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The Journal of Pediatrics
Volume 152, Issue 5
, Pages 612-617.e1
, May 2008
Insulin Resistance, Hyperinsulinemia, and Energy Intake in Overweight Children
References
- Weight gain and the risk of developing insulin resistance syndrome. Diabetes Care. 1998;21:1637–1643
- . Adiposity in childhood predicts obesity and insulin resistance in young adulthood. J Pediatr. 2001;138:469–473
- . Acute postchallenge hyperinsulinemia predicts weight gain: a prospective study. Diabetes. 1997;46:1025–1029
- Insulin, C-peptide, and leptin concentrations predict increased visceral adiposity at 5- and 10-year follow-ups in nondiabetic Japanese Americans. Diabetes. 2005;54:985–990
- Insulin resistance associated with lower rates of weight gain in Pima Indians. J Clin Invest. 1991;88:168–173
- Predictors of weight change in a bi-ethnic population (The San Antonio Heart Study). Int J Obes Relat Metab Disord. 1994;18:85–91
- . High fasting insulin levels associated with lower rates of weight gain in persons with normal glucose tolerance: the San Luis Valley Diabetes Study. Int J Obes Relat Metab Disord. 1995;19:175–180
- . Fasting hyperinsulinemia is a predictor of increased body weight gain and obesity in Pima Indian children. Diabetes. 1997;46:1341–1345
- . Longitudinal changes in body fat in African American and Caucasian children: influence of fasting insulin and insulin sensitivity. J Clin Endocrinol Metab. 2001;86:3182–3187
- Metabolic and behavioral predictors of weight gain in Hispanic children: the Viva la Familia Study. Am J Clin Nutr. 2007;85:1478–1485
- . Insulin resistance during puberty and future fat accumulation. J Clin Endocrinol Metab. 2002;87:3814–3818
- . Insulin resistance and the persistence of obesity from childhood into adulthood. J Clin Endocrinol Metab. 2002;87:71–76
- . Insulin in the brain: a hormonal regulator of energy balance. Endocr Rev. 1992;13:387–414
- Cerebrospinal fluid insulin levels increase during intravenous insulin infusions in man. J Clin Endocrinol Metab. 1987;64:190–194
- Saturable transport of insulin from plasma into the central nervous system of dogs in vivo (A mechanism for regulated insulin delivery to the brain). J Clin Invest. 1993;92:1824–1830
- Cross-talk between the insulin and leptin signaling systems in rat hypothalamus. Obes Res. 2005;13:48–57
- Role of brain insulin receptor in control of body weight and reproduction. Science. 2000;289:2122–2125
- Intraventricular insulin reduces food intake and body weight of lean but not obese Zucker rats. Appetite. 1986;7:381–386
- . Insulin and the CNS: effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans. Physiol Behav. 2004;83:47–54
- . Appetite dysfunction in obese males: evidence for role of hyperinsulinaemia in passive overconsumption with a high fat diet. Eur J Clin Nutr. 2000;54:225–233
- Associations between postprandial insulin and blood glucose responses, appetite sensations and energy intake in normal weight and overweight individuals: a meta-analysis of test meal studies. Br J Nutr. 2007;98:17–25
- . Insulin binding to brain capillaries is reduced in genetically obese, hyperinsulinemic Zucker rats. Peptides. 1990;11:467–472
- Anon. Effects of metformin on Energy Intake, Energy Expenditure, and Body Weight in Overweight Children with Insulin. Resistance: NCT00005669. In: National Institutes of Health Clinical Center, NIH Clinical Research Studies. Bethesda, Maryland 20892; accessed Nov. 7, 2005; 2000.
- . Measuring binge eating in adolescents: adolescent and parent versions of the questionnaire of eating and weight patterns. Int J Eat Disord. 1999;26:301–314
- Estimation of body fatness by air displacement plethysmography in African American and white children. Pediatr Res. 2001;50:467–473
- . Radiographic atlas of skeletal development of the hand and wrist. 2nd ed.. Stanford: Standford University Press; 1959;
- . The metabolic syndrome in overweight Hispanic youth and the role of insulin sensitivity. J Clin Endocrinol Metab. 2004;89:108–113
- Effects of binge eating on satiation, satiety, and energy intake of overweight children. Am J Clin Nutr. 2006;84:732–738
- . Hollingshead two factor index of social position (1957). In: Miller DC editors. Handbook of research design and social measurement. 5th ed.. Newbury Park, CA: Sage Publications; 1991;p. 351–359
- . Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 1979;237:E214–E223
- . Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
- Insulin secretion and clearance (Comparison after oral and intravenous glucose). Diabetes. 1987;36:1365–1371
- Regulation of SOCS-3 expression by leptin and its co-localization with insulin receptor in rat skeletal muscle cells. Mol Cell Endocrinol. 2007;267:38–45
- . SOCS-3 is an insulin-induced negative regulator of insulin signaling. J Biol Chem. 2000;275:15985–15991
- . Childhood obesity: behavioral aberration or biochemical drive? (Reinterpreting the First Law of Thermodynamics). Nat Clin Pract Endocrinol Metab. 2006;2:447–458
- . Insulin resistance and improvements in signal transduction. Endocrine. 2006;29:73–80
- Octreotide therapy of pediatric hypothalamic obesity: a double-blind, placebo-controlled trial. J Clin Endocrinol Metab. 2003;88:2586–2592
- . Insulin dynamics predict body mass index and z-score response to insulin suppression or sensitization pharmacotherapy in obese children. J Pediatr. 2006;148:23–29
- The limitations to and valid use of C-peptide as a marker of the secretion of insulin. Diabetes. 1986;35:379–386
- . Estimation of insulin secretion rates from C-peptide levels (Comparison of individual and standard kinetic parameters for C-peptide clearance). Diabetes. 1992;41:368–377
- . Peripheral insulin parallels changes in insulin secretion more closely than C-peptide after bolus intravenous glucose administration. J Clin Endocrinol Metab. 1988;67:1094–1099
Supported by the Intramural Research Program of the NIH with the grant ZO1 HD-00641 (to JAY) from the National Institute of Child Health and Human Development and by a supplement from the National Center for Minority Health and Health Disparities (to JAY), National Institutes of Health. AFF was supported by the NIH Clinical Research Training Program, a public-private partnership funded jointly by the NIH and a grant to the Foundation for the NIH from Pfizer Pharmaceuticals Group. J.C.H., M.K., and J.A.Y. are Commissioned Officers in the United States Public Health Service, DHHS.
PII: S0022-3476(07)01170-5
doi: 10.1016/j.jpeds.2007.12.036
© 2008 Mosby, Inc. All rights reserved.
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The Journal of Pediatrics
Volume 152, Issue 5
, Pages 612-617.e1
, May 2008
