The Journal of Pediatrics
Volume 153, Issue 3 , Pages 375-378.e2 , September 2008

Association between Urinary Lactate to Creatinine Ratio and Neurodevelopmental Outcome in Term Infants with Hypoxic-Ischemic Encephalopathy

  • William Oh, MD

      Affiliations

    • Department of Pediatrics, Warren Alpert Medical School of Brown University, Providence, RI
    • Corresponding Author InformationReprint requests: Dr. William Oh, Department of Pediatrics, Brown Medical School, Women and Infants' Hospital of Rhode Island, 101 Dudley Street, Suite 1100, Providence, RI 02905
    • ,
  • Rebecca Perritt, MS

      Affiliations

    • Research Triangle International, Research Triangle Park, NC
    • ,
  • Seetha Shankaran, MD

      Affiliations

    • Department of Pediatrics, Wayne State University, Detroit, MI
    • ,
  • Matthew Merritts, MD

      Affiliations

    • Department of Nuclear Imaging, Southwestern University, Dallas, TX
    • ,
  • Edward F. Donovan, MD

      Affiliations

    • Department of Pediatrics, University of Cincinnati, Cincinnati, OH
    • ,
  • Richard A. Ehrenkranz, MD

      Affiliations

    • Department of Pediatrics, Yale University, New Haven, CT
    • ,
  • T. Michael O'Shea, MD

      Affiliations

    • Department of Pediatrics, Wake Forest University, Wake Forest, NC
    • ,
  • Jon E. Tyson, MD

      Affiliations

    • Department of Pediatrics, University of Texas at Houston
    • ,
  • Abbot R. Laptook, MD

      Affiliations

    • Department of Pediatrics, Warren Alpert Medical School of Brown University, Providence, RI
    • ,
  • Abhik Das, PhD

      Affiliations

    • Research Triangle International, Research Triangle Park, NC
    • ,
  • Rosemary D. Higgins, MD

      Affiliations

    • NICHD NIH, NICHD Neonatal Research Network, Bethesda, MD

Received 4 October 2007 ,Revised 29 January 2008 ,Accepted 17 March 2008.

References 

  1. Robertson CMT, Finer NN, Grace MGA. School performance of survivors of neonatal encephalopathy associated with birth asphyxia at term. J Pediatr. 1989;114:753–760
  2. Shankaran S, Woldt E, Koepke T, Bedard MP, Nandayal R. Acute neonatal morbidity and long-term central nervous system sequelae of perinatal asphyxia in term infants. Early Hum Dev. 1991;25:135–148
  3. Shah S, Tracy M, Smyth J. Postnatal lactate as an early predictor of short-term outcome after intrapartum asphyxia. J Perinatol. 2004;24:16–20
  4. da Silva S, Hennebert N, Denis R, Wayenberg JL. Clinical value of a single postnatal lactate measurement after intrapartum asphyxia. Acta Paediatr. 2000;89:320–323
  5. Kruger K, Hallberg B, Blennow M, Kublickas M, Westgren M. Predictive value of fetal scalp blood lactate concentration and pH as markers of neurologic disability. Am J Obstet Gynecol. 1999;181:1072–1078
  6. Ma S, Shieh LI, Huang CC. High-resolution proton nuclear magnetic resonance studies of urine from asphyxiated newborn infants. Appl Biochem Biotechnol. 1995;53:37–51
  7. Zuppi C, Messana I, Forni F, Rossi C, Pennacchietti L, Ferrari F, et al. 1H NMR spectra of normal urines: reference ranges of the major metabolites. Clin Chim Acta. 1997;265:85–97
  8. Huang CC, Wang Chang YC, Lin KP, Wu PL. Measurement of the urinary lactate: creatinine ratio for the early identification of newborn infants at risk for hypoxic-ischemic encephalopathy. N Engl J Med. 1999;341:328–335
  9. Shankaran S, Laptook AR, Ehrenkranz RE, Tyson JE, McDonald SA, Donovan EF, et al. Whole body hypothermia reduces death or disability in neonates with hypoxic-ischemic encephalopathy. N Engl J Med. 2005;353:1574–1584
  10. Ambalavanan N, Carlo WA, Shankaran S, Bann CM, Emrich SL, Higgins RD, et al. Predicting outcomes of neonates diagnosed with hypoxemic-ischemic encephalopathy. Pediatrics. 2006;118:2084-2003

 Supported by Neonatal Research Network NICHD. The list of grant support for each participating center is available at www.jpeds.com. Authors declare no conflict of interest.

PII: S0022-3476(08)00206-0

doi: 10.1016/j.jpeds.2008.03.041

The Journal of Pediatrics
Volume 153, Issue 3 , Pages 375-378.e2 , September 2008

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