The Journal of Pediatrics
Volume 153, Issue 1 , Pages 105-111.e1 , July 2008

Prenatal Cocaine Exposure: Drug and Environmental Effects at 9 Years

  • Lynn T. Singer, PhD

      Affiliations

    • Department of Pediatrics, Case Western Reserve University, Cleveland, OH
    • Department of General Medical Sciences, Case Western Reserve University, Cleveland, OH
    • Department of Psychology, Case Western Reserve University, Cleveland, OH
    • Corresponding Author InformationCorrespondence: Lynn T. Singer, PhD, Case Western Reserve University, The Triangle Building, 11400 Euclid Ave, Suite 250-A, Cleveland, OH 44106.
    • ,
  • Suchitra Nelson, PhD

      Affiliations

    • Department of Community Dentistry, School of Dental Medicine, Case Western Reserve University, Cleveland, OH.
    • ,
  • Elizabeth Short, PhD

      Affiliations

    • Department of Psychology, Case Western Reserve University, Cleveland, OH
    • ,
  • Meeyoung O. Min, PhD

      Affiliations

    • Department of Pediatrics, Case Western Reserve University, Cleveland, OH
    • ,
  • Barbara Lewis, PhD

      Affiliations

    • Department of Pediatrics, Case Western Reserve University, Cleveland, OH
    • ,
  • Sandra Russ, PhD

      Affiliations

    • Department of Psychology, Case Western Reserve University, Cleveland, OH
    • ,
  • Sonia Minnes, PhD

      Affiliations

    • Department of General Medical Sciences, Case Western Reserve University, Cleveland, OH

Received 13 August 2007 ,Revised 9 November 2007 ,Accepted 2 January 2008.

References 

  1. National Household Survey on Drug Abuse Population Estimates, 1998. Rockville, MD: US Department of Health and Human Services, Substance Abuse And Mental Health Services Administration; 1999;
  2. Lidow MS. Consequences of prenatal cocaine exposure in nonhuman primates. Dev Brain Res. 2003;147:23–36
  3. Harvey JA. Cocaine effects on the developing brain: current status. Neurosci Biobehav Rev. 2004;27:751–764
  4. Nelson S, Singer LT, Lerner E, Needlman R, Salvator A. Anemia and neurodevelopmental outcomes in cocaine-exposed and non-exposed children: a longitudinal study. J Dev Behav Pediatr. 2004;25:1–9
  5. Singer LT, Salvator A, Arendt RE, Minnes S, Farkas K, Kliegman R. Effects of cocaine/polydrug exposure and maternal psychological distress on infant birth outcomes. Neurotoxicol Teratol. 2002;24:127–135
  6. Bauer CR, Langer JC, Shakaran S, Bada HS, Lester B, Wright LL, et al. Acute neonatal effects of cocaine exposure during pregnancy. Arch Pediatr Adolesc Med. 2005;159:824–834
  7. Singer LT, Minnes S, Arendt RE, Farkas K, Short E, Lewis B, et al. Cognitive outcomes of preschool children with prenatal cocaine exposure. JAMA. 2004;291:2248–2456
  8. Behnke M, Eyler FD, Warner TD, Garvan CW, Wei H, Wobie K. Outcome from a prospective longitudinal study of prenatal cocaine use: preschool development at 3 years of age. J Pediatr Psychol. 2006;31:41–49
  9. Bennett DS, Bendersky M, Lewis M. Children's intellectual and emotional-behavioral adjustment at 4 years as a function of cocaine exposure, maternal characteristics, and environmental risk. Dev Psychol. 2002;38:648–658
  10. Bandstra ES, Vogel AL, Morrow CE, Xue L, Anthony JC. Severity of prenatal cocaine exposure and child language functioning through age seven years: a longitudinal latent growth curve analysis. Substance Use Misuse. 2004;39:25–59
  11. Arendt R, Short E, Singer LT, Minnes S, Hewitt J, Flynn S, et al. Children prenatally exposed to cocaine: developmental outcomes and environmental risks at seven years of age. J Dev Behav Pediatr. 2004;25:83–90
  12. Hurt H, Brodsky NL, Roth H, Malmud E, Giannetta JM. School performance of children with gestational cocaine exposure. Neurotoxicol Teratol. 2005;27:203–211
  13. Singer LT, Arendt R, Minnes S, Farkas K, Salvator A, Kirchner HL, et al. Cognitive and motor outcomes of cocaine-exposed infants. JAMA. 2002;287:1952–1960
  14. Dunn L, Dunn L. Peabody Picture Vocabulary Test–Revised. Circle Pines, MN: American Guidance Service; 1981;
  15. Wechsler D. Weschler Adult Intelligence Scale–Revised. San Antonio, TX: The Psychological Corporation; 1989;
  16. Derogatis L. The Brief Symptom Inventory: Administration, Scoring, and Procedures Manual. 2nd edition. Baltimore, MD: Clinical Psychometric Research Inc; 1992;
  17. Hobel CJ, Hyvarinen MA, Okada DM, Oh W. Prenatal and intrapartum high-risk screening, I: prediction of the high-risk neonate. Am J Obstet Gynecol. 1973;117:1–9
  18. Oski FA. Iron deficiency in infancy and childhood. N Eng J Med. 1993;329:190–193
  19. Wechsler D. Wechsler Intelligence Scale for Children–Fourth Edition. San Antonio, TX: The Psychological Corporation; 2003;
  20. Woodcock RW, McGraw KS, Mather N. Woodcock-Johnson–III. Itasca, IL: Riverside Publishing; 2001;
  21. Caldwell B, Bradley R. Home Observation for Measurement of the Environment. Little Rock, AK: University of Arkansas Press; 1984;
  22. Williams PE, Weiss LG, Rolfhus E. WISC-IV Technical Report 1: Theoretical Model and Test Blueprint. San Antonio, TX: The Psychological Corporation; 2003;
  23. Singer LT, Lewin J, Minnes S, Weishampel P, Drake K, Satayathum S, et al. Neuroimaging of 7- to 8-year-old children exposed prenatally to cocaine. Neurotoxicol Teratol. 2006;28:386–402
  24. Warner TD, Behnke M, Eyler FD, Padgett K, Leonard C, Hou W, et al. Diffusion tensor imaging of frontal white matter and executive functioning in cocaine-exposed children. Pediatrics. 2006;118:2014–2024
  25. Lanphear BP. Childhood lead poisoning prevention: too little, too late. JAMA. 2006;293:2274
  26. Chung EK, Webb D, Clampet-Lundquist S, Campbell C. A comparison of elevated blood lead levels among children living in foster care, their siblings, and the general population. Pediatrics. 2001;107:1–5
  27. Chiodo LM, Jacobson SW, Jacobson JL. Neurodevelopmental effects of postnatal lead exposure at very low levels. Neurotoxicol Teratol. 2004;26:359–371
  28. Burden MJ, Jacobson SW, Sokol RJ, Jacobson JL. Effects of prenatal alcohol exposure on attention and working memory at 7.5 years of age. Alcohol Clin Exp Res. 2005;29:443–452
  29. Richardson GA, Ryan C, Wilford J, Day NL, Goldschmidt L. Prenatal alcohol and marijuana exposure: effects on neuropsychological outcomes at 10 years. Neurotoxicol Teratol. 2002;24:309–320
  30. Walter T. Effect of iron-deficiency anemia on cognitive skills and neuromaturation in infancy and childhood. Food Nutr Bull. 2003;24:S104–S110
  31. Lozoff B, Jimenez E, Hagen J, Mollen E, Wolf AW. Poorer behavioral and developmental outcome more than 10 years after treatment for iron deficiency in infancy. Pediatrics. 2000;105:e51
  32. Fried PA, Watkinson B, Gray R. Differential effects on cognitive functioning in 13- to 16-year-olds prenatally exposed to cigarettes and marijuana. Neurotoxicol Teratol. 2003;25:427–436
  33. Carter RC, Jacobson SW, Molteno CD, Jacobson JL. Fetal alcohol exposure, iron-deficiency anemia, and infant growth. Pediatrics. 2007;120:559–567

 Supported by the National Institute on Drug Abuse (grants RO1-DA07957 [L.S.] and RO3-DA11764 [S.N.]) and the Schubert Center at Case Western Reserve University (S.N.).

 None of the authors has any conflict of interest to report.

 No reprints are available from the authors.

PII: S0022-3476(08)00002-4

doi: 10.1016/j.jpeds.2008.01.001

The Journal of Pediatrics
Volume 153, Issue 1 , Pages 105-111.e1 , July 2008

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