The Journal of Pediatrics
Volume 152, Issue 6 , Pages 833-838.e1 , June 2008

Aerobic Capacity in Children with Hemophilia

  • Raoul H.H. Engelbert, PT, PCS, PhD

      Affiliations

    • Pediatric Physiotherapy and Exercise Physiology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands
    • ,
  • Martine Plantinga, MSc

      Affiliations

    • Pediatric Physiotherapy and Exercise Physiology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands
    • ,
  • Janjaap Van der Net, PT, PCS, PhD

      Affiliations

    • Pediatric Physiotherapy and Exercise Physiology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands
    • ,
  • Frank R. Van Genderen, MSc, PhD

      Affiliations

    • Pediatric Physiotherapy and Exercise Physiology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands
    • Van Creveldkliniek/Department of Haematology, University Medical Center Utrecht, Utrecht, the Netherlands.
    • ,
  • Marijke H. Van den Berg, MD, PhD

      Affiliations

    • Van Creveldkliniek/Department of Haematology, University Medical Center Utrecht, Utrecht, the Netherlands.
    • ,
  • Paul J.M. Helders, PT, PCS, MSc, PhD

      Affiliations

    • Pediatric Physiotherapy and Exercise Physiology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands
    • ,
  • Tim Takken, MSc, PhD

      Affiliations

    • Pediatric Physiotherapy and Exercise Physiology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands
    • Corresponding Author InformationReprint requests: Tim Takken, MSc, PhD, Department of Pediatric Physical Therapy and Exercise Physiology, University Hospital for Children and Youth “Wilhelmina Kinderziekenhuis,” University Medical Center Utrecht, Room KB.02.056, PO Box 85090, 3508 AB Utrecht, the Netherlands.

Received 13 July 2007 ,Revised 2 October 2007 ,Accepted 5 December 2007.

References 

  1. World Federation of Hemophilia. What is Hemophilia?. Montréal: World Federation of Hemophilia; 2004;
  2. Mulder K, Cassis F, Seuser DR, Narayan P, Dalzell R, Poulsen W. Risks and benefits of sports and fitness activities for people with haemophilia. Haemophilia. 2004;10(Suppl 4):161–163
  3. Heijnen L, Mauser-Bunschoten EP, Roosendaal G. Participation in sports by Dutch persons with haemophilia. Haemophilia. 2000;6:537–546
  4. Tiktinsky R, Falk B, Heim M, Martinovitz U. The effect of resistance training on the frequency of bleeding in haemophilia patients: a pilot study. Haemophilia. 2002;8:22–27
  5. Broderick CR, Herbert RD, Latimer J, Curtin JA, Selvadurai HC. The effect of an exercise intervention on aerobic fitness, strength and quality of life in children with haemophilia. BMC Blood Disord. 2006;6:2
  6. Falk B, Portal S, Tiktinsky R, Weinstein Y, Constantini N, Martinowitz U. Anaerobic power and muscle strength in young hemophilia patients. Med Sci Sports Exerc. 2000;32:52–57
  7. Koch B, Galioto FM, Kelleher J, Goldstein D. Physical fitness in children with hemophilia. Arch Phys Med Rehabil. 1984;65:324–326
  8. Shephard RJ, Allen C, Benade AJ, Davies CT, Di Prampero PE, Hedman R, et al. The maximum oxygen intake (An international reference standard of cardiorespiratory fitness). Bull World Health Organ. 1968;38:757–764
  9. Schoenmakers MA, Gulmans VA, Helders PJM, van den Berg HM. Motor performance and disability in Dutch children with haemophilia: a comparison with their healthy peers. Haemophilia. 2001;7:293–298
  10. Falk B, Portal S, Tiktinsky R, Zigel L, Weinstein Y, Constantini N, et al. Bone properties and muscle strength of young haemophilia patients. Haemophilia. 2005;11:380–386
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  12. Hilliard P, Funk S, Zourikian N, Bergstrom BM, Bradley CS, McLimont M, et al. Hemophilia joint health score reliability study. Haemophilia. 2006;12:518–525
  13. Beenakker EA, van der Hoeven JH, Fock JM, Maurits NM. Reference values of maximum isometric muscle force obtained in 270 children aged 4-16 years by hand-held dynamometry. Neuromuscul Disord. 2001;11:441–446
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  16. Lam C, Young N, Marwaha J, McLimont M, Feldman BM. Revised versions of the Childhood Health Assessment Questionnaire (CHAQ) are more sensitive and suffer less from a ceiling effect. Arthritis Rheum. 2004;51:881–889
  17. Aaron DJ, Kriska AM, Dearwater SR, Cauley JA, Metz KF, LaPorte RE. Reproducibility and validity of an epidemiologic questionnaire to assess past year physical activity in adolescents. Am J Epidemiol. 1995;142:191–201
  18. Bouchard C, Tremblay A, Leblanc C, Lortie G, Savard R, Theriault G. A method to assess energy expenditure in children and adults. Am J Clin Nutr. 1983;37:461–467
  19. Ainsworth BE, Haskell WL, Whitt MC, Irwin ML, Swartz AM, Strath SJ, et al. Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc. 2000;32(9 Suppl):S498–S504
  20. Van Leeuwen PB, Van der Net J, Helders PJM, Takken T. Inspanningsparameters bij gezonde Nederlandse kinderen. Geneeskunde en Sport. 2004;37:126–131
  21. Binkhorst RA, Van ’t Hof MA, Saris WHM. Maximale inspanning door kinderen; referentiewaarden voor 6-18 jarige meisjes en jongens. Den Haag: Nederlandse Hartstichting; 1992;
  22. Gerver WJM, De Bruin R. Paediatric morphometrics, a reference manual. 2nd extended ed.. Maastricht: Wetenschappelijke Uitgeverij Bunge; 2001;

 Supported by an unrestricted grant from Baxter Netherlands.

 The cohort of subjects studied is the same for both the Hemophilia Joint Health Score (HJHS) validation study and the aerobic capacity study.

PII: S0022-3476(07)01162-6

doi: 10.1016/j.jpeds.2007.12.016

The Journal of Pediatrics
Volume 152, Issue 6 , Pages 833-838.e1 , June 2008

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