The Effects of Probiotics on Feeding Tolerance, Bowel Habits, and Gastrointestinal Motility in Preterm Newborns

Indrio, Flavia; Riezzo, Giuseppe; Raimondi, Francesco; Bisceglia, Massimo; Cavallo, Luciano; Francavilla, Ruggiero

doi:10.1016/j.jpeds.2007.11.005

« Previous Next »The Journal of Pediatrics
Volume 152, Issue 6 , Pages 801-806, June 2008

The Effects of Probiotics on Feeding Tolerance, Bowel Habits, and Gastrointestinal Motility in Preterm Newborns

Flavia Indrio, MD
- Department of Pediatrics, University of Bari Policlinico, Bari, Italy
- Reprint requests: Flavia Indrio, MD, Department of Pediatrics, University of Bari, Policlinico Piazza G. Cesare, Bari, Italy.
Giuseppe Riezzo, MD
- Laboratory of Experimental Pathophysiology, Castellana Grotte, National Institute for Digestive Diseases I.R.C.C.S. “Saverio de Bellis,” Bari, Italy
Francesco Raimondi, MD
- Department of Pediatrics, University Federico II Policlinico, Naples, Italy
Massimo Bisceglia, MD
- Department of Pediatrics, Ospedale San Giovanni di Dio, Crotone, Italy.
Luciano Cavallo, Prof
- Department of Pediatrics, University of Bari Policlinico, Bari, Italy
Ruggiero Francavilla, MD, PhD
- Department of Pediatrics, University of Bari Policlinico, Bari, Italy

Received 3 July 2007; received in revised form 25 September 2007; accepted 2 November 2007. published online 03 January 2008.

Objective

To investigate the effect of dietary supplementation with a probiotic on feeding tolerance and gastrointestinal motility in healthy formula-fed preterm infants.

Study design

Thirty preterm newborns were enrolled; 10 were exclusively breast-fed, and the remaining 20 were randomly assigned in a double-blind manner to receive either Lactobacillus reuteri ATCC 55730 (at dose of 1 × 10⁸ colony forming units a day) or placebo for 30 days. Clinical symptoms of gastrointestinal function (regurgitation, vomiting, inconsolable crying, and evacuation) and physiological variables (gastric electrical activity and emptying) were recorded before and after the dietary intervention.

Results

Body weight gains per day were similar for the 3 groups, and no adverse events were recorded. Newborns receiving probiotics showed a significant decrease in regurgitation and mean daily crying time and a larger number of stools compared with those given placebo. Gastric emptying rate was significantly increased, and fasting antral area was significantly reduced in both the newborns receiving L. reuteri and breast-fed newborns compared with placebo.