The Journal of Pediatrics
Volume 153, Issue 1 , Pages 117-121.e3 , July 2008

Resistance to Intravenous Immunoglobulin in Children with Kawasaki Disease

  • Adriana H. Tremoulet, MD

      Affiliations

    • Department of Pediatrics, University of California San Diego School of Medicine and Rady Children's Hospital San Diego, San Diego, CA
    • ,
  • Brookie M. Best, PharmD

      Affiliations

    • Department of Pediatrics, University of California San Diego School of Medicine and Rady Children's Hospital San Diego, San Diego, CA
    • Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA
    • ,
  • Sungchan Song, BS

      Affiliations

    • Department of Pediatrics, University of California San Diego School of Medicine and Rady Children's Hospital San Diego, San Diego, CA
    • ,
  • Susan Wang

      Affiliations

    • Department of Pediatrics, University of California San Diego School of Medicine and Rady Children's Hospital San Diego, San Diego, CA
    • ,
  • Elena Corinaldesi, MD

      Affiliations

    • Department of Pediatrics, University of California San Diego School of Medicine and Rady Children's Hospital San Diego, San Diego, CA
    • ,
  • Julia R. Eichenfield

      Affiliations

    • Department of Pediatrics, University of California San Diego School of Medicine and Rady Children's Hospital San Diego, San Diego, CA
    • ,
  • Danielle D. Martin, BS

      Affiliations

    • Department of Cardiology, Children's Hospital Boston, Boston, MA.
    • ,
  • Jane W. Newburger, MD, MPH

      Affiliations

    • Department of Cardiology, Children's Hospital Boston, Boston, MA.
    • ,
  • Jane C. Burns, MD

      Affiliations

    • Department of Pediatrics, University of California San Diego School of Medicine and Rady Children's Hospital San Diego, San Diego, CA

Received 4 July 2007 ,Revised 22 October 2007 ,Accepted 10 December 2007.

References 

  1. Newburger JW, Takahashi M, Beiser AS, Burns JC, Bastian J, Chung KJ, et al. A single intravenous infusion of gamma globulin as compared with four infusions in the treatment of acute Kawasaki syndrome. N Engl J Med. 1991;324:1633–1639
  2. Durongpisitkul K, Soongswang J, Laohaprasitiporn D, Nana A, Prachuabmoh C, Kangkagate C. Immunoglobulin failure and retreatment in Kawasaki disease. Pediatr Cardiol. 2003;24:145–148
  3. Han RK, Silverman ED, Newman A, McCrindle BW. Management and outcome of persistent or recurrent fever after initial intravenous gamma globulin therapy in acute Kawasaki disease. Arch Pediatr Adolesc Med. 2000;154:694–699
  4. Kashef S, Safari M, Amin R. Initial intravenous gamma-globulin treatment failure in Iranian children with Kawasaki disease. Kaohsiung J Med Sci. 2005;21:401–404
  5. Burns JC, Capparelli EV, Brown JA, Newburger JW, Glode MP. Intravenous gamma-globulin treatment and retreatment in Kawasaki disease (US/Canadian Kawasaki Syndrome Study Group). Pediatr Infect Dis J. 1998;17:1144–1148
  6. Sittiwangkul R, Pongprot Y, Silvilairat S, Phornphutkul C. Management and outcome of intravenous gammaglobulin-resistant Kawasaki disease. Singapore Med J. 2006;47:780–784
  7. Mori M, Imagawa T, Katakura S, Miyamae T, Okuyama K, Ito S, et al. Efficacy of plasma exchange therapy for Kawasaki disease intractable to intravenous gamma-globulin. Mod Rheumatol. 2004;14:43–47
  8. Hashino K, Ishii M, Iemura M, Akagi T, Kato H. Re-treatment for immune globulin-resistant Kawasaki disease: a comparative study of additional immune globulin and steroid pulse therapy. Pediatr Int. 2001;43:211–217
  9. Sundel RP, Burns JC, Baker A, Beiser AS, Newburger JW. Gamma globulin re-treatment in Kawasaki disease. J Pediatr. 1993;123:657–659
  10. Chiyonobu T, Yoshihara T, Mori K, Ishida H, Nishimura Y, Yamamoto Y, et al. Early intravenous gamma globulin retreatment for refractory Kawasaki disease. Clin Pediatr (Phila). 2003;42:269–272
  11. Burns JC, Mason WH, Hauger SB, Janai H, Bastian JF, Wohrley JD, et al. Infliximab treatment for refractory Kawasaki syndrome. J Pediatr. 2005;146:662–667
  12. Egami K, Muta H, Ishii M, Suda K, Sugahara Y, Iemura M, et al. Prediction of resistance to intravenous immunoglobulin treatment in patients with Kawasaki disease. J Pediatr. 2006;149:237–240
  13. Fukunishi M, Kikkawa M, Hamana K, Onodera T, Matsuzaki K, Matsumoto Y, et al. Prediction of non-responsiveness to intravenous high-dose gamma-globulin therapy in patients with Kawasaki disease at onset. J Pediatr. 2000;137:172–176
  14. Kobayashi T, Inoue Y, Takeuchi K, Okada Y, Tamura K, Tomomasa T, et al. Prediction of intravenous immunoglobulin unresponsiveness in patients with Kawasaki disease. Circulation. 2006;113:2606–2612
  15. Newburger JW, Takahashi M, Gerber MA, Gewitz MH, Tani LY, Burns JC, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Circulation. 2004;110:2747–2771
  16. In:  Gunn L,  Nechyba C editor. The Harriet Lane Handbook. 16th edition. Philadelphia: Mosby; 2002;
  17. Durongpisitkul K, Sangtawesin C, Khongphatthanayopthin A, Panamonta M, Sopontammarak S, Sittiwangkul R, et al. Epidemiologic study of Kawasaki disease and cases resistant to IVIG therapy in Thailand. Asian Pac J Allergy Immunol. 2006;24:27–32
  18. Wallace CA, French JW, Kahn SJ, Sherry DD. Initial intravenous gammaglobulin treatment failure in Kawasaki disease. Pediatrics. 2000;105:E78

 Supported by grants from the National Heart, Lung, and Blood Institute (HL69413 and K24 HL074864), from the National Institute for Child Health and Human Development, Pediatric Pharmacology Research Unit (5U10 HD031318), and the Ciaranello Family Fund at Children's Hospital Boston.

 No reprints available.

PII: S0022-3476(07)01167-5

doi: 10.1016/j.jpeds.2007.12.021

The Journal of Pediatrics
Volume 153, Issue 1 , Pages 117-121.e3 , July 2008

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