A 6-Year-Old Child with Fever of Unknown Origin, Anemia, and Abdominal Pain

Zeft, Andrew; Yaish, Hassan; Prince, Jeffrey; Bohnsack, John; Jackson, W. Daniel; Coffin, Cheryl M.

doi:10.1016/j.jpeds.2008.04.020

« Previous Next »The Journal of Pediatrics
Volume 153, Issue 2 , Pages 283-286.e1, August 2008

A 6-Year-Old Child with Fever of Unknown Origin, Anemia, and Abdominal Pain

Andrew Zeft, MD
- Department of Pediatrics, Division of Immunology and Rheumatology, University of Utah, Salt Lake City, UT
- Reprint requests: Andrew Zeft, MD, Department of Pediatrics, Division of Immunology and Rheumatology, University of Utah, PO Box 581289, Salt Lake City, UT 84158.
Hassan Yaish, MD
- Department of Pediatrics, Division of Hematology-Oncology, University of Utah, Salt Lake City, UT
Jeffrey Prince, MD
- Department of Radiology, Division of Pediatric Radiology, University of Utah, Salt Lake City, UT.
John Bohnsack, MD
- Department of Pediatrics, Division of Immunology and Rheumatology, University of Utah, Salt Lake City, UT
W. Daniel Jackson, MD
- Department of Pediatrics, Division of Gastroenterology, University of Utah, Salt Lake City, UT
Cheryl M. Coffin, MD
- Department of Pediatrics, Division of Pediatric Pathology, University of Utah, Salt Lake City, UT

Received 27 September 2007; received in revised form 11 March 2008; accepted 3 April 2008.

The patient is a previously healthy 6-year-old Caucasian girl with a 1-month history of fever, anemia, diminished appetite, and a 3-pound weight loss. She had received courses of trimethaprim-sulfamethoxazole and amoxicillin for suspected sinusitis and lower urinary tract infections. Despite this treatment, fever up to 104°F persisted, occurring primarily in the evenings. Although there were no identifiable preceding human sick contacts, her dog had died from canine parvovirus infection 1 month before the onset of her symptoms.

Abbreviations: ALK, Anaplastic lymphoma kinase, CT, Computed tomography, HHV, Human herpesvirus, IL, Interleukin, IMT, Inflammatory myofibroblastic tumor, MRA, Magnetic resonance angiography, MRI, Magnetic resonance imaging, PCR, Polymerase chain reaction