The Journal of Pediatrics
Volume 153, Issue 5 , Pages 596-598 , November 2008

Domperidone-Induced QT Prolongation: Add Another Drug to the List

  • Kathryn K. Collins, MD

      Affiliations

    • University of Colorado Denver, The Children's Hospital, Denver, Colorado
    • Corresponding Author InformationReprint requests: Kathryn K. Collins, MD, The Children's Hospital, Department of Cardiology/B100, 13123 E 16th Ave, Aurora, CO 80045
    • ,
  • Judith M. Sondheimer, MD

      Affiliations

    • Professor Emeritus, University of Colorado, Denver, Colorado

References 

  1. Kannankeril PJ. Understanding drug-induced torsades de pointes: a genetic stance. Expert Opin Drug Saf. 2008;7:231–239
  2. Gupta A, Lawrence AT, Krishnan K, Kavinsky CJ, Trohman RG. Current concepts in the mechanisms and management of drug-induced QT prolongation and torsade de pointes. Am Heart J. 2007;153:891–899
  3. Zeltser D, Justo D, Halkin A, Prokhorov V, Heller K, Viskin S. Torsade de pointes due to noncardiac drugs: most patients have easily identifiable risk factors. Medicine (Baltimore). 2003;82:282–290
  4. Djeddi D, Kongolo G, Lefaix C, Moundard J, Leke A. Effect of domperidone on QT interval in neonates. J Pediatr. 2008;153:663–666
  5. Drolet B, Rousseau G, Daleau P, Cardinal R, Turgeon J. Domperidone should not be considered a no-risk alternative to cisapride in the treatment of gastrointestinal motility disorders. Circulation. 2000;102:1883–1885
  6. Rocha CM, Barbosa MM. QT interval prolongation associated with the oral use of domperidone in an infant. Pediatr Cardiol. 2005;26:720–723
  7. Wysowski DK, Corken A, Gallo-Torres H, Talarico L, Rodriguez EM. Postmarketing reports of QT prolongation and ventricular arrhythmia in association with cisapride and Food and Drug Administration regulatory actions. Am J Gastroenterol. 2001;96:1698–1703
  8. Hill SL, Evangelista JK, Pizzi AM, Mobassaleh M, Fulton DR, Berul CI. Proarrhythmia associated with cisapride in children. Pediatrics. 1998;101:1053–1056
  9. Khongphatthanayothin A, Lane J, Thomas D, Yen L, Chang D, Bubolz B. Effects of cisapride on QT interval in children. J Pediatr. 1998;133:51–56
  10. Bruera E, Villamayor R, Roca E, Barugel M, Tronge J, Chacon R. Q-T interval prolongation and ventricular fibrillation with IV domperidone. Cancer Treat Rep. 1986;70:545–546
  11. Giaccone G, Bertetto O, Calciati A. Two sudden deaths during prophylactic antiemetic treatment with high doses of domperidone and methylprednisolone. Lancet. 1984;2(8415):1336–1337
  12. Vetter VL, Elia J, Erickson C, Berger S, Blum N, Uzark K, et al. Cardiovascular monitoring of children and adolescents with heart disease receiving stimulant drugs: a scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young Congenital Cardiac Defects Committee and the Council on Cardiovascular Nursing. Circulation. 2008;117:2407–2423
  13. Chan A, Isbister GK, Kirkpatrick CM, Dufful SB. Drug-induced QT prolongation and torsades de pointes: evaluation of a QT nomogram. QJM. 2007;100:609–615
  14. Augood C, MacLennan S, Gilbert R, Logan S. Cisapride treatment for gastro-oesophageal reflux in children. Cochrane Database Syst Rev. 2003;(4):CD002300
  15. Craig WR, Hanlon-Dearman A, Sinclair C, Taback S, Moffatt M. Metoclopramide, thickened feedings, and positioning for gastro-oesophageal reflux in children under two years. Cochrane Database Syst Rev. 2004;(4):CD003502
  16. Dalby-Payne JR, Morris AM, Craig JC. Meta-analysis of randomized controlled trials on the benefits and risks of using cisapride for the treatment of gastroesophageal reflux in children. J Gastroenterol Hepatol. 2003;18:196–202
  17. Pritchard DS, Baber N, Stephenson T. Should domperidone be used for the treatment of gastro-oesophageal reflux in children? (Systematic review of randomized controlled trials in children aged 1 month to 11 years old). Br J Clin Pharmacol. 2005;59:725–729
  18. Shafrir Y, Levy Y, Ben-Amitai D, Nitzan M, Steinherz R. Oculogyric crisis due to domperidone therapy. Helv Paediatr Acta. 1985;40:95

PII: S0022-3476(08)00504-0

doi: 10.1016/j.jpeds.2008.06.009

The Journal of Pediatrics
Volume 153, Issue 5 , Pages 596-598 , November 2008

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