The Journal of Pediatrics
Volume 152, Issue 3 , Pages 305-309, March 2008

Human Papillomavirus Vaccination: Expected Impacts and Unresolved Issues

  • Amanda F. Dempsey, MD, PhD, MPH

      Affiliations

    • Corresponding Author InformationReprint requests: Amanda F. Dempsey, MD, PhD, MPH, Child Health Evaluation and Research Unit, University of Michigan, 300 North Ingalls Bldg, Rm 6E08, Ann Arbor, MI 49109-0456.
    • ,
  • Gary L. Freed, MD, MPH

Child Health Evaluation and Research Unit, University of Michigan, Ann Arbor, Michigan.

Received 26 June 2007; received in revised form 7 September 2007; accepted 28 September 2007.

In 2006, the US Food and Drug Administration licensed the first vaccine against human papillomavirus (HPV), Gardasil (Merck & Co). A second HPV vaccine, Cervarix (GlaxoSmithKline), is expected to be licensed in the near future. HPV vaccines present an exciting and unique opportunity for pediatricians to prevent cervical, and possibly other, HPV-associated cancers through vaccination. This review will focus on the quadrivalent HPV vaccine currently available in the United States, Gardasil, will describe the potential clinical and financial impacts of widespread vaccination with the vaccine, and will highlight some of the unresolved issues related to national vaccine implementation.

Abbreviations: GBS, Guillan-Barré syndrome, HPV, Human papillomavirus

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PII: S0022-3476(07)00955-9

doi:10.1016/j.jpeds.2007.09.052

The Journal of Pediatrics
Volume 152, Issue 3 , Pages 305-309, March 2008

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