The Journal of Pediatrics
Volume 153, Issue 2 , Pages 247-253 , August 2008

Prevalence and Predictors of Abnormal Liver Enzymes in Young Women with Anorexia Nervosa

  • Hiu-fai Fong, BS

      Affiliations

    • Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Children's Hospital Boston, Boston, MA
    • ,
  • Amy D. DiVasta, MD, MMSc

      Affiliations

    • Division of Adolescent Medicine, Children's Hospital Boston, Boston, MA
    • ,
  • Diane DiFabio, DTR, CDT

      Affiliations

    • General Clinical Research Center, Children's Hospital Boston, Boston, MA
    • ,
  • Julie Ringelheim, BA

      Affiliations

    • Division of Adolescent Medicine, Children's Hospital Boston, Boston, MA
    • ,
  • Maureen M. Jonas, MD

      Affiliations

    • Division of Gastroenterology and Nutrition, Children's Hospital Boston, Boston, MA
    • ,
  • Catherine M. Gordon, MD, MSc

      Affiliations

    • Division of Adolescent Medicine, Children's Hospital Boston, Boston, MA
    • Division of Endocrinology, Children's Hospital Boston, Boston, MA.
    • Corresponding Author InformationReprint requests: Catherine M. Gordon, MD, MSc, Divisions of Adolescent Medicine and Endocrinology, Children's Hospital Boston, 300 Longwood Ave, Boston, MA 02215.

Received 3 August 2007 ,Revised 20 November 2007 ,Accepted 25 January 2008.

References 

  1. De Caprio C, Alfano A, Senatore I, Zarrella L, Pasanisi F, Contaldo F. Severe acute liver damage in anorexia nervosa: Two case reports. Nutrition. 2006;22:572–575
  2. Di Pascoli L, Lion A, Milazzo D, Caregaro L. Acute liver damage in anorexia nervosa. Int J Eat Disord. 2004;36:114–117
  3. Rivera-Nieves J, Kozaiwa K, Parrish CR, Iezzoni J, Berg CL. Marked transaminase elevation in anorexia nervosa. Dig Dis Sci. 2000;45:1959–1963
  4. Furuta S, Ozawa Y, Maejima K, Tashiro H, Kitahora T, Hasegawa K, et al. Anorexia nervosa with severe liver dysfunction and subsequent critical complications. Intern Med. 1999;38:575–579
  5. Komuta M, Harada M, Ueno T, Uchimura Y, Inada C, Mitsuyama K, et al. Unusual accumulation of glycogen in liver parenchymal cells in a patient with anorexia nervosa. Intern Med. 1998;37:678–682
  6. Miller K, Grinspoon S, Ciampa J, Hier J, Herzog D, Klibanski A. Medical findings in outpatients with anorexia nervosa. Arch Intern Med. 2005;165:561–566
  7. Tajiri K, Shimizu Y, Tsuneyama K, Sugiyama T. A case report of oxidative stress in a patient with anorexia nervosa. Int J Eat Disord. 2006;39:616–618
  8. McLean AE. Hepatic failure in malnutrition. Lancet. 1962;280:1292–1294
  9. Pannacciulli N, Vettor R, Milan G, Granzotto M, Catucci A, Federspil G, et al. Anorexia nervosa is characterized by increased adiponectin plasma levels and reduced nonoxidative glucose metabolism. J Clin Endocrinol Metab. 2003;88:1748–1752
  10. Franssila-Kallunki A, Rissanen A, Ekstrand A, Eriksson J, Saloranta C, Widen E, et al. Fuel metabolism in anorexia nervosa and simple obesity. Metabolism. 1991;40:689–694
  11. Marchesini G, Brizi M, Morselli-Labate A, Bianchi G, Bugianesi E, McCullough A, et al. Association of nonalcoholic fatty liver disease with insulin resistance. Am J Med. 1999;107:450–455
  12. Hadigan C, Anderson E, Miller K, Hubbard J, Herzog D, Klibanski A, et al. Assessment of macronutrient and micronutrient intake in women with anorexia nervosa. Int J Eat Disord. 2000;28:284–292
  13. Misra M, Tsai P, Anderson E, Hubbard J, Gallagher K, Soyka L, et al. Nutrient intake in community-dwelling adolescent girls with anorexia nervosa and in healthy adolescents. Am J Clin Nutr. 2006;84:698–706
  14. Solga S, Alkhuraishe A, Clark J, Torbenson M, Greenwald A, Diehl A, et al. Dietary composition and nonalcoholic fatty liver disease. Digestive Diseases and Sciences. 2004;49:1578–1583
  15. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. text revision (DSM-IV-TR). 4th edition. Washington, DC: American Psychiatric Press, Inc; 2000;
  16. Kuczmarski R, Ogden C, Grummer-Strawn L, Flegal K, Guo S, Wei R, et al. CDC growth charts: United States. Adv Data. 2000;314:1–27
  17. World Health Organization. Physical status: the use and interpretation of anthropometry (Report of a WHO Expert Committee. WHO Technical Report Series 854). Geneva: World Health Organization; 1995;
  18. In:  Otten J,  Hellwig JP,  Meyers LD editor. The dietary reference intakes: the essential guide to nutrient requirements. Washington, DC: National Academies Press; 2006;
  19. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  20. In:  Soldin S,  Brugnara C,  Wong E editor. Pediatric Reference Ranges. Washington, DC: AACC Press; 2003;
  21. Keskin M, Kurtoglu S, Kendirci M, Atabek M, Cevat Y. Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. J Pediatrics. 2005;115:500–503
  22. Ozawa Y, Shimizu T, Shishiba Y. Elevation of serum aminotransferase as a sign of multiorgan-disorders in severely emaciated anorexia nervosa. Intern Med. 1998;37:32–39
  23. Westerbacka J, Corner A, Tiikkainen M, Tamminen M, Vehkavaara S, Hakkinen A, et al. Women and men have similar amounts of liver and intra-abdominal fat, despite more subcutaneous fat in women: implications for sex differences in markers of cardiovascular risk. Diabetologia. 2004;47:1360–1369
  24. Czaja M. Liver injury in the setting of steatosis: Crosstalk between adipokine and cytokine. Hepatology. 2004;40:19–22
  25. Pagano C, Soardo G, Esposito W, Fallo F, Basan L, Donnini D, et al. Plasma adiponectin is decreased in nonalcoholic fatty liver disease. Eur J Endocrinol. 2005;152:113–118
  26. Tagami T, Satoh N, Usui T, Yamada K, Shimatsu A, Kuzuya H. Adiponectin in anorexia nervosa and bulimia nervosa. J Clin Endocrinol Metab. 2004;89:1833–1837
  27. Casper R. Carbohydrate metabolism and its regulatory hormones in anorexia nervosa. Psychiatr Res. 1996;62:85–96
  28. Boyar RM, Hellman LD, Roffwarg H, Katz J, Zumoff B, O'Connor J, et al. Cortisol secretion and metabolism in anorexia nervosa. N Engl J Med. 1977;296:190–193
  29. Musso G, Gambino R, De Michieli F, Cassader M, Rizzetto M, Durazzo M, et al. Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis. Hepatology. 2003;37:909–916
  30. Lavine JE. Vitamin E treatment of nonalcoholic steatohepatitis in children: a pilot study. J Pediatr. 2000;136:734–738
  31. Cohen J, Kaplan M. The SGOT/SGPT ratio: an indicator of alcoholic liver disease. Dig Dis Sci. 1979;24:835–838

 Supported by NIH grants RO1 HD 43869, 5T32 HD 043034-02, and M01-RR-2172 to the Children's Hospital Boston General Clinical Research Center; and a grant from the US Department of Defense (US Army, Bone, and Military Readiness Program).

PII: S0022-3476(08)00075-9

doi: 10.1016/j.jpeds.2008.01.036

The Journal of Pediatrics
Volume 153, Issue 2 , Pages 247-253 , August 2008

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