Childhood Obesity Predicts Adult Metabolic Syndrome: The Fels Longitudinal Study

Sun, Shumei S.; Liang, Ruohong; Huang, Terry T.-K.; Daniels, Stephen R.; Arslanian, Silva; Liu, Kiang; Grave, Gilman D.; Siervogel, Roger M.

doi:10.1016/j.jpeds.2007.07.055

« Previous Next »The Journal of Pediatrics
Volume 152, Issue 2 , Pages 191-200.e1, February 2008

Childhood Obesity Predicts Adult Metabolic Syndrome: The Fels Longitudinal Study

Shumei S. Sun, PhD
- From the Lifespan Health Research Center, Department of Community Health, Wright State University Boonshoft School of Medicine, Dayton, OH
- Reprint requests: Shumei S. Sun, PhD, Department of Community Health, 3171 Research Blvd, Dayton, OH 45420.
Ruohong Liang, MS
- From the Lifespan Health Research Center, Department of Community Health, Wright State University Boonshoft School of Medicine, Dayton, OH
Terry T.-K. Huang, PhD, MPH
- Endocrinology, Nutrition and Growth Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD
Stephen R. Daniels, MD, PhD
- Department of Pediatrics, University of Colorado School of Medicine, Denver, CO
Silva Arslanian, MD
- Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA
Kiang Liu, PhD
- Department of Preventive Medicine, Northwestern University Medical School, Chicago, IL.
Gilman D. Grave, MD
- Endocrinology, Nutrition and Growth Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD
Roger M. Siervogel, PhD
- From the Lifespan Health Research Center, Department of Community Health, Wright State University Boonshoft School of Medicine, Dayton, OH

Received 5 February 2007; received in revised form 12 June 2007; accepted 31 July 2007. published online 01 November 2007.

Objectives

To determine the age of significant divergence in body mass index (BMI) and waist circumference in adults with and without the metabolic syndrome, and to provide age- and sex-specific childhood values that predict adult metabolic syndrome.

Study design

Part 1 of this study is a retrospective cohort study of 92 men and 59 women (mean age, 51 years) who had metabolic syndrome and 154 randomly selected adults matched for age and sex who did not have the syndrome. Part 2 is a study of predictive accuracy in a validation sample of 743 participants.

Results

The first appearance of differences between adults with and without metabolic syndrome occurred at ages 8 and 13 for BMI and 6 and 13 for waist circumference in boys and girls, respectively. Odds ratios (ORs) for the metabolic syndrome at 30 years and older ranged from 1.4 to 1.9 across age groups in boys and from 0.8 to 2.8 across age groups in girls if BMI exceeded criterion values in childhood. The corresponding ORs for waist circumference ranged from 2.5 to 31.4 in boys and 1.7 to 2.5 in girls. These ORs increased with the number of examinations.

Conclusions

Children with BMI and waist circumference values exceeding the established criterion values are at increased risk for the adult metabolic syndrome.

Abbreviations: ATP, Adult Treatment Panel, BMI, Body mass index, CDC, Centers for Disease Control and Prevention, EBMI, Elevated body mass index, EWC, Elevated waist circumference, HDL, High-density lipoprotein, NCEP, National Cholesterol Education Program, NHANES, National Health and Nutrition Examination Survey, OR, Odds ratio, ROC, Receiver operating characteristics

To access this article, please choose from the options below

Supported by in part by National Institutes of Health grants DK 071485, HL 072838, and HD 12252.This manuscript was prepared for the Pediatric Metabolic Syndrome Working Group.

PII: S0022-3476(07)00752-4

doi:10.1016/j.jpeds.2007.07.055

Refers to article:

Finding Thresholds of Risk for Components of the Pediatric Metabolic Syndrome
Terry T.-K. Huang
The Journal of Pediatrics February 2008 (Vol. 152, Issue 2, Pages 158-159.e1)
- Full Text
- PDF (58 KB)
Defining the Metabolic Syndrome in Children and Adolescents: Will the Real Definition Please Stand Up? , 01 November 2007
Earl S. Ford, Chaoyang Li
The Journal of Pediatrics February 2008 (Vol. 152, Issue 2, Pages 160-164.e13)
Metabolic Syndrome Rates in United States Adolescents, from the National Health and Nutrition Examination Survey, 1999–2002 , 18 October 2007
Stephen Cook, Peggy Auinger, Chaoyang Li, Earl S. Ford
The Journal of Pediatrics February 2008 (Vol. 152, Issue 2, Pages 165-170.e2)
Examining Metabolic Syndrome Definitions in Overweight Hispanic Youth: A Focus on Insulin Resistance , 22 October 2007
Gabriel Q. Shaibi, Michael I. Goran
The Journal of Pediatrics February 2008 (Vol. 152, Issue 2, Pages 171-176)
Comparison of Different Definitions of Pediatric Metabolic Syndrome: Relation to Abdominal Adiposity, Insulin Resistance, Adiponectin, and Inflammatory Biomarkers , 22 October 2007
SoJung Lee, Fida Bacha, Neslihan Gungor, Silva Arslanian
The Journal of Pediatrics February 2008 (Vol. 152, Issue 2, Pages 177-184.e3)
Sensitivity, Specificity, and Predictive Values of Pediatric Metabolic Syndrome Components in Relation to Adult Metabolic Syndrome: The Princeton LRC Follow-up Study , 18 October 2007
Terry T.-K. Huang, Tonja R. Nansel, Allen R. Belsheim, John A. Morrison
The Journal of Pediatrics February 2008 (Vol. 152, Issue 2, Pages 185-190.e5)
Metabolic Syndrome in Childhood Predicts Adult Metabolic Syndrome and Type 2 Diabetes Mellitus 25 to 30 Years Later , 05 November 2007
John A. Morrison, Lisa Aronson Friedman, Ping Wang, Charles J. Glueck
The Journal of Pediatrics February 2008 (Vol. 152, Issue 2, Pages 201-206)
Waist-to-Height Ratio, a Useful Index to Identify High Metabolic Risk in Overweight Children , 19 November 2007
Claudio Maffeis, Claudia Banzato, Giorgio Talamini, Obesity Study Group of the Italian Society of Pediatric Endocrinology and Diabetology
The Journal of Pediatrics February 2008 (Vol. 152, Issue 2, Pages 207-213.e2)