The Journal of Pediatrics
Volume 153, Issue 6 , Pages 790-794 , December 2008

Hypotension in Preterm Infants with Significant Patent Ductus Arteriosus: Effects of Dopamine

  • Antoine Bouissou, MD

      Affiliations

    • Department of Perinatal Medicine, Hôpital Jeanne de Flandre, CHRU Lille, France
    • Corresponding Author InformationReprint requests: Antoine Bouissou, MD, Department of Perinatal Medicine Hopital Jeanne de Flandre, CHRU de Lille, Lille cedex 59037, France
    • ,
  • Thameur Rakza, MD

      Affiliations

    • Department of Perinatal Medicine, Hôpital Jeanne de Flandre, CHRU Lille, France
    • UPRES-JE2490, Faculté de Médecine, Université de Lille II, Lille, France
    • ,
  • Serge Klosowski, MD

      Affiliations

    • Department of Perinatal Medicine, Hôpital Jeanne de Flandre, CHRU Lille, France
    • ,
  • Pierre Tourneux, MD

      Affiliations

    • PériTox (EA 3901-INERIS), Faculté de Médecine, UPJV, Amiens, France
    • Réanimation Néonatale, CHU Amiens, France
    • ,
  • Marie Vanderborght, MD

      Affiliations

    • Department of Perinatal Medicine, Hôpital Jeanne de Flandre, CHRU Lille, France
    • ,
  • Laurent Storme, MD, PhD

      Affiliations

    • Department of Perinatal Medicine, Hôpital Jeanne de Flandre, CHRU Lille, France
    • UPRES-JE2490, Faculté de Médecine, Université de Lille II, Lille, France

Received 2 January 2008 ,Revised 8 May 2008 ,Accepted 17 June 2008.

References 

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  2. Knight DB. The treatment of patent ductus arteriosus in preterm infants (A review and overview of randomized trials). Semin Neonatol. 2001;6:63–73
  3. Rakza T, Magnenant E, Klosowski S, Tourneux P, Bachiri A, Storme L. Early hemodynamic consequences of patent ductus arteriosus in preterm infants with intra-uterine growth restriction. J Pediatr. 2007;151:624–628
  4. Evans N, Moorcraft J. Effect of patency of the ductus arteriosus on blood pressure in very preterm infants. Arch Dis Child. 1992;67:1169–1173
  5. Kluckow M, Evans N. Ductal shunting, high pulmonary blood flow, and pulmonary hemorrhage. J Pediatr. 2000;137:68–72
  6. Shortland DB, Gibson NA, Levene MI, Archer LN, Evans DH, Shaw DE. Patent ductus arteriosus and cerebral circulation in preterm infants. Dev Med Child Neurol. 1990;32:386–393
  7. Shimada S, Kasai T, Konishi M, Fujiwara T. Effects of patent ductus arteriosus on left ventricular output and organ blood flows in preterm infants with respiratory distress syndrome treated with surfactant. J Pediatr. 1994;125:270–277
  8. El Hajjar M, Vaksmann G, Rakza T, Kongolo G, Storme L. Severity of the ductal shunt: a comparison of different markers. Arch Dis Child Fetal Neonatal Ed. 2005;90:F419–F422
  9. Hermes-DeSantis ER, Clyman RI. Patent ductus arteriosus: pathophysiology and management. J Perinat. 2006;26:S14–S18
  10. Seri I, Noori S. Diagnosis and treatment of neonatal hypotension outside the transitional period. Early Hum Dev. 2005;81:405–411
  11. Subhedar NV, Shaw NJ. Dopamine versus dobutamine for hypotensive preterm infants. Cochrane Database Syst Rev. 2000;CD001242
  12. Seri I. Cardiovascular, renal and endocrine actions of dopamine in neonates and children. J Pediatr. 1995;126:333–344
  13. Rozé JC, Tohier C, Maingueneau C, Lefèvre M, Mouzard A. Response to dobutamine and dopamine in the hypotensive very preterm infant. Arch Dis Child. 1993;69:59–63
  14. Jaillard S, Houfflin-Debarge V, Riou Y, Rakza T, Klosowski S, Lequien P, et al. Effects of catecholamines on the pulmonary circulation in the ovine fetus. Am J Physiol Regul Integr Comp Physiol. 2001;281:R607–R614
  15. Liet JM, Boscher C, Gras-Leguen C, Gournay V, Debillon T, Rozé JC. Dopamine effects on pulmonary artery pressure in hypotensive preterm infants with patent ductus arteriosus. J Pediatr. 2002;140:373–375
  16. Pejovic B, Peco-Antic A, Marinkovic-Eric J. Blood pressure in non-critically ill preterm and full-term neonates. Pediatr Nephrol. 2007;22:249–257
  17. Engle WD. Blood pressure in the very low birth weight neonates. Early Hum Dev. 2001;62:97–130
  18. Kluckow M, Evans N. Superior vena cava flow in newborn infants: a novel marker of systemic blood flow. Arch Dis Child Fetal Neonatal Ed. 2000;82:F182–F187
  19. Musewe NN, Poppe D, Smallhorn JF, Hellman J, Whyte H, Smith B, et al. Doppler echocardiographic measurement of pulmonary artery pressure from ductal Doppler velocities in the newborn. J Am Coll Cardiol. 1990;15:446–456
  20. Skinner JR, Boys RJ, Heads A, Hey EN, Hunter S. Estimation of pulmonary arterial pressure in the newborn: study of the repeatability of four Doppler echocardiographic techniques. Pediatr Cardiol. 1996;17:360–369
  21. Sakamoto H, Takenoshita M, Asakura Y, Ibara S, Ikenoue T. Comparison of circulatory effects between arginine vasopressin (AVP) and dopamine in conscious newborn goats. J Vet Med Sci. 1996;58:511–514
  22. Mentzer RM, Alegre CA, Nolan SP. The effects of dopamine and isoproterenol on the pulmonary circulation. J Thorac Cardiovasc Surg. 1976;71:807–814
  23. Marx GR, Allen HD, Goldberg SJ. Doppler echocardiographic estimation of systolic pulmonary artery pressure in patients with aortic-pulmonary shunts. J Am Coll Cardiol. 1986;4:880–885
  24. Groves AM, Kuschel CA, Knight DB, Skinner JR. Does retrograde diastolic flow in the descending aorta signify impaired systemic perfusion in preterm infants?. Pediatr Res. 2008;63:89–94
  25. Osborn DA, Evans N, Kluckow M. Left ventricular contractility in extremely premature infants in the first day and response to inotropes. Pediatr Res. 2007;61:335–340

 The authors declare no conflicts of interest.

PII: S0022-3476(08)00514-3

doi: 10.1016/j.jpeds.2008.06.014

The Journal of Pediatrics
Volume 153, Issue 6 , Pages 790-794 , December 2008

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