The Journal of Pediatrics
Volume 153, Issue 1 , Pages 12-15.e1 , July 2008

Improving the Treatment of Neonatal Seizures: National Institute of Neurological Disorders and Stroke Workshop Report

  • Faye S. Silverstein, MD

      Affiliations

    • Department of Pediatrics and Neurology University of Michigan, Ann Arbor, MI
    • Corresponding Author InformationReprint requests: Faye Silverstein, MD, University of Michigan, 1150 W. Medical Center Dr, Room 8301, Ann Arbor, MI 48109-5646.
    • ,
  • Frances E. Jensen, MD

      Affiliations

    • Department of Neurology, Children's Hospital, Harvard University, Boston, MA
    • ,
  • Terrie Inder, MD

      Affiliations

    • Department of Pediatrics, Washington University, St. Louis, MO
    • ,
  • Lena Hellstrom-Westas, MD

      Affiliations

    • Department of Pediatrics, Uppsala University, Uppsala, Sweden
    • ,
  • Deborah Hirtz, MD

      Affiliations

    • National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD
    • ,
  • Donna M. Ferriero, MD

      Affiliations

    • Department of Neurology, University of California, San Francisco, San Francisco, CA.

Received 24 October 2007 ,Revised 19 December 2007 ,Accepted 30 January 2008.

References 

  1. Bittigau P, Sifringer M, Genz K, Reith E, Pospischil D, Govindarajalu S, et al Antiepileptic drugs and apoptotic neurodegeneration in the developing brain. Proc Natl Acad Sci USA. 2002;99:15089–15094
  2. Silverstein FS, Jensen FE. Neurological Progress: Neonatal Seizures. Ann Neurol. 2007;62:112–120
  3. Painter M, Scher MS, Stein AD, Armatti S, Wang Z, Gardiner JC, et al. Phenobarbital compared with phenytoin for the treatment of neonatal seizures. N Engl J Med. 1999;341:485–489
  4. Sankar R, Painter M. Neonatal seizures: after all these years we still love what doesn't work. Neurology. 2005;64:776–777
  5. Mizrahi E, Kellaway P. Characterization and classification of neonatal seizures. Neurology. 1987;37:1837–1844
  6. Hellström-Westas L, Rosén I, Svenningsen NW. Silent seizures in sick infants in early life. Acta Paediatr Scand. 1985;74:741–748
  7. Scher MS, Aso K, Beggarly ME, Hamid MY, Steppe DA, Painter MJ. Electrographic seizures in preterm and full-term neonates: clinical correlates, associated brain lesions, and risk for neurologic sequelae. Pediatrics. 1993;91:128–134
  8. Hellström-Westas L. Comparison between tape-recorded and amplitude-integrated EEG monitoring in sick newborn infants. Acta Paediatr. 1992;81:812–819
  9. Shah DK, Lavery S, Doyle LW, Wong C, McDougall P, Inder TE. Use of 2-channel bedside electroencephalogram monitoring in term-born encephalopathic infants related to cerebral injury defined by magnetic resonance imaging. Pediatrics. 2006;118:47–55
  10. Shany E, Khvatskin S, Golan A, Karplus M. Amplitude-integrated electroencephalography: a tool for monitoring silent seizures in neonates. Pediatr Neurol. 2006;34:194–199
  11. Rennie JM, Chorley G, Boylan G, Pressler R, Nguyen Y, Hooper R. Non-expert use of the cerebral function monitor for neonatal seizure detection. Arch Dis Child Fetal Neonatal Ed. 2004;89:F37–F40
  12. Shellhaas RA, Saoita AI, Clancy RR. The sensitivity of amplitude-integrated EEG for neonatal seizure detection. Pediatrics. 2007;120:770–777
  13. Toet MC, van der Meij W, de Vries LS, Uiterwaal CSPM, van Huffelen AC. Comparison between simultaneously recorded amplitude integrated EEG (Cerebral Function Monitor (CFM)) and standard EEG in neonates. Pediatrics. 2002;109:772–779
  14. Osredkar D, Toet MC, van Rooj LG, van Huffelen AC, Groenendaal F, de Vries LS. Sleep-wake cycling on amplitude-integrated electroencephalography in term newborns with hypoxic-ischemic encephalopathy. Pediatrics. 2005;115:327–332
  15. McBride MC, Laroia N, Guillet R. Electrographic seizures in neonates correlate with poor neurodevelopmental outcome. Neurology. 2000;55:506–513
  16. Tekgul H, Gauvreau K, Soul J, Murphy L, Roberson R, Stewart J, et al. The current etiologic profile and neurodevelopmental outcome of seizures in term newborn infants. Pediatrics. 2006;117:1270–1280
  17. Miller SP, Weiss J, Barnwell A, Ferriero DM, Latal-Hajnal B, Ferrer-Rogers A, et al. Seizure-associated brain injury in term newborns with perinatal asphyxia. Neurology. 2002;58:542–554
  18. Wirrell EC, Armstrong EA, Osman LD, Yager JY. Prolonged seizures exacerbate perinatal hypoxic-ischemic brain damage. Pediatr Res. 2001;50:445–454
  19. Silverstein FS, Ferriero DM. Challenges in improving the treatment of neonatal seizures. Ann Neurol. 2007;62:S139
  20. Clancy RR Neurology Group on Neonatal Seizures. The Newborn Drug Development Initiative Workshop: summary proceedings from the Neurology group on neonatal seizures. Clin Ther. 2006;28:1342–1352

 Funding for the workshop was provided by the National Institute of Neurological Disorders and Stroke and the Child Neurology Foundation.

PII: S0022-3476(08)00085-1

doi: 10.1016/j.jpeds.2008.01.041

The Journal of Pediatrics
Volume 153, Issue 1 , Pages 12-15.e1 , July 2008

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