Use of the MRI technique, diffusion tensor imaging, in children with global developmental delay

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Sundaram et al from Wayne State University have used the new MRI technique, diffusion tensor imaging, to evaluate children with global developmental delay of unknown etiology. They found that in a significant proportion of patients, the arcuate fasciculus was absent. They also found that there was an abnormal maturation of the inferior longitudinal fasciculus in a high proportion of the group with developmental delay. This paper shows the utility of using diffusion tensor imaging for mapping the central connections in children with developmental delay whose scans are often normal using conventional techniques.