Changes in incidence of cystic fibrosis
Article Outline
In this issue of The Journal, Scotet et al studied the birth incidence of cystic fibrosis in two regions of Europe—Brittany and Northeastern Italy—over the time period 1990 to 2005. The goal was to study the impact of newborn screening for cystic fibrosis. The actual birth incidence in the two regions was similar; however, prenatal diagnosis has been utilized more commonly in Brittany. There was a higher rate of termination of pregnancy in Brittany, so there has been approximately a 30% reduction in the birth incidence. The impact of newborn screening and the effects of population mixing are discussed. The general question of how much prenatal screening can prevent birth defects is discussed in an editorial by Savitz.
page 15 (article)
page 20 (article)
page 25 (article)
page 3 (editorial)
PII: S0022-3476(07)01080-3
doi:10.1016/j.jpeds.2007.11.023
© 2008 Mosby, Inc. All rights reserved.
Refers to article:
- Prevalence, Neonatal Characteristics, and First-Year Mortality of Down Syndrome: A National Study , 19 November 2007
- Is Down Syndrome a Disappearing Birth Defect? , 22 October 2007
- Time Trends in Birth Incidence of Cystic Fibrosis in Two European Areas: Data from Newborn Screening Programs , 22 October 2007
- How Far Can Prenatal Screening Go in Preventing Birth Defects?
