The Journal of Pediatrics
Volume 153, Issue 1 , Pages 84-88 , July 2008

A 10-Year Prospective Study of Sensorineural Hearing Loss in Children with Congenital Cytomegalovirus Infection

  • Ina Foulon, MD

      Affiliations

    • Department of Otolaryngology and Head and Neck Surgery, University Hospital Brussels, Free University Brussels, Belgium
    • Corresponding Author InformationReprint requests: Ina Foulon, ENT Dept, Universitair Ziekenhuis Brussels, Laarbeeklaan 101, 1090 Brussels, Belgium.
    • ,
  • Anne Naessens, MD, PhD

      Affiliations

    • Department of Microbiology, University Hospital Brussels, Free University Brussels, Belgium
    • ,
  • Walter Foulon, MD, PhD

      Affiliations

    • Department of Obstetrics, University Hospital Brussels, Free University Brussels, Belgium
    • ,
  • Ann Casteels, MD

      Affiliations

    • Department of Neonatology, University Hospital Brussels, Free University Brussels, Belgium.
    • ,
  • Frans Gordts, MD, PhD

      Affiliations

    • Department of Otolaryngology and Head and Neck Surgery, University Hospital Brussels, Free University Brussels, Belgium

Received 11 June 2007 ,Revised 5 October 2007 ,Accepted 17 December 2007.

References 

  1. Kenneson A, Cannon MJ. Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection. Rev Med Virol. 2007;17:253–276
  2. Nance WE, Lim BG, Dodson KM. Importance of congenital cytomegalovirus infections as a cause for pre-lingual hearing loss. J Clin Virol. 2006;35:221–225
  3. Williamson WD, Demmler GJ, Percy AK, Catlin FI. Progressive hearing loss in infants with asymptomatic congenital cytomegalovirus infection. Pediatrics. 1992;90:862–866
  4. Fowler KB, McCollister FP, Dahle AJ, Boppana S, Britt WJ, Pass RF. Progressive and fluctuating sensorineural hearing loss in children with asymptomatic congenital cytomegalovirus infection. J Pediatr. 1997;130:624–630
  5. Naessens A, Casteels A, Decatte L, Foulon W. A serologic strategy for detection neonates at risk for congenital cytomegalovirus infection. J Pediatr. 2005;146:194–197
  6. Joint Committee on Infant Hearing. Year 2000 position statement: principles and guidelines for early hearing detection and intervention programs. Pediatrics. 2000;106:798–817
  7. Gordts F, Naessens B, Mudde CA, Clement PAR. Reference data for DPOAE in healthy newborns. Scand Audiol. 1999;28:1–5
  8. Grundfast KM, Siparsky NF. Hearing loss. In:  Bluestone CD,  Stool ES,  Alper CM,  Arjmand EM,  Casselbrant ML,  Dohar JE, et al. editor. Pediatric Otolaryngology. 4th edition. Philadelphia: Saunders; 2003;p. 306–350
  9. Dahle AJ, Fowler KB, Wright JD, Boppana SB, Britt WJ, Pass RF. Longitudinal investigation of hearing disorders in children with congenital cytomegalovirus. J Am Acad Audiol. 2000;11:283–290
  10. Iwasaki S, Yamashita M, Maeda M, Misawa K, Mineta H. Audiological outcome of infants with congenital cytomegalovirus infection in a prospective study. Audiol Neurotol. 2007;12:13–36
  11. Fowler KB, Boppana SB. Congenital cytomegalovirus infection and hearing deficit. J Clin Virol. 2006;35:226–231
  12. Pass RF, Fowler KB, Boppana SB, Britt WJ, Stagno S. Congenital cytomegalovirus infection following first trimester maternal infection: symptoms at birth and outcome. J Clin Virol. 2006;35:216–220
  13. Kind en Gezin (www.kindengezin.be). Van Kerschaver E, Stappaerts L, Buysse B. Kind en Gezin: Gehoorscreening in Vlaanderen 2004. Annual Report 2004. Available at www.kindengezin.be/KG/Algemeen/Over_Kind_En_Gezin/Rapporten/default.jsp.
  14. Fowler KB, Dahle AJ, Boppana SB, Pass RF. Newborn hearing screening: will children with hearing loss caused by congenital cytomegalovirus infection be missed?. J Pediatr. 1999;135:60–64
  15. Kimberlin DW, Lin CY, Sanchez PJ, Demmler GJ, Dankner W, Shelton M, et al. Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial. J Pediatr. 2003;143:16–25
  16. Ross SA, Fowler KB, Ashrith G, Stagno S, Britt WJ, Pass RF, et al. Hearing loss in children with congenital cytomegalovirus infection born to mothers with preexisting immunity. J Pediatr. 2006;148:332–336
  17. Casteels A, Naessens A, Gordts F, De Catte L, Bougatef A, Foulon W. Neonatal screening for congenital cytomegalovirus infections. J Perinat Med. 1999;27:116–121
  18. Ahlfors K, Ivarsson SA, Harris S. Report on a long-term study of maternal and congenital cytomegalovirus infection in Sweden: review of prospective studies available in the literature. Scand J Infect Dis. 1999;31:443–457
  19. Griffiths PD, Baboonian C, Rutter D, Peckham C. Congenital and maternal cytomegalovirus infections in a London population. Br J Obstet Gynaecol. 1991;98:135–140
  20. Lanari M, Lazzarotto T, Venturi V, Papa I, Gabrielli L, Guerra B, et al. Neonatal cytomegalovirus blood load and risk of sequelae in symptomatic and asymptomatic congenitally infected newborns. Pediatrics. 2006;117:76–83
  21. Bradford RD, Cloud G, Lakeman AD, Boppana S, Kimberlin DW, Jacobs R, et al. Detection of cytomegalovirus (CMV) DNA by polymerase chain reaction is associated with hearing loss in newborns with symptomatic congenital CMV infection involving the central nervous system. J Infect Dis. 2005;19:227–233

PII: S0022-3476(07)01188-2

doi: 10.1016/j.jpeds.2007.12.049

The Journal of Pediatrics
Volume 153, Issue 1 , Pages 84-88 , July 2008

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