The Journal of Pediatrics
Volume 152, Issue 5 , Pages 601-602 , May 2008

Which Comes First? The Obesity or the Insulin? The Behavior or the Biochemistry?

  • Robert H. Lustig, MD

      Affiliations

    • Corresponding Author InformationReprint requests: Robert H. Lustig, MD, Division of Pediatric Endocrinology, Box 0434, Room S-679, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94143-0434.

References 

  1. Mark AL, Rahmouni K, Correia M, Haynes WG. A leptin-sympathetic-leptin feedback loop: potential implications for regulation of arterial pressure and body fat. Acta Physiol Scand. 2003;177:345–349
  2. Lustig RH. Childhood obesity: behavioral aberration or biochemical drive? (Reinterpreting the first law of thermodynamics). Nat Clin Pract Endocrinol Metab. 2006;2:447–458
  3. Han JC, Rutledge MS, Kozlosky M, Salaita CG, Gustafson JK, Keil MF. Insulin resistance, hyperinsulinemia, and energy intake in overweight children. J Pediatr. 2008;152:612–617
  4. Preeyasombat C, Bacchetti P, Lazar AA, Lustig RH. Racial and etiopathologic dichotomies in insulin secretion and resistance in obese children. J Pediatr. 2005;146:474–481
  5. August GP, Caprio S, Fennoy IL, Freemark MC, Kaufman FR, Lustig RH. Prevention and treatment of pediatric obesity: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2008;In press
  6. Biddinger SB, Kahn CR. From mice to men: insights into the insulin resistance syndromes. Ann Rev Physiol. 2006;68:123–158
  7. Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med. 2005;11:183–190
  8. An J, Muoio DM, Shiota M, Fujimoto Y, Cline GW, Shulman GI, et al. Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance. Nat Med. 2004;10:268–274
  9. Brüning JC, Gautam D, Burks DJ, Gillette J, Schubert M, Orban PC, et al. Role of brain insulin receptor in control of body weight and reproduction. Science. 2000;289:2122–2125

PII: S0022-3476(08)00062-0

doi: 10.1016/j.jpeds.2008.01.021

The Journal of Pediatrics
Volume 152, Issue 5 , Pages 601-602 , May 2008

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