The Journal of Pediatrics
Volume 154, Issue 1 , Pages 44-49 , January 2009

An Economic Analysis of Anemia Prevention during Infancy

  • Marcus Shaker, MD, MS

      Affiliations

    • Children's Hospital at Dartmouth, Lebanon, NH
    • The Center for the Evaluative Clinical Sciences, Hanover, NH
    • Corresponding Author InformationReprint requests: Marcus Shaker, MD, Dartmouth-Hitchcock Medical Center, Department of Pediatrics, One Medical Center Dr, Lebanon, NH 03756
    • ,
  • Pamela Jenkins, MD, PhD

      Affiliations

    • Children's Hospital at Dartmouth, Lebanon, NH
    • The Center for the Evaluative Clinical Sciences, Hanover, NH
    • ,
  • Christina Ullrich, MD, MPH

      Affiliations

    • Dana Farber Cancer Institute, Boston, MA
    • ,
  • Carlo Brugnara, MD

      Affiliations

    • Children's Hospital, Boston, MA
    • ,
  • Bao Tram Nghiem, BA

      Affiliations

    • Dartmouth College, Hanover, NH
    • ,
  • Henry Bernstein, DO

      Affiliations

    • Children's Hospital at Dartmouth, Lebanon, NH
    • Children's Hospital, Boston, MA

Received 11 December 2007 ,Revised 28 April 2008 ,Accepted 24 June 2008.

References 

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  2. Lozoff B, Brittenham GM, Viteri FE, Wolf AW, Urrutia JJ. Developmental deficits in iron-deficient infants: effects of age and severity of iron lack. J Pediatr. 1982;101:948–952
  3. Oski FA, Honig AS, Helu B, Howanitz P. Effect of iron therapy on behavior performance in nonanemic, iron-deficient infants. Pediatrics. 1983;71:877–880
  4. Walter T, Kovalskys J, Stekel A. Effect of mild iron deficiency on infant mental development scores. J Pediatr. 1983;102:519–522
  5. Halterman JS, Kaczorowski JM, Aligne CA, Auinger P, Szilagyi PG. Iron deficiency and cognitive achievement among school-aged children and adolescents in the United States. Pediatrics. 2001;107:1381–1386
  6. Lozoff B, Jimenez E, Wolf AW. Long-term developmental outcome of infants with iron deficiency. N Engl J Med. 1991;325:687–694
  7. Lozoff B, Jimenez E, Hagen J, Mollen E, Wolf AW. Poorer behavioral and developmental outcome more than 10 years after treatment for iron deficiency in infancy. Pediatrics. 2000;105:E51
  8. Walter T, De Andraca I, Chadud P, Perales CG. Iron deficiency anemia: adverse effects on infant psychomotor development. Pediatrics. 1989;84:7–17
  9. Lozoff B, De Andraca I, Castillo M, Smith JB, Walter T, Pino P. Behavioral and developmental effects of preventing iron-deficiency anemia in healthy full-term infants. Pediatrics. 2003;112:846–854
  10. Goodnough LT, Skikne B, Brugnara C. Erythropoietin, iron, and erythropoiesis. Blood. 2000;96:823–833
  11. Major A, Mathez-Loic F, Rohling R, Gautschi K, Brugnara C. The effect of intravenous iron on the reticulocyte response to recombinant human erythropoietin. Br J Haematol. 1997;98:292–294
  12. Brugnara C, Laufer MR, Friedman AJ, Bridges K, Platt O. Reticulocyte hemoglobin content (CHr): early indicator of iron deficiency and response to therapy. Blood. 1994;83:3100–3101
  13. Ullrich C, Wu A, Armsby C, Rieber S, Wingerter S, Brugnara C, et al. Screening healthy infants for iron deficiency using reticulocyte hemoglobin content. JAMA. 2005;294:924–930
  14. Hunink MG. Decision Making in Health and Medicine: integrating evidence and values. United Kingdom: University Press, Cambridge; 2004;
  15. Centers for Medicare and Medicaid Services. www.cms.hhs.govAccessed 1/28/2007
  16. Bureau of Labor Statistics. http://www.bls.gov/Last accessed 3/10/06
  17. Bogen DL, Krause JP, Serwint JR. Outcome of children identified as anemic by routine screening in an inner-city clinic. Arch Pediatr Adolesc Med. 2001;155:366–371
  18. Doctor's Office and Emergency Department Visits. http://www.dhmc.org/webpage.cfm?site_id=2&org_id=564&morg_id=0&sec_id=0&gsec_id=29698&item_id=29698Accessed 3/25/2008
  19. Biondich PG, Downs SM, Caroll AE, Laskey AL, Liu GC, Rosenman M, et al. Shortcoming in infant iron deficiency screening methods. Pediatrics. 2006;117:290–294
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  21. Prosser LA, Bridges CB, Uyeki TM, Rego VH, Ray GT, Meltzer MI, et al. Values for preventing influenza-related morbidity and vaccine adverse events in children. Health Qual Life Outcomes. 2005;3:18
  22. Ortega A, Dranitsaris G, Puodziunas AL. What are cancer patients willing to pay for prophylactic epoetin alfa? (A cost-benefit analysis). Cancer. 1998;83:2588–2596

 The authors have no conflicts of interest to declare.

PII: S0022-3476(08)00570-2

doi: 10.1016/j.jpeds.2008.06.038

The Journal of Pediatrics
Volume 154, Issue 1 , Pages 44-49 , January 2009

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