The Journal of Pediatrics
Volume 152, Issue 4 , Pages 521-526.e4 , April 2008

Potential Interactions of Drug–Natural Health Products and Natural Health Products–Natural Health Products among Children

  • Ran D. Goldman, MD

      Affiliations

    • Pediatric Research in Emergency Therapeutics (PRETx) Program, Division of Pediatric Emergency Medicine, BC Children’s Hospital, Department of Pediatrics, University of British Columbia, and Child & Family Research Institute (CFRI), Vancouver, British Columbia
    • Corresponding Author InformationReprint requests: Ran D. Goldman, MD, Division of Pediatric Emergency Medicine, BC Children’s Hospital, 4480 Oak Street, Vancouver, BC, V6H 3V4, Canada.
  • ,
  • Alex L. Rogovik, MD, PhD

      Affiliations

    • Division of Pediatric Emergency Medicine, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario
  • ,
  • David Lai, BSc

      Affiliations

    • Division of Pediatric Emergency Medicine, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario
  • ,
  • Sunita Vohra, MD, MSc

      Affiliations

    • Complementary and Alternative Research and Education (CARE) Program, Department of Pediatrics, Stollery Children’s Hospital, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

Received 24 May 2007 ,Revised 18 July 2007 ,Accepted 12 September 2007.

References 

  1. Eisenberg DM, Kessler RC, Foster C, Norlock FE, Calkins DR, Delbanco TL. Unconventional medicine in the United States: prevalence, costs, and patterns of use. N Engl J Med. 1993;328:246–252
  2. Wagner PJ, Jester D, LeClair B, Taylor AT, Woodward L, Lambert J. Taking the edge off: why patients choose St. John’s Wort. J Fam Pract. 1999;48:615–619
  3. Eisenberg DM, Davis RB, Ettner SL, Appel S, Wilkey S, Van Rompay M, et al. Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey. JAMA. 1998;280:1569–1575
  4. Barnes PM, Powell-Griner E, McFann K, Nahin RL. Complementary and alternative medicine use among adults: United States, 2002. Adv Data. 2004;343:1–19
  5. Crawford NW, Cincotta DR, Lim A, Powell CV. A cross-sectional survey of complementary and alternative medicine use by children and adolescents attending the University Hospital of Wales. BMC Complement Altern Med. 2006;6:16
  6. Sommer J, Burgi M, Theiss R. Inclusion of complementary medicine increases health costs. Complement Ther Med. 1999;7:54–61
  7. van Haselen RA, Graves N, Dahiha S. The costs of treating rheumatoid arthritis patients with complementary medicine: exploring the issue. Complement Ther Med. 1999;7:217–221
  8. Breuner CC, Barry PJ, Kemper KJ. Alternative medicine use by homeless youth. Arch Pediatr Adolesc Med. 1998;152:1071–1075
  9. Kemper KJ. Complementary and alternative medicine for children: does it work?. Arch Dis Child. 2001;84:6–9
  10. Rusy LM, Weisman SJ. Complementary therapies for acute pediatric pain management. Pediatr Clin North Am. 2000;47:589–599
  11. Armishaw J, Grant CC. Use of complementary treatment by those hospitalised with acute illness. Arch Dis Child. 1999;81:133–137
  12. Hayes JA, Cox CL. The integration of complementary therapies in North and South Thames Regional Health Authorities’ critical care units. Complement Ther Nurs Midwifery. 1999;5:103–107
  13. Moenkhoff M, Baenziger O, Fischer J, Fanconi S. Parental attitude towards alternative medicine in the paediatric intensive care unit. Eur J Pediatr. 1999;158:12–17
  14. Goldman RD, Vohra S. Complementary and alternative medicine use by children visiting a pediatric emergency department. Can J Clin Pharmacol. 2004;11:e245–e256
  15. Simpson N, Pearce A, Finlay F, Lenton S. The use of complementary medicine in pediatric outpatient clinics. Ambulatory Child Health. 1998;3:351–356
  16. Wilson K, Klein J. Adolescents’ use of complementary and alternative medicine. Pediatr Res. 2000;47:13A
  17. Gulla J, Singer AJ. Use of alternative therapies among emergency department patients. Ann Emerg Med. 2000;35:226–228
  18. Weiss SJ, Takakuwa KM, Ernst AA. Use, understanding, and beliefs about complementary and alternative medicines among emergency department patients. Acad Emerg Med. 2001;8:41–47
  19. Wilson K, Busse JW, Gilchrist A, Vohra S, Boon H, Mills E. Characteristics of pediatric and adolescent patients attending a naturopathic college clinic in Canada. Pediatrics. 2005;115:e338–e343
  20. Kohn LT, Corrigan JM, Donaldson MS. To err is human: building a safer health system. Washington: National Academy Press; 2000;
  21. Kozer E, Scolnik D, Macpherson A, Keays T, Shi K, Luk T, et al. Variables associated with medication errors in pediatric emergency medicine. Pediatrics. 2002;110:737–742
  22. Hamilton RA, Briceland LL, Andritz MH. Frequency of hospitalization after exposure to known drug-drug interactions in a Medicaid population. Pharmacotherapy. 1998;18:1112–1120
  23. Galluzzi S, Zanetti O, Binetti G, Trabucchi M, Frisoni GB. Coma in a patient with Alzheimer’s disease taking low dose trazodone and gingko biloba. J Neurol Neurosurg Psychiatry. 2000;68:679–680
  24. Matthews MK. Association of Ginkgo biloba with intracerebral hemorrhage. Neurology. 1998;50:1933–1934
  25. Jones BD, Runikis AM. Interaction of ginseng with phenelzine. J Clin Psychopharmacol. 1987;7:201–202
  26. Schelosky L, Raffauf C, Jendroska K, Poewe W. Kava and dopamine antagonism. J Neurol Neurosurg Psychiatry. 1995;58:639–640
  27. Almeida JC, Grimsley EW. Coma from the health food store: interaction between kava and alprazolam. Ann Intern Med. 1996;125:940–941
  28. Lantz MS, Buchalter E, Giambanco V. St. John’s wort and antidepressant drug interactions in the elderly. J Geriatr Psychiatry Neurol. 1999;12:7–10
  29. Barbenel DM, Yusufi B, O’Shea D, Bench CJ. Mania in a patient receiving testosterone replacement postorchidectomy taking St John’s wort and sertraline. J Psychopharmacol. 2000;14:84–86
  30. Khawaja IS, Marotta RF, Lippmann S. Herbal medicines as a factor in delirium. Psychiatr Serv. 1999;50:969–970
  31. Canadian Association of Emergency Physicians. The Canadian Triage & Acuity Scale (CTAS) for Emergency Departments. http://www.caep.ca/template.asp?id=B795164082374289BBD9C1C2BF4B8D32Accessed Feb 5, 2007
  32. Drugs, Supplements, and Herbal Information (MedlinePlus, a service of the US National Library of Medicine and the National Institutes of Health). http://www.nlm.nih.gov/medlineplus/druginformation.htmlAccessed January 12, 2007
  33. Check interactions (Drug Digest). http://www.drugdigest.org/DD/Interaction/ChooseDrugsAccessed January 12, 2007
  34. Interactions by Herb or Supplement (Medical references, University of Maryland Medical Center). http://www.umm.edu/altmed/ConsLookups/InteractionsByHerbSupp.htmlAccessed January 12, 2007
  35. Fugh-Berman A. Herb-drug interactions. Lancet. 2000;355:134–138
  36. Izzo AA, Ernst E. Interactions between herbal medicines and prescribed drugs: a systematic review. Drugs. 2001;61:2163–2175
  37. Abebe W. Herbal medication: potential for adverse interactions with analgesic drugs. J Clin Pharm Ther. 2002;27:391–401
  38. Brazier NC, Levine MA. Drug-herb interaction among commonly used conventional medicines: a compendium for health care professionals. Am J Ther. 2003;10:163–169
  39. Mills E, Wu P, Johnston BC, Gallicano K, Clarke M, Guyatt G. Natural health product-drug interactions: a systematic review of clinical trials. Ther Drug Monit. 2005;27:549–557
  40. Izzo AA. Herb-drug interactions: an overview of the clinical evidence. Fundam Clin Pharmacol. 2005;19:1–16
  41. Hu Z, Yang X, Ho PC, Chan SY, Heng PW, Chan E, et al. Herb-drug interactions: a literature review. Drugs. 2005;65:1239–1282
  42. Houston JB, Levy G. Drug biotransformation interactions in man VI: acetaminophen and ascorbic acid. J Pharm Sci. 1976;65:1218–1221
  43. Buttery JE, Boord S, Ludvigsen H. Ascorbate interference in the urinary screen for acetaminophen. Clin Chem. 1988;34:769
  44. Meletis CD, Jacobs T. Interactions between drugs and natural medicines: What the physician and pharmacist must know about vitamins, minerals, foods and herbs. Sandy, OR: Eclectic Medical Publications; 1999;
  45. Chesney RW, Mazess RB, Hamstra AJ, DeLuca HF, O’Reagan S. Reduction of serum-1, 25-dihydroxyvitamin-D3 in children receiving glucocorticoids. Lancet. 1978;2:1123–1125
  46. Baggott JE, Morgan SL, Ha T, Vaughn WH, Hine RJ. Inhibition of folate-dependent enzymes by non-steroidal anti-inflammatory drugs. Biochem J. 1992;282:197–202
  47. Maskos Z, Koppenol WH. Oxyradicals and multivitamin tablets. Free Radic Biol Med. 1991;11:609–610
  48. Mallory MA, Sthapanachai C, Kowdley KV. Iron overload related to excessive vitamin C intake. Ann Intern Med. 2003;139:532–533
  49. Russell RM, Golner BB, Krasinski SD, Sadowski JA, Suter PM, Braun CL. Effect of antacid and H2 receptor antagonists on the intestinal absorption of folic acid. J Lab Clin Med. 1988;112:458–463
  50. Gal-Ezer S, Shaoul R. The safety of mineral oil in the treatment of constipation - a lesson from prolonged overdose. Clin Pediatr (Phila). 2006;45:856–858
  51. Karabiber H, Sonmezgoz E, Ozerol E, Yakinci C, Otlu B, Yologlu S. Effects of valproate and carbamazepine on serum levels of homocysteine, vitamin B12, and folic acid. Brain Dev. 2003;25:113–115
  52. Gillman MA, Sandyk R. Nicotinic acid deficiency induced by sodium valproate. S Afr Med J. 1984;65:986
  53. Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl. 1982;23:83–90
  54. Schulz HU, Schurer M, Krupp S, Dammann HG, Timm J, Gessner U. Effects of acetylsalicylic acid on ascorbic acid concentrations in plasma, gastric mucosa, gastric juice and urine–a double-blind study in healthy subjects. Int J Clin Pharmacol Ther. 2004;42:481–487
  55. Konturek PC, Kania J, Hahn EG, Konturek JW. Ascorbic acid attenuates aspirin-induced gastric damage: role of inducible nitric oxide synthase. J Physiol Pharmacol. 2006;57:125–136
  56. Ding RW, Kolbe K, Merz B, de Vries J, Weber E, Benet LZ. Pharmacokinetics of nicotinic acid-salicylic acid interaction. Clin Pharmacol Ther. 1989;46:642–647
  57. Bays HE, Dujovne CA. Drug interactions of lipid-altering drugs. Drug Saf. 1998;19:355–371
  58. Liede KE, Haukka JK, Saxen LM, Heinonen OP. Increased tendency towards gingival bleeding caused by joint effect of alpha-tocopherol supplementation and acetylsalicylic acid. Ann Med. 1998;30:542–546
  59. Marcuard SP, Albernaz L, Khazanie PG. Omeprazole therapy causes malabsorption of cyanocobalamin (vitamin B12). Ann Intern Med. 1994;120:211–215
  60. Seifried HE, McDonald SS, Anderson DE, Greenwald P, Milner JA. The antioxidant conundrum in cancer. Cancer Res. 2003;63:4295–4298
  61. Ulusakarya A, Vantelon JM, Munck JN, Fenaux P, Rerat K. Thiamine deficiency in a patient receiving chemotherapy for acute myeloblastic leukemia. Am J Hematol. 1999;61:155–156
  62. Gonzalez JP, Valdivieso A, Calvo R, Rodríguez-Sasiaín JM, Jimenez R, Aguirre C, et al. Influence of vitamin C on the absorption and first pass metabolism of propranolol. Eur J Clin Pharmacol. 1995;48:295–297
  63. Russell RM, Dutta SK, Oaks EV, Rosenberg IH, Giovetti AC. Impairment of folic acid absorption by oral pancreatic extracts. Dig Dis Sci. 1980;25:369–373
  64. Goldsmith LA, Bolognia JL, Callen JP, Chen SC, Feldman SR, Lim HW, et al. American Academy of Dermatology American Academy of Dermatology Consensus Conference on the safe and optimal use of isotretinoin: summary and recommendations. J Am Acad Dermatol. 2004;50:900–906
  65. Toskes PP, Deren JJ. Selective inhibition of vitamin B12 absorption by para-aminosalicylic acid. Gastroenterology. 1972;62:1232–1237
  66. Andres E, Noel E, Goichot B. Metformin-associated vitamin B12 deficiency. Arch Intern Med. 2002;162:2251–2252
  67. Alston TA. Does metformin interfere with thiamine?. Arch Intern Med. 2003;163:983
  68. Domingo JL, Gomez M, Llobet JM, Richart C. Effect of ascorbic acid on gastrointestinal aluminium absorption. Lancet. 1991;338:1467
  69. Gordon JB. SSRIs and St. John’s wort: possible toxicity?. Am Fam Physician. 1998;57:950;953
  70. Falguera M, Perez-Mur J, Puig T, Cao G. Study of the role of vitamin B12 and folinic acid supplementation in preventing hematologic toxicity of zidovudine. Eur J Haematol. 1995;55:97–102
  71. Rosenthal G. Interaction of ascorbic acid and warfarin. JAMA. 1971;215:1671
  72. Corrigan JJ. The effect of vitamin E on warfarin-induced vitamin K deficiency. Ann N Y Acad Sci. 1982;393:361–368
  73. Vinson JA, Al Kharrat H, Andreoli L. Effect of aloe vera preparations on the human bioavailability of vitamins C and E. Phytomedicine. 2005;12:760–765
  74. Matthews MK. Association of Ginkgo biloba with intracerebral hemorrhage. Neurology. 1998;50:1933–1934
  75. Cupp MJ. Herbal remedies: adverse effects and drug interactions. Am Fam Physician. 1999;59:1239–1245
  76. Hodges PJ, Kam PC. The peri-operative implications of herbal medicines. Anaesthesia. 2002;57:889–899
  77. Silverstein DD, Spiegel AD. Are physicians aware of the risks of alternative medicine?. J Community Health. 2001;26:159–174

 Sponsored by the Hospital for Sick Children Foundation’s Research Grants in Complementary and Alternative Therapies and Child and Youth Health Competition and supported by the Child & Family Research Institute (CFRI), BC Children’s Hospital.

PII: S0022-3476(07)00886-4

doi: 10.1016/j.jpeds.2007.09.026

The Journal of Pediatrics
Volume 152, Issue 4 , Pages 521-526.e4 , April 2008