The Journal of Pediatrics
Volume 153, Issue 5 , Pages 594-596 , November 2008

When There is Smoke, There May be Fire: Functional Abdominal Pain and the Role of Inflammation

  • Nader N. Youssef, MD

      Affiliations

    • Corresponding Author InformationReprint requests: Nader N. Youssef, MD, Center for Pediatric Irritable Bowel & Motility Disorders, Division of Pediatric Gastroenterology, Goryeb Children's Hospital at Atlantic Health, Morristown, NJ 07962
    • ,
  • Maria E. Perez, DO

References 

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  2. Gwee KA, Collins SM, Read SW. Increased rectal mucosal expression of interleukin 1 beta in recently acquired post infectious irritable bowel syndrome. Gut. 2003;52:523–526
  3. Shulman RJ, Eakin MN, Czyzewski DI, Jarrett M, Ou CN. Increased gastrointestinal permeability and gut inflammation in children with functional abdominal pain and irritable bowel syndrome. J Pediatr. 2008;153:646–650
  4. Drossman D, Corazziari E, Thompson WG, Talley NJ, Whitehead WE, editors. Clinical Diagnostic Questionnaire for Pediatric Functional Gastrointestinal Disorders. Rome II The Functional Gastrointestinal Disorders 2000. p. 715-22.
  5. Tibble J, Teahon K, Thjodleifsson B, Roseth A, Sigthorsson G, Bridger S, et al. A simple method for assessing intestinal inflammation in Crohn's disease. Gut. 2000;47:506–513
  6. Meling TR, Aabakken L, Roseth A, Osnes M. Fecal calprotectin shedding after short term treatment with non-steroidal anti-inflammatory drugs. Scand J Gastroenterol. 1996;31:339–344
  7. Tibble JA, Sigthorsson G, Foster R, Scott D, Fagerhol MK, Roseth A, et al. High prevalence of NSAID enteropathy as shown by a simple fecal test. Gut. 1999;45:362–366
  8. Somasundaram S, Hayllar H, Rafi S, Wrigglesworth JM, MacPherson AJS, Bjarnason I. The biochemical basis of non-steroidal anti-inflammatory drug-induced damage to the gastrointestinal tract: a review and a hypothesis. Scand J Gastroenterol. 1995;30:289–299
  9. Khalif IL, Quigley EMM, Konovitch EA, Maximova ID. Alterations in the colonic flora and intestinal permeability and evidence of immune activation in chronic constipation. Digestive and Liver Disease. 2005;35:839–848
  10. Fegerberg UL, Loof L, Lindholm J, Hansson LO, Finkel Y. Fecal calprotectin: a quantitative marker of colonic inflammation in children with inflammatory bowel disease. J Pedaitr Gastroenterol. 2005;40:450–455
  11. Carroccio A, Iacono G, Cottone M, DiParma L, Cartabellotta F, Cavataio F, et al. Diagnostic accuracy of fecal calprotectin assay in distinguishing organic causes of chronic diarrhea from irritable bowel syndrome: a prospective study in adults and children. Clinical Chemistry. 2003;49:861–867

PII: S0022-3476(08)00496-4

doi: 10.1016/j.jpeds.2008.06.001

The Journal of Pediatrics
Volume 153, Issue 5 , Pages 594-596 , November 2008

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