The Journal of Pediatrics
Volume 153, Issue 2 , Pages 164-169 , August 2008

The Prevalence of Neonatal Herpes Simplex Virus Infection Compared with Serious Bacterial Illness in Hospitalized Neonates

  • A. Chantal Caviness, MD, PhD

      Affiliations

    • Section of Pediatric Emergency Medicine, Houston, TX
    • Corresponding Author InformationReprint requests: A. Chantal Caviness, MD, PhD, Texas Children's Hospital; 6621 Fannin St, MC 1-1841; Houston, TX 77030.
    • ,
  • Gail J. Demmler, MD

      Affiliations

    • Section of Infectious Disease, Houston, TX
    • Diagnostic Virology Laboratory, Texas Children's Hospital, Houston, TX
    • ,
  • Yvette Almendarez, MD

      Affiliations

    • Department of Pediatrics, Baylor College of Medicine, Houston, TX
    • ,
  • B.J. Selwyn, ScD

      Affiliations

    • University of Texas School of Public Health, Houston, TX.

Received 11 September 2007 ,Revised 14 December 2007 ,Accepted 14 February 2008.

References 

  1. Kimberlin DW, Lin CY, Jacobs RF, Powell DA, Frenkel LM, Gruber WC, et al. Natural history of neonatal herpes simplex virus infections in the acyclovir era. Pediatrics. 2001;108:223–229
  2. King C. Evaluation and management of febrile infants in the emergency department. Emerg Med Clin North Am. 2003;21:89–99vi-vii.
  3. Baraff LJ, Bass JW, Fleisher GR, Klein JO, McCracken GH, Powell KR, et al. Practice guideline for the management of infants and children 0 to 36 months of age with fever without source (Agency for Health Care Policy and Research). Ann Emerg Med. 1993;22:1198–1210
  4. Baraff LJ. Management of fever without source in infants and children. Ann Emerg Med. 2000;36:602–614
  5. American Academy of PediatricsCommittee on Infectious Diseases. Red Book: 2006 Report of the Committee on Infectious Diseases. Elk Grove Village, IL: American Academy of Pediatrics; 2006;
  6. Filippine MM, Katz BZ. Neonatal herpes simplex virus infection presenting with fever alone. J Hum Virol. 2001;4:223–225
  7. Avner JR, Baker MD. Management of fever in infants and children. Emerg Med Clin North Am. 2002;20:49–67
  8. Clinical policy for children younger than three years presenting to the emergency department with fever. Ann Emerg Med. 2003;42:530–545
  9. Caviness A. Herpes simplex virus infection in hospitalized neonates: clinical epidemiology and cost-effectiveness analysis of testing and treatment strategies. [Unpublished Dissertation] Houston: UT School of Public Health; 2007;
  10. Whitley R, Arvin A, Prober C, Burchett S, Corey L, Powell D, et al. A controlled trial comparing vidarabine with acyclovir in neonatal herpes simplex virus infection (Infectious Diseases Collaborative Antiviral Study Group). N Engl J Med. 1991;324:444–449
  11. Troendle-Atkins J, Demmler GJ, Buffone GJ. Rapid diagnosis of herpes simplex virus encephalitis by using the polymerase chain reaction. J Pediatr. 1993;123:376–380
  12. Healthcare Cost and Utilization Project Kids' Inpatient Database (KID) 2003. Rockville, MD: Agency for Healthcare Research and Quality; 2003;www.hcup-us.ahrq.gov/kidoverview.jsp
  13. Krober MS, Bass JW, Powell JM, Smith FR, Seto DS. Bacterial and viral pathogens causing fever in infants less than 3 months old. Am J Dis Child. 1985;139:889–892
  14. Byington CL, Enriquez FR, Hoff C, Tuohy R, Taggart EW, Hillyard DR, et al. Serious bacterial infections in febrile infants 1 to 90 days old with and without viral infections. Pediatrics. 2004;113:1662–1666

PII: S0022-3476(08)00105-4

doi: 10.1016/j.jpeds.2008.02.031

The Journal of Pediatrics
Volume 153, Issue 2 , Pages 164-169 , August 2008

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