The Journal of Pediatrics
Volume 153, Issue 2 , Pages 283-286.e1 , August 2008

A 6-Year-Old Child with Fever of Unknown Origin, Anemia, and Abdominal Pain

  • Andrew Zeft, MD

      Affiliations

    • Department of Pediatrics, Division of Immunology and Rheumatology, University of Utah, Salt Lake City, UT
    • Corresponding Author InformationReprint requests: Andrew Zeft, MD, Department of Pediatrics, Division of Immunology and Rheumatology, University of Utah, PO Box 581289, Salt Lake City, UT 84158.
    • ,
  • Hassan Yaish, MD

      Affiliations

    • Department of Pediatrics, Division of Hematology-Oncology, University of Utah, Salt Lake City, UT
    • ,
  • Jeffrey Prince, MD

      Affiliations

    • Department of Radiology, Division of Pediatric Radiology, University of Utah, Salt Lake City, UT.
    • ,
  • John Bohnsack, MD

      Affiliations

    • Department of Pediatrics, Division of Immunology and Rheumatology, University of Utah, Salt Lake City, UT
    • ,
  • W. Daniel Jackson, MD

      Affiliations

    • Department of Pediatrics, Division of Gastroenterology, University of Utah, Salt Lake City, UT
    • ,
  • Cheryl M. Coffin, MD

      Affiliations

    • Department of Pediatrics, Division of Pediatric Pathology, University of Utah, Salt Lake City, UT

Received 27 September 2007 ,Revised 11 March 2008 ,Accepted 3 April 2008.

References 

  1. Lowichik A, Jackson W, Coffin CM. Gastrointestinal polyposis in childhood: clinicopathologic and genetic features. Pediatr Dev Pathol. 2003;6:371–391
  2. Graeme-Cook MB, Lauwers G. Pediatric Gastrointestinal Disease: Pathophysiology, Diagnosis, Management. 4th edition. Hamilton, ON, Canada: BC Decker; 2004;
  3. Thompson WM, Kende AI, Levy AD. Imaging characteristics of gastric lipomas in 16 adult and pediatric patients. AJR Am J Roentgenol. 2003;181:981–985
  4. Estêvão-Costa J, Correia-Pinto J, Rodrigues FC, Carvalho JL, Campos M, Dias JA, et al. Gastric inflammatory myofibroblastic proliferation in children. Pediatr Surg Int. 1998;13:95–99
  5. Lazure T, Ferlicot S, Gauthier F, Doz F, Couturier J, Fabre M, et al. Gastric inflammatory myofibroblastic tumors in children: an unpredictable course. J Pediatr Gastroenterol Nutr. 2002;34:319–322
  6. Cho MY, Min YK, Kim NR, Cho SJ, Kim HK, Lee KC, et al. Fever of unknown origin as a presentation of gastric inflammatory myofibroblastic tumor in a two-year-old boy. J Korean Med Sci. 2002;17:699–703
  7. Coffin CM, Fletcher JA. Inflammatory myofibroblastic tumor. In:  Fletcher CDM,  Unni KK,  Mertens F editor. WHO Health Organization Classification of Tumors: Pathology and Genetics of Tumors of Soft Tissue and Bone. Lyon, France: IARC Press; 2002;p. 91–93
  8. Coffin C, Hornick J, Fletcher C. Inflammatory myofibroblastic tumor: comparison of clinicopathologic, histologic, and immunohistochemical features including ALK expression in atypical and aggressive cases. Am J Surg Pathol. 2007;31:509–520
  9. Coffin CM, Watterson J, Priest JR, Dehner LP. Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor): a clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol. 1995;19:859–872
  10. Mergan F, Jaubert F, Sauvat F, Hartmann O, Lortat-Jacob S, Révillon Y, et al. Inflammatory myofibroblastic tumor in children: clinical review with anaplastic lymphoma kinase, Epstein-Barr virus, and human herpesvirus-8 detection analysis. J Pediatr Surg. 2005;40:1581–1586
  11. Gomez-Roman JJ, Ocejo-Vinyals G, Sanchez-Velasco P, Nieto EH, Leyva-Cobian F, Val-Bernal JF. Presence of human herpesvirus-8 DNA sequences and overexpression of human IL-6 and cyclin D1 in inflammatory myofibroblastic tumor (inflammatory pseudotumor). Lab Invest. 2000;80:1121–1126
  12. Germanidis G, Xanthakis I, Tsitouridis I, Zaramboukas T, Kiskinis D, Konstantaras C, et al. Regression of inflammatory myofibroblastic tumor of the gastrointestinal tract under infliximab treatment. Dig Dis Sci. 2005;50:262–265
  13. Carrasco R, Smith JA, Lovell D. Biologic agents for the treatment of juvenile rheumatoid arthritis: current status. Paediatr Drugs. 2004;6:137–146
  14. Kim KA, Park CM, Lee JH, Cha SH, Park SW, Hong SJ, et al. Inflammatory myofibroblastic tumor of the stomach with peritoneal dissemination in a young adult: imaging findings. Abdom Imag. 2004;29:9–11
  15. Taratuta E, Krinsky G, Genega E, Roche K, Geneisier N. Pediatric inflammatory pseudotumor of the stomach: contrast-enhanced CT and MR imaging findings. AJR Am J Roentgenol. 1996;167:919–920
  16. Yesildag E, Sarimurat N, Ince U, Numan F, Buyukunal C. Nonsurgical diagnosis and management of an inflammatory pseudotumor of the spleen in a child. J Clin Ultrasound. 2003;31:335–338
  17. Hussong JW, Brown M, Perkins SL, Dehner LP, Coffin CM. Comparison of DNA ploidy, histologic, and immunohistochemical findings with clinical outcome in inflammatory myofibroblastic tumors. Mod Pathol. 1999;12:279–286

 None of the authors listed above have conflicts of interest with the contents of this manuscript.

PII: S0022-3476(08)00285-0

doi: 10.1016/j.jpeds.2008.04.020

The Journal of Pediatrics
Volume 153, Issue 2 , Pages 283-286.e1 , August 2008

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