The Journal of Pediatrics
Volume 153, Issue 6 , Pages 799-802 , December 2008

Randomized, Comparative Efficacy Trial of Oral Penicillin Versus Cefuroxime for Perianal Streptococcal Dermatitis in Children

Received 26 February 2008 ,Revised 20 May 2008 ,Accepted 18 June 2008.

References 

  1. Kokx NP, Comstock JA, Facklam RR. Streptococcal perianal disease in children. Pediatrics. 1987;80:659–663
  2. Amren DP, Anderson AS, Wannamaker LW. Perianal cellulitis associated with group A streptococci. Am J Dis Child. 1966;112:546–552
  3. Landolt M, Heininger U. Prevalence of perianal streptococcal dermatitis in children and adolescents. Schweiz Rundsch Med Prax. 2005;94:1467–1471
  4. Mogielnicki NP, Schwartzman JD, Elliott JA. Perineal group A streptococcal disease in a pediatric practice. Pediatrics. 2000;106:276–281
  5. Morgenroth HHA. Perianale Streptokokkeninfektionen, eine mögliche Ursache für den Pruritus ani, perianale Dermatitis, Defäkationsschmerzen, Stuhl-verhalt und blutige Stuhlauflagerungen. Monatsschr Kinderheilkd. 1995;144:55–58
  6. Neri I, Bardazzi F, Marzaduri S, Patrizi A. Perianal streptococcal dermatitis in adults. Br J Dermatol. 1996;135:796–798
  7. Hirschfeld AJ. Two family outbreaks of perianal cellulitis associated with group A beta-hemolytic streptococci. Pediatrics. 1970;46:799–802
  8. Petersen JP, Kaltoft MS, Misfeldt JC, Schumacher H, Schonheyder HC. Community outbreak of perianal group A streptococcal infection in Denmark. Pediatr Infect Dis J. 2003;22:105–109
  9. McKee WM, Di Caprio JM, Roberts CE, Sherris JC. Anal carriage as the probable source of a streptococcal epidemic. Lancet. 1966;2:1007–1009
  10. Muotiala A, Saxen H, Vuopio-Varkila J. Group A streptococcal outbreak of perianal infection in a day-care centre. Adv Exp Med Biol. 1997;418:211–215
  11. Asnes RS, Vail D, Grebin B, Sprunt K. Anal carrier rate of group A beta-hemolytic streptococci in children with streptococcal pharyngitis. Pediatrics. 1973;52:439–441
  12. Kranke B, Trummer M, Brabek E, Komericki P, Turek TD, Aberer W. Etiologic and causative factors in perianal dermatitis: results of a prospective study in 126 patients. Wien Klin Wochenschr. 2006;118:90–94
  13. Guppy DH. Perianal group A streptococcal infection. J Paediatr Child Health. 1993;29:144–145
  14. Heidelberger A, Cremer H, Ring J, Abeck D. Perianal streptococcal dermatitis. Hautarzt. 2000;51:86–89
  15. Honig PJ. Guttate psoriasis associated with perianal streptococcal disease. J Pediatr. 1988;113:1037–1039
  16. Rehder PA, Eliezer ET, Lane AT. Perianal cellulitis (Cutaneous group A streptococcal disease). Arch Dermatol. 1988;124:702–704
  17. Wright JE, Butt HL. Perianal infection with beta haemolytic streptococcus. Arch Dis Child. 1994;70:145–146
  18. Lainka EBA. Streptokokkeninfektion als Ursache für eine chronische perianale Dermatitis bei Kindern. Monatsschr Kinderheilkd. 2002;150:981–984
  19. Herbst R. Perineal streptococcal dermatitis/disease: recognition and management. Am J Clin Dermatol. 2003;4:555–560
  20. Adam D, Scholz H, Helmerking M. Comparison of short-course (5 day) cefuroxime axetil with a standard 10 day oral penicillin V regimen in the treatment of tonsillopharyngitis. J Antimicrob Chemother. 2000;45(Suppl):23–30
  21. Nelson JD. Cefuroxime: a cephalosporin with unique applicability to pediatric practice. Pediatr Infect Dis. 1983;2:394–396
  22. Wise R. Clinical efficacy and antimicrobial pharmacodynamics. Hosp Med. 2000;61:24–30
  23. Schaad UB. Acute streptococcal tonsillopharyngitis: a review of clinical efficacy and bacteriological eradication. J Internat Med Res. 2004;32:1–13

 The authors declare no potential conflicts of interest.

 Clinical Trial Register number: NCT00261742.

PII: S0022-3476(08)00528-3

doi: 10.1016/j.jpeds.2008.06.035

The Journal of Pediatrics
Volume 153, Issue 6 , Pages 799-802 , December 2008

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