The Journal of Pediatrics
Volume 153, Issue 3 , Pages 429-431 , September 2008

Recurrence of Cardiorespiratory Events following Repeat DTaP-Based Combined Immunization in Very Low Birth Weight Premature Infants

Received 29 December 2007 ,Revised 12 February 2008 ,Accepted 26 March 2008.

References 

  1. Omenaca F, Garcia-Sicilia J, Garcia-Corbeira P, Boceta R, Romero A, Lopez G, et al. Response of preterm newborns to immunization with a hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B virus–inactivated polio and Haemophilus influenzae type b vaccine: first experiences and solutions to a serious and sensitive issue. Pediatrics. 2005;116:1292–1298
  2. Pourcyrous M, Korones SB, Arheart KL, Bada HS. Primary immunization of premature infants with gestational age <35 weeks: cardiorespiratory complications and C-reactive protein responses associated with administration of single and multiple separate vaccines simultaneously. J Pediatr. 2007;151:167–172
  3. Lee J, Robinson JL, Spady DW. Frequency of apnea, bradycardia, and desaturations following first diphtheria-tetanus-pertussis–inactivated polio-Haemophilus influenzae type B immunization in hospitalized preterm infants. BMC Pediatr. 2006;6:20
  4. Schulzke S, Heininger U, Lucking-Famira M, Fahnenstich H. Apnoea and bradycardia in preterm infants following immunisation with pentavalent or hexavalent vaccines. Eur J Pediatr. 2005;164:432–435
  5. Pfister RE, Aeschbach V, Niksic-Stuber V, Martin BC, Siegrist CA. Safety of DTaP-based combined immunization in very-low-birth-weight premature infants: frequent but mostly benign cardiorespiratory events. J Pediatr. 2004;145:58–66
  6. Office Fédéral de la Santé Publique. Plan de Vaccination Suisse 2007 (Directives et Recommendations 8). http://www.infovac.ch/index.php?Itemid=55&option=com_contentAccessed December 20, 2007
  7. Ellison VJ, Davis PG, Doyle LW. Adverse reactions to immunization with newer vaccines in the very preterm infant. J Paediatr Child Health. 2005;41:441–443
  8. D'Angio CT. Active immunization of premature and low birth-weight infants: a review of immunogenicity, efficacy, and tolerability. Paediatr Drugs. 2007;9:17–32
  9. Pourcyrous M, Korones SB, Crouse D, Bada HS. Interleukin-6, C-reactive protein, and abnormal cardiorespiratory responses to immunization in premature infants. Pediatrics. 1998;101:e3
  10. Cohen G, Lagercrantz H, Katz-Salamon M. Abnormal circulatory stress responses of preterm graduates. Pediatr Res. 2007;61:329–334
  11. Faldella G, Galletti S, Corvaglia L, Ancora G, Alessandroni R. Safety of DTaP-IPV-HIb-HBV hexavalent vaccine in very premature infants. Vaccine. 2007;25:1036–1042

 C.S. has received research grants and honoraria for her participation in scientific advisory boards of numerous vaccine companies, but none related to this work.

 No reprints are available from the authors.

PII: S0022-3476(08)00270-9

doi: 10.1016/j.jpeds.2008.03.043

The Journal of Pediatrics
Volume 153, Issue 3 , Pages 429-431 , September 2008

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