« Previous
Next »
The Journal of Pediatrics
Volume 152, Issue 5
, Pages 618-621
, May 2008
Measures of β-Cell Function during the Oral Glucose Tolerance Test, Liquid Mixed-Meal Test, and Hyperglycemic Clamp Test
References
- . The importance of β-cell failure in the development and progression of type 2 diabetes. J Clin Endocrinol Metab. 2001;86:4047–4048
- . Epidemic increase in childhood overweight, 1986-1998. JAMA. 2001;286:2845–2848
- . Prevalence and trends in overweight among US children and adolescents, 1999-2000. JAMA. 2002;288:1728–1732
- . Type 2 diabetes mellitus in youth: the complete picture to date. Pediatr Clin North Am. 2005;52:1579–1609
- . Ghrelin suppression in overweight children: a manifestation of insulin resistance?. J Clin Endocrinol Metab. 2005;90:2725–2730
- . Differences in the in vivo insulin secretion and sensitivity in healthy black versus white adolescents. J Pediatr. 1996;129:440–444
- . Insulin secretion and sensitivity in black versus white prepubertal healthy children. J Clin Endocrinol Metab. 1997;82:1923–1927
- . Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 1979;237:E214–E223
- . Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents. J Pediatr. 2004;144:47–55
- . Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
- Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab. 2000;85:2402–2410
- . Development of a prediction equation for insulin sensitivity from anthropometry and fasting insulin in prepubertal and early pubertal children. Diabetes Care. 2002;25:1203–1210
- . Indexes of insulin resistance and secretion in obese children and adolescents. Diabetes Care. 2004;27:314–319
- . Indices of insulin action, disposal, and secretion derived from fasting samples and clamps in normal glucose-tolerant black and white children. Diabetes Care. 2002;25:2081–2087
- . Comparison between β-cell function and insulin resistance indexes in prepubertal and pubertal obese children. Metabolism. 2002;51:1011–1016
- Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemiologic studies. Am J Epidemiol. 2000;151:190–198
- . Understanding oral glucose tolerance: comparison of glucose or insulin measurements during the oral glucose tolerance test with specific measurements of insulin resistance and insulin secretion. Diabetes Med. 1994;11:286–292
- . Insulin release and peripheral sensitivity at the oral glucose tolerance test. Diabetes Res Clin Pract. 1990;10:167–175
- . β-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the US. Diabetes. 2002;51:2170–2178
- . Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of NIDDM in Mexican-Americans. Diabetes. 1995;44:1386–1391
- Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med. 2002;346:802–810
- The normal glucose tolerance continuum in obese youth: evidence for impairment in beta-cell function independent of insulin resistance. J Clin Endocrinol Metab. 2005;90:747–754
- Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care. 2000;23:295–301
- . Prevalence and concomitants of glucose intolerance in European obese children and adolescents. Diabetes Care. 2003;26:118–124
- Validation of insulin sensitivity indices from oral glucose tolerance test parameters in obese children and adolescents. J Clin Endocrinol Metab. 2004;89:1096–1101
- . Type 2 diabetes and impaired glucose tolerance in European children and adolescents with obesity: a problem that is no longer restricted to minority groups. Eur J Endocrinol. 2004;151:199–206
- Preservation of pancreatic (beta)-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk Hispanic women. Diabetes. 2002;51:2796–2803
- . Non-insulin dependent diabetes mellitus: a genetically programmed failure of the beta-cell to compensate for insulin resistance. N Engl J Med. 1996;334:777–783
- . Pre-diabetes in obese youth: a defect in insulin sensitivity (IS) or insulin secretion (ISC). Diabetes. 2006;55(suppl 1):A68;292-OR
- . Glucose intolerance in obese adolescents with polycystic ovary syndrome: roles of insulin resistance and beta-cell dysfunction and risk of cardiovascular disease. J Clin Endocrinol Metab. 2001;86:66–71
- . β-cell function across the spectrum of glucose tolerance in obese youth. Diabetes. 2005;54:1735–1743
- Impact of incretion hormones on β-cell function in subjects with normal or impaired glucose tolerance. Am J Physiol Endocrinol Metab. 2006;291:E1144–E1150
- Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type 1 diabetic patients. J Clin Invest. 1986;77:98–105
- Kinetics of human connecting peptide in normal and diabetic subjects. J Clin Invest. 1978;62:197–203
- . Relation of obesity to insulin secretion and clearance in adolescents: the Bogalusa Heart Study. Int J Obes Relat Metab Disord. 1996;20:951–956
- . Hyperinsulinemia in African-American children: decreased insulin clearance and increased insulin secretion and its relationship to insulin sensitivity. Diabetes. 2002;51:3014–3019
- . Insulin resistance and associated compensatory responses in African-American and Hispanic children. Diabetes Care. 2002;25:2184–2190
- . Contribution of insulin secretion and clearance to glucose-induced insulin concentration in African-American and Caucasian children. J Clin Endocrinol Metab. 2002;87:2218–2224
- . Racial (black–white) differences in insulin secretion and clearance in adolescents: the Bogalusa Heart Study. Pediatrics. 1996;97:357–360
Supported by the Children's Hospital of Pittsburgh Scientific Program (F.B.), the Pediatric Clinical and Translational Research Center at Children's Hospital of Pittsburgh (grants MO1-RR00084, UL1 RR024153, and K24HD01357) (S.A.), the Endocrine Fellows Foundation (F.B.), the Genentech Center for Clinical Research and Education (F.B.), and the Pharmacia Endocrine Care International Fund for Research and Education (F.B.)/Pfizer Endocrine Care Team.
PII: S0022-3476(07)01141-9
doi: 10.1016/j.jpeds.2007.11.044
© 2008 Mosby, Inc. All rights reserved.
« Previous
Next »
The Journal of Pediatrics
Volume 152, Issue 5
, Pages 618-621
, May 2008
