD, PhD

      Affiliations

    • Department of Pathology, University of Oulu, Oulu, Finland
  • ,
  • Tuula Kaukola, MD, PhD

      Affiliations

    • Department of Pediatrics, University of Oulu, Oulu, Finland
  • ,
  • Mikko Hallman, MD, PhD

      Affiliations

    • Department of Pediatrics, University of Oulu, Oulu, Finland
    • Corresponding Author InformationReprint requests: Mikko Hallman, MD, Children's Hospital, Oulu University Central Hospital, 90220 Oulu, Finland

Received 21 December 2007 ,Revised 5 June 2008 ,Accepted 8 July 2008.

References 

  1. Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2001;163:1723–1729
  2. Speer CP. Inflammation and bronchopulmonary dysplasia: a continuing story. Semin Fetal Neonatal Med. 2006;11:354–362
  3. Gomez R, Romero R, Ghezzi F, Yoon BH, Mazor M, Berry SM. The fetal inflammatory response syndrome. Am J Obstet Gynecol. 1981;179:194–202
  4. Watterberg KL, Demers LM, Scott SM, Murphy S. Chorioamnionitis and early lung inflammation in infants in whom bronchopulmonary dysplasia develops. Pediatrics. 1996;97:210–215
  5. Viscardi RM, Muhumuza CK, Rodriguez A, Fairchild KD, Sun CC, Gross GW, et al. Inflammatory markers in intrauterine and fetal blood and cerebrospinal fluid compartments are associated with adverse pulmonary and neurologic outcomes in preterm infants. Pediatr Res. 2004;55:1009–1017
  6. An H, Nishimaki S, Ohyama M, Haruki A, Naruto T, Kobayashi N, et al. Interleukin-6, interleukin-8, and soluble tumor necrosis factor receptor-I in the cord blood as predictors of chronic lung disease in premature infants. Am J Obstet Gynecol. 2004;19:1649–1654
  7. Merritt TA, Cochrane CG, Holcomb K, Bohl B, Hallman M, Strayer D, et al. Elastase and alpha 1-proteinase inhibitor activity in tracheal aspirates during respiratory distress syndrome: role of inflammation in the pathogenesis of bronchopulmonary dysplasia. J Clin Invest. 1983;72:656–666
  8. Groneck P, Götze-Speer B, Oppermann M, Eiffert H, Speer CP. Association of pulmonary inflammation and increased microvascular permeability during the development of bronchopulmonary dysplasia: a sequential analysis of inflammatory mediators in respiratory fluids of high-risk preterm neonates. Pediatrics. 1994;93:712–718
  9. Jones CA, Cayabyab RG, Kwong KY, Stotts C, Wong B, Hamdan H, et al. Undetectable interleukin (IL)-10 and persistent IL-8 expression early in hyaline membrane disease: a possible developmental basis for the predisposition to chronic lung inflammation in preterm newborns. Pediatr Res. 1996;39:966–975
  10. Bry K, Hallman M, Teramo K, Waffarn F, Lappalainen U. Granulocyte-macrophage colony-stimulating factor in amniotic fluid and in airway specimens of newborn infants. Pediatr Res. 1997;41:105–109
  11. Vento G, Capoluongo E, Matassa PG, Concolino P, Vendettuoli V, Vaccarella C, et al. Serum levels of seven cytokines in premature ventilated newborns: correlations with old and new forms of bronchopulmonary dysplasia. Intensive Care Med. 2006;32:723–730
  12. Romero R, Espinoza J, Chaiworapongsa T, Kalache K. Infection and prematurity and the role of preventive strategies. Semin Neonatol. 2002;7:259–274
  13. Bry K, Lappalainen U, Hallman M. Intra-amniotic interleukin-1 accelerates surfactant protein synthesis in fetal rabbits and improves lung stability after premature birth. J Clin Invest. 1997;99:2992–2999
  14. Jobe AH, Newnham JP, Willet KE, Sly P, Ervin MG, Bachurski C, et al. Effects of antenatal endotoxin and glucocorticoids on the lungs of preterm lambs. Am J Obstet Gynecol. 2000;182:401–408
  15. Moss TJ, Nitsos I, Kramer BW, Ikegami M, Newnham JP, Jobe AH. Intra-amniotic endotoxin induces lung maturation by direct effects on the developing respiratory tract in preterm sheep. Am J Obstet Gynecol. 2002;187:1059–1065
  16. Kallapur SG, Bachurski CJ, Le Cras TD, Joshi SN, Ikegami M, Jobe AH. Vascular changes after intra-amniotic endotoxin in preterm lamb lungs. Am J Physiol Lung Cell Mol Physiol. 2004;287:L1178–L1185
  17. Bry K, Whitsett JA, Lappalainen U. IL-1β disrupts postnatal lung morphogenesis in the mouse. Am J Respir Cell Mol Biol. 2007;36:32–42
  18. Vicencio AG, Lee CG, Cho SJ, Eickelberg O, Chuu Y, Haddad GG, et al. Conditional overexpression of bioactive transforming growth factor-beta1 in neonatal mouse lung: a new model for bronchopulmonary dysplasia?. Am J Respir Cell Mol Biol. 2004;31:650–656
  19. Coalson JJ. Pathology of bronchopulmonary dysplasia. Semin Perinatol. 2006;30:179–184
  20. Salafia CM, Weigl C, Silberman L. The prevalence and distribution of acute placental inflammation in uncomplicated term pregnancies. Obstet Gynecol. 1989;73:383–389
  21. Goldenberg RL, Andrews WW, Mercer BM, Moawad AH, Meis PJ, Iams JD, et al. The preterm prediction study: granulocyte colony-stimulating factor and spontaneous preterm birth (National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network). Am J Obstet Gynecol. 2000;182:625–630
  22. Kaukola T, Herva R, Perhomaa M, Pääkkö E, Kingsmore S, Vainionpää L, et al. Population cohort associating chorioamnionitis, cord inflammatory cytokines and neurologic outcome in very preterm, extremely low birth weight infants. Pediatr Res. 2006;59:478–483
  23. Yanowitz TD, Jordan JA, Gilmour CH, Towbin R, Bowen A, Roberts JM, et al. Hemodynamic disturbances in premature infants born after chorioamnionitis: association with cord blood cytokine concentrations. Pediatr Res. 2002;51:310–316
  24. Shimoya K, Matsuzaki N, Taniguchi T, Jo T, Saji F, Kitajima H, et al. Interleukin-8 in cord sera: a sensitive and specific marker for the detection of preterm chorioamnionitis. J Infect Dis. 1992;165:957–960
  25. Shimoya K, Taniguchi T, Matsuzaki N, Moriyama A, Murata Y, Kitajima H, et al. Chorioamnionitis decreased incidence of respiratory distress syndrome by elevating fetal interleukin-6 serum concentration. Hum Reprod. 2000;15:2234–2240
  26. Yoon BH, Romero R, Kim KS, Park JS, Ki SH, Kim BI, et al. A systemic fetal inflammatory response and the development of bronchopulmonary dysplasia. Am J Obstet Gynecol. 1999;181:773–779
  27. Van Marter LJ, Dammann O, Allred EN, Leviton A, Pagano M, Moore M, et al. Chorioamnionitis, mechanical ventilation, and postnatal sepsis as modulators of chronic lung disease in preterm infants. J Pediatr. 2002;140:171–176
  28. Watterberg KL, Scott SM, Backstrom C, Gifford KL, Cook KL. Links between early adrenal function and respiratory outcome in preterm infants: airway inflammation and patent ductus arteriosus. Pediatrics. 2000;105:320–324
  29. Kallapur SG, Jobe AH, Ball MK, Nitsos I, Moss TJ, Hillman NH, et al. Pulmonary and systemic endotoxin tolerance in preterm fetal sheep exposed to chorioamnionitis. J Immunol. 2007;179:8491–8499
  30. Beresford MW, Shaw NJ. Detectable IL-8 and IL-10 in bronchoalveolar lavage fluid from preterm infants ventilated for respiratory distress syndrome. Pediatr Res. 2002;52:973–978
  31. Jonsson B, Li YH, Noack G, Brauner A, Tullus K. Down-regulatory cytokines in tracheobronchial aspirate fluid from infants with chronic lung disease of prematurity. Acta Paediatr. 2000;89:1375–1380

 Supported by the Sigrid Jusélius Foundation, Foundation for Pediatric Research Finland, and Biocenter Oulu. The authors declare no potential conflicts of interest, real or perceived.

 Reija Paananen and Anna-Karin Husa contributed equally to this work.

PII: S0022-3476(08)00593-3

doi: 10.1016/j.jpeds.2008.07.012

The Journal of Pediatrics
Volume 154, Issue 1 , Pages 39-43.e3 , January 2009