The Journal of Pediatrics
Volume 153, Issue 4 , Pages 541-546.e1 , October 2008

Correlation of Clinical and Biochemical Findings with Diabetic Ketoacidosis–Related Cerebral Edema in Children Using Magnetic Resonance Diffusion-Weighted Imaging

  • Nicole S. Glaser, MD

      Affiliations

    • Department of Pediatrics, University of California, Davis School of Medicine, Sacramento, CA
    • Corresponding Author InformationReprint requests: Nicole Glaser, MD, Department of Pediatrics, University of California Davis, School of Medicine, 2516 Stockton Blvd, Sacramento, CA 95817
    • ,
  • James P. Marcin, MD, MPH

      Affiliations

    • Department of Pediatrics, University of California, Davis School of Medicine, Sacramento, CA
    • ,
  • Sandra L. Wootton-Gorges, MD

      Affiliations

    • Department of Radiology, University of California, Davis School of Medicine, Sacramento, CA
    • ,
  • Michael H. Buonocore, MD, PhD

      Affiliations

    • Department of Radiology, University of California, Davis School of Medicine, Sacramento, CA
    • ,
  • Arleta Rewers, MD, PhD

      Affiliations

    • Department of Pediatrics, University of Colorado, School of Medicine, Denver, CO
    • ,
  • John Strain, MD

      Affiliations

    • Department of Radiology, University of Colorado, School of Medicine, Denver, CO
    • ,
  • Joseph DiCarlo, MD

      Affiliations

    • Department of Pediatrics, Stanford University School of Medicine, Sacramento, CA
    • ,
  • E. Kirk Neely, MD

      Affiliations

    • Department of Pediatrics, Stanford University School of Medicine, Sacramento, CA
    • ,
  • Patrick Barnes, MD

      Affiliations

    • Department of Emergency Medicine, University of California, Davis School of Medicine, Sacramento, CA
    • Department of Radiology, Stanford University School of Medicine, Sacramento, CA
    • ,
  • Nathan Kuppermann, MD, MPH

      Affiliations

    • Department of Pediatrics, University of California, Davis School of Medicine, Sacramento, CA
    • Department of Emergency Medicine, University of California, Davis School of Medicine, Sacramento, CA

Received 6 December 2007 ,Revised 18 March 2008 ,Accepted 14 April 2008.

References 

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  2. Edge J, Hawkins M, Winter D, Dunger D. The risk and outcome of cerebral oedema developing during diabetic ketoacidosis. Arch Dis Child. 2001;85:16–22
  3. Glaser N, Barnett P, McCaslin I, Nelson D, Trainor J, Louie J, et al. Risk factors for cerebral edema in children with diabetic ketoacidosis. N Engl J Med. 2001;344:264–269
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  11. Edge J, Jakes R, Roy Y, Hawkins M, Winter D, Ford-Adams M, et al. The UK case-control study of cerebral oedema complicating diabetic ketoacidosis in children. Diabetologia. 2006;49:2002–2009
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  23. Krane E, Rockoff M, Wallman J, Wolfsdorf J. Subclinical brain swelling in children during treatment of diabetic ketoacidosis. N Engl J Med. 1985;312:1147–1151
  24. Glaser N, Wooton-Gorges S, Buonocore M, Marcin J, Rewers A, Strain J, et al. Frequency of Sub-Clinical Cerebral Edema in Children with Diabetic Ketoacidosis. Pediatr Diab. 2006;7:75–80
  25. Wooton-Gorges S, Buonocore M, Kuppermann N, Marcin J, Barnes P, Neely E, et al. Cerebral proton magnetic resonance spectroscopy in children with diabetic ketoacidosis. Am J Neuroradiol. 2007;28:895–899
  26. Salem M, Matta L, Tantawy A, Husein M, Gad G. Single photon emission tomography (SPECT) study of regional cerebral blood flow in normoalbuminuric children and adolescents with type 1 diabetes. Pediatr Diab. 2002;3:155–162

 Supported by research awards from the American Diabetes Association and the University of California, Davis Health System. The study sponsors played no role in the design or conduct of the study, data collection, analysis or interpretation, nor in the preparation, review, or approval of the manuscript.

 The authors declared no potential conflict of interest.

PII: S0022-3476(08)00315-6

doi: 10.1016/j.jpeds.2008.04.048

The Journal of Pediatrics
Volume 153, Issue 4 , Pages 541-546.e1 , October 2008

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