Defining the Metabolic Syndrome in Children and Adolescents: Will the Real Definition Please Stand Up?
Objectives
To review the use of definitions of the metabolic syndrome in studies of children and adolescents and to review results from studies that used factor analysis to examine structure among cardiometabolic variables.
Study design
Literature review.
Results
In 27 publications, authors used 40 unique definitions of the metabolic syndrome. Most of these definitions were adaptations of the adult definition developed by the National Cholesterol Education Program. In 11 studies that used exploratory factor analysis, the number of components ranged from 5 to 19, and the number of factors identified ranged from 1 to 5.
Conclusions
The use of multiple definitions of the metabolic syndrome argues strongly for the development of a standard pediatric definition.
Abbreviations: EGIR, European Group for the Study of Insulin Resistance, HOMA, Homeostasis model assessment, NCEP, National Cholesterol Education Program, WHO, World Health Organization
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The findings and conclusions in this article are those of the authors and do not represent the views of the Centers for Disease Control and Prevention.
PII: S0022-3476(07)00754-8
doi:10.1016/j.jpeds.2007.07.056
© 2008 Mosby, Inc. All rights reserved.
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