The Journal of Pediatrics
Volume 153, Issue 1 , Pages 112-116.e1 , July 2008

Cesarean Section and Risk of Severe Childhood Asthma: A Population-Based Cohort Study

  • Mette C. Tollånes, MD

      Affiliations

    • Section for Epidemiology and Medical Statistics, Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
    • Medical Birth Registry of Norway, Locus of Registry-Based Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
    • Corresponding Author InformationReprint requests: Mette C. Tollånes, MD, Department of Public Health and Primary Health Care, University of Bergen, Postboks 7804, N-5020 Bergen, Norway.
    • ,
  • Dag Moster, MD, PhD

      Affiliations

    • Section for Epidemiology and Medical Statistics, Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
    • Medical Birth Registry of Norway, Locus of Registry-Based Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
    • Department of Pediatrics, Haukeland University Hospital, Bergen, Norway.
    • ,
  • Anne K. Daltveit, PhD

      Affiliations

    • Section for Epidemiology and Medical Statistics, Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
    • Medical Birth Registry of Norway, Locus of Registry-Based Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
    • ,
  • Lorentz M. Irgens, MD, PhD

      Affiliations

    • Section for Epidemiology and Medical Statistics, Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
    • Medical Birth Registry of Norway, Locus of Registry-Based Epidemiology, Norwegian Institute of Public Health, Oslo, Norway

Received 14 May 2007 ,Revised 19 October 2007 ,Accepted 23 January 2008.

References 

  1. Ninan TK, Russell G. The changing picture of childhood asthma. Paediatr Respir Rev. 2000;1:71–78
  2. Medical Birth Registry of Norway. http://mfr-nesstar.uib.no/mfr/Accessed October 15, 2007
  3. Kalliomäki M, Isolauri E. Role of intestinal flora in the development of allergy. Curr Opin Allergy Clin Immunol. 2003;3:15–20
  4. Salminen S, Gibson GR, McCartney AL, Isolauri E. Influence of mode of delivery on gut microbiota composition in seven-year-old children. Gut. 2004;53:1388–1389
  5. Kolås T, Saugstad O, Daltveit A, Nilsen S, Oian P. Planned cesarean versus planned vaginal delivery at term: comparison of newborn infant outcomes. Am J Obstet Gynecol. 2006;195:1538–1543
  6. Smith GCS, Wood AM, White IR, Pell JP, Cameron AD, Dobbie R. Neonatal respiratory morbidity at term and the risk of childhood asthma. Arch Dis Child Fetal Neonatal Ed. 2004;89:956–960
  7. Xu B, Pekkanen J, Järvelin MR. Obstetric complications and asthma in childhood. J Asthma. 2000;37:589–594
  8. Kero J, Gissler M, Grönlund M-M, Kero P, Koskinen P, Hemminki E, et al. Mode of delivery and asthma: is there a connection?. Pediatr Res. 2002;52:6–11
  9. Håkansson S, Källén K. Caesarean section increases the risk of hospital care in childhood for asthma and gastroenteritis. Clin Exp Allergy. 2003;33:757–764
  10. Renz-Polster H, David MR, Buist AS, Vollmer WM, O'Connor EA, Frazier EA, et al. Caesarean section delivery and the risk of allergic disorders in childhood. Clin Exp Allergy. 2005;35:1466–1472
  11. Bager P, Melbye M, Rostgaard K, Benn CS, Westergaard T. Mode of delivery and risk of allergic rhinitis and asthma. J Allergy Clin Immunol. 2003;111:51–56
  12. Debley JS, Smith JM, Redding GJ, Critchlow CW. Childhood asthma hospitalization risk after cesarean delivery in former term and premature infants. Ann Allergy Asthma Immunol. 2005;94:228–233
  13. Bernsen RMD, de Jongste JC, Koes BW, Aardoom HA, van der Wouden JC. Perinatal characteristics and obstetric complications as risk factors for asthma, allergy and eczema at the age of 6 years. Clin Exp Allergy. 2005;35:1135–1140
  14. Juhn YJ, Weaver A, Katusic S, Yunginger J. Mode of delivery at birth and development of asthma: a population-based cohort study. J Allergy Clin Immunol. 2005;116:510–516
  15. Nafstad P, Magnus P, Jaakkola JJ. Risk of childhood asthma and allergic rhinitis in relation to pregnancy complications. J Allergy Clin Immunol. 2000;106:867–873
  16. McKeever TM, Lewis SA, Smith C, Hubbard R. Mode of delivery and risk of developing allergic disease. J Allergy Clin Immunol. 2002;109:800–802
  17. Maitra A, Sherriff A, Strachan D, Henderson J. Mode of delivery is not associated with asthma or atopy in childhood. Clin Exp Allergy. 2004;34:1349–1355
  18. Irgens L. The Medical Birth Registry of Norway: epidemiological research and surveillance throughout 30 years. Acta Obstet Gynecol Scand. 2000;79:435–439
  19. Borthen I, Lossius P, Skjaerven R, Bergsjø P. Changes in frequency and indications for cesarean section in Norway 1967-1984. Acta Obstet Gynecol Scand. 1989;68:589–593
  20. Rasmussen S, Albrechtsen S, Irgens LM, Dalaker K, Maartmann-Moe H, Vlatkovic L, et al. Unexplained antepartum fetal death in Norway, 1985-97: diagnostic validation and some epidemiologic aspects. Acta Obstet Gynecol Scand. 2003;82:109–115
  21. Moster D, Lie TR, Irgens ML, Bjerkedal T, Markestad T. The association of Apgar score with subsequent death and cerebral palsy: a population-based study in term infants. J Pediatr. 2001;138:798–803
  22. Theofilogiannakou M, Skouroliakou M, Gounaris A, Panagiotakos D, Markantonis SL. Breast-feeding in Athens, Greece: factors associated with its initiation and duration. J Pediatr Gastroenterol Nutr. 2006;43:379–384
  23. Chan-Yeung M, Becker A. Primary prevention of childhood asthma and allergic disorders. Curr Opin Allergy Clin Immunol. 2006;6:146–151
  24. Clausen T, Øyen N, Henriksen T. Pregnancy complications by overweight and residential area: a prospective study of an urban Norwegian cohort. Acta Obstet Gynecol Scand. 2006;85:526–533
  25. Liu S, Wen SW, Demissie K, Marcoux S, Kramer MS. Maternal asthma and pregnancy outcomes: a retrospective cohort study. Am J Obstet Gynecol. 2001;184:90–96
  26. Carlsen KH. Asthma: a condition of our time, a condition in change?. Tidsskr Nor Laegeforen. 2001;121:836–840
  27. Finnvold JE. Access to specialized health care for asthmatic children in Norway: the significance of parents' educational background and social network. Soc Sci Med. 2006;63:1316–1327
  28. Bjerkedal T, Thune O. Basic and attendance benefits to children: extent and medical causes. Tidsskr Nor Laegeforen. 1994;114:1941–1945[in Norwegian]
  29. Gerten KA, Coonrod DV, Bay RC, Chambliss LR. Cesarean delivery and respiratory distress syndrome: does labor make a difference?. Am J Obstet Gynecol. 2005;193:1061–1064

 This study was funded by the Research Council of Norway, which had no involvement in the authors' work.

 The authors have no conflicts of interest to declare.

PII: S0022-3476(08)00070-X

doi: 10.1016/j.jpeds.2008.01.029

The Journal of Pediatrics
Volume 153, Issue 1 , Pages 112-116.e1 , July 2008

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