The Journal of Pediatrics
Volume 153, Issue 1 , Pages 9-11 , July 2008

Reduced Iron Stores and Its Effect on Vasovagal Syncope (Simple Faint)

  • Julian M. Stewart, MD, PhD

      Affiliations

    • Corresponding Author InformationReprint requests: Julian M. Stewart, MD, PhD, Research Division and Hypotension Laboratory, New York Medical College, Suite 3050, 19 Bradhurst Ave, Hawthorne, NY 10532.

References 

  1. Huma N, Salim UR, Anjum FM, Murtaza MA, Sheikh MA. Food fortification strategy—preventing iron deficiency anemia: a review. Crit Rev Food Sci Nutr. 2007;47:259–265
  2. Tsiftsoglou AS, Tsamadou AI, Papadopoulou LC. Heme as key regulator of major mammalian cellular functions: molecular, cellular, and pharmacological aspects. Pharmacol Ther. 2006;111:327–345
  3. Dallman PR. Biochemical basis for the manifestations of iron deficiency. Annu Rev Nutr. 1986;6:13–40
  4. Milman N, Backer V, Laursen EM, Graudal N, Ibsen KK, Jordal R. Serum ferritin in children and adolescents (Results from population surveys in 1979 and 1986 comprising 1312 individuals). Eur J Haematol. 1994;53:16–20
  5. Rogers JT. Ferritin translation by interleukin-1and interleukin-6: the role of sequences upstream of the start codons of the heavy and light subunit genes. Blood. 1996;87:2525–2537
  6. Baumann-Blackmore NL, Goetz E, Blohowiak SE, Kling PJ. Cord blood zinc protoporphyrin/heme ratio in minority neonates at-risk for iron deficiency. J Pediatr. 2008;153:133–136
  7. Lozoff B, Kaciroti N, Walter T. Iron deficiency in infancy: applying a physiologic framework for prediction. Am J Clin Nutr. 2006;84:1412–1421
  8. Hebert PC, Van der LP, Biro G, Hu LQ. Physiologic aspects of anemia. Crit Care Clin. 2004;20:187–212
  9. Oski FA, Gottlieb AJ. The interrelationships between red blood cell metabolites, hemoglobin, and the oxygen-equilibrium curve. Prog Hematol. 1971;7:33–67
  10. Brannon ES, Merrill AJ, Warren JV, Stead EA. The cardiac output in patients with chronic anemia as measured by the technique of right atrial catheterization. J Clin Invest. 1945;24:332–336
  11. O'Leary DS, Sala-Mercado JA, Hammond RL, Ansorge EJ, Kim JK, Rodriguez J, et al. Muscle metaboreflex-induced increases in cardiac sympathetic activity vasoconstrict the coronary vasculature. J Appl Physiol. 2007;103:190–194
  12. Duke M, Abelmann WH. The hemodynamic response to chronic anemia. Circulation. 1969;39:503–515
  13. Murray JF, Escobar E, Rapaport E. Effects of blood viscosity on hemodynamic responses in acute normovolemic anemia. Am J Physiol. 1969;216:638–642
  14. Metivier F, Marchais SJ, Guerin AP, Pannier B, London GM. Pathophysiology of anaemia: focus on the heart and blood vessels. Nephrol Dial Transplant. 2000;15(Suppl 3):14–18
  15. Ignarro LJ. Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein. Circ Res. 1989;65:1–21
  16. Martin W, Smith JA, White DG. The mechanisms by which haemoglobin inhibits the relaxation of rabbit aorta induced by nitrovasodilators, nitric oxide, or bovine retractor penis inhibitory factor. Br J Pharmacol. 1986;89:563–571
  17. Rother RP, Bell L, Hillmen P, Gladwin MT. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. JAMA. 2005;293:1653–1662
  18. Choi JW, Pai SH, Kim SK, Ito M, Park CS, Cha YN. Iron deficiency anemia increases nitric oxide production in healthy adolescents. Ann Hematol. 2002;81:1–6
  19. Duffy SJ, Biegelsen ES, Holbrook M, Russell JD, Gokce N, Keaney JF, et al. Iron chelation improves endothelial function in patients with coronary artery disease. Circulation. 2001;103:2799–2804
  20. Gaenzer H, Marschang P, Sturm W, Neumayr G, Vogel W, Patsch J, et al. Association between increased iron stores and impaired endothelial function in patients with hereditary hemochromatosis. J Am Coll Cardiol. 2002;40:2189–2194
  21. Fernandez-Real JM, Penarroja G, Castro A, Garcia-Bragado F, Lopez-Bermejo A, Ricart W. Blood letting in high-ferritin type 2 diabetes: effects on vascular reactivity. Diabetes Care. 2002;25:2249–2255
  22. Jarjour IT, Jarjour LK. Low iron storage in children and adolescents with neurally mediated syncope. J Pediatr. 2008;153:40–44
  23. Frishman WH, Azer V, Sica D. Drug treatment of orthostatic hypotension and vasovagal syncope. Heart Dis. 2003;5:49–64
  24. Mosqueda-Garcia R, Furlan R, Md JT, Fernandez-Violante R. The elusive pathophysiology of neurally mediated syncope [In Process Citation]. Circulation. 2000;102:2898–2906
  25. Benditt DG, Ermis C, Padanilam B, Samniah N, Sakaguchi S. Catecholamine response during haemodynamically stable upright posture in individuals with and without tilt-table induced vasovagal syncope. Europace. 2003;5:65–70
  26. Sra JS, Murthy V, Natale A, Jazayeri MR, Dhala A, Deshpande S, et al. Circulatory and catecholamine changes during head-up tilt testing in neurocardiogenic (vasovagal) syncope. Am J Cardiol. 1994;73:33–37
  27. Noble BJ, Drinkhill MJ, Myers DS, Hainsworth R. Reflex control of splanchnic blood volume in anaesthetized dogs. J Physiol. 1998;513(Pt 1):263–272
  28. Stewart JM, McLeod KJ, Sanyal S, Herzberg G, Montgomery LD. Relation of postural vasovagal syncope to splanchnic hypervolemia in adolescents. Circulation. 2004;110:2575–2581
  29. Tani H, Singer W, McPhee BR, Opfer-Gehrking TL, Haruma K, Kajiyama G, et al. Splanchnic-mesenteric capacitance bed in the postural tachycardia syndrome (POTS). Auton Neurosci. 2000;86:107–113
  30. Koma LM, Kirberger RM, Scholtz L, Bland-van den Berg P. Influence of normovolemic anemia on Doppler-derived blood velocity ratios of abdominal splanchnic vessels in clinically normal dogs. Vet Radiol Ultrasound. 2005;46:427–433
  31. Dietz NM, Halliwill JR, Spielmann JM, Lawler LA, Papouchado BG, Eickhoff TJ, et al. Sympathetic withdrawal and forearm vasodilation during vasovagal syncope in humans. J Appl Physiol. 1997;82:1785–1793
  32. Vaziri ND, Ding Y, Sangha DS, Purdy RE. Upregulation of NOS by simulated microgravity, potential cause of orthostatic intolerance. J Appl Physiol. 2000;89:338–344

PII: S0022-3476(08)00202-3

doi: 10.1016/j.jpeds.2008.03.010

The Journal of Pediatrics
Volume 153, Issue 1 , Pages 9-11 , July 2008