The Journal of Pediatrics
Volume 152, Issue 1 , Pages 4-6 , January 2008

The Role of the Kidney in Protecting the Brain against Cerebral Edema and Neuronal Cell Swelling

  • Russell W. Chesney, MD

      Affiliations

    • Corresponding Author InformationReprint requests: Russell W. Chesney, MD, Department of Pediatrics, University of Tennessee Health Science Center, 50 North Dunlap, Memphis, TN 38103.

References 

  1. Holliday MA, Segar WE. The maintenance need for water in parenteral fluid therapy. Pediatrics. 1957;19:823–832
  2. Moritz ML, Ayus JC. Prevention of hospital-acquired hyponatremia: a case for using isotonic saline. Pediatrics. 2003;111:227–230
  3. Moritz ML, Carlos Ayus J. Hospital-acquired hyponatremia—why are hypotonic parenteral fluids still being used?. Nat Clin Pract Nephrol. 2007;3:374–382
  4. Taylor D, Durward A. Pouring salt on troubled waters. Arch Dis Child. 2004;89:411–414
  5. Verbalis JG. Whole-body volume regulation and escape from antidiuresis. Am J Med. 2006;119:S21–S29
  6. Au AK, Ray PE, McBryde KD, Newman KD, Weinstein SL, Bell MJ. Incidence hypotonical and normotonic solutions. J Pediatr. 2008;152:33–98
  7. Agre P. Nobel Lecture (Aquaporin water channels). Biosci Rep. 2004;24:127–163
  8. Knoers NV, Deen PM. Molecular and cellular defects in nephrogenic diabetes insipidus. Pediatr Nephrol. 2001;16:1146–1152
  9. Miyakawa H, Woo SK, Dahl SC, Handler JS, Kwon HM. Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity. Proc Natl Acad Sci USA. 1999;96:2538–2542
  10. Pasantes-Morales H, Lezama RA, Ramos-Mandujano G, Tuz KL. Mechanisms of cell volume regulation in hypo-osmolality. Am J Med. 2006;119:S4–S11
  11. Perlman DF, Goldstein L. Organic osmolyte channels in cell volume regulation in vertebrates. J Exp Zool. 1999;283:725–733
  12. Tsai TT, Guttapalli A, Agrawal A, Albert TJ, Shapiro IM, Risbud MV. MEK/ERK signaling controls osmoregulation of nucleus pulposus cells of the intervertebral disc by transactivation of TonEBP/OREBP. J Bone Miner Res. 2007;22:965–974
  13. Veizis IE, Cotton CU. Role of kidney chloride channels in health and disease. Pediatr Nephrol. 2007;22:770–777
  14. Verkman AS. Roles of aquaporins in kidney revealed by transgenic mice. Semin Nephrol. 2006;26:200–208
  15. Zhang Z, Ferraris JD, Brooks HL, Brisc I, Burg MB. Expression of osmotic stress-related genes in tissues of normal and hyposmotic rats. Am J Physiol Renal Physiol. 2003;285:F688–F693
  16. Papadopoulos MC, Verkman AS. Aquaporin-4 and brain edema. Pediatr Nephrol. 2007;22:778–784

PII: S0022-3476(07)00969-9

doi: 10.1016/j.jpeds.2007.10.009

The Journal of Pediatrics
Volume 152, Issue 1 , Pages 4-6 , January 2008